Abstracts tagged "PPAR and Pulmonary hypertension"

Abstract Number: 1052 • 2019 ACR/ARP Annual Meeting
The PPAR Agonist Lanifibranor Protects Against Right Ventricular Hypertrophy in a Mouse Model of Systemic Sclerosis Associated Pulmonary Hypertension
Emma Derrett-Smith ¹, Kristina Clark¹, Shiwen Xu ¹, David Abraham ¹, Olivier Lacombe ², Pierre Broqua ², Jean-Louis Junien ², Irena Konstantinova ² and Christopher Denton ³, ¹University College London, London, United Kingdom, ²Inventiva, Daix, France, ³University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom
Background/Purpose: The TβRIIΔk-fib transgenic mouse model of systemic sclerosis (SSc) develops constitutive structural vasculopathy with vessel wall fibrosis and is susceptible to pulmonary hypertension (PH)…

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Abstracts tagged "PPAR and Pulmonary hypertension"

The PPAR Agonist Lanifibranor Protects Against Right Ventricular Hypertrophy in a Mouse Model of Systemic Sclerosis Associated Pulmonary Hypertension