Abstracts tagged "positron emission tomography (PET) and rheumatoid arthritis (RA)"

Abstract Number: 244 • 2017 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Imaging on PET-CT Using a Novel Folate Receptor Ligand for Macrophage Targeting
Nicki Verweij¹, Stefan Bruijnen¹, Yoony Gent², Marc Huisman³, Gerrit Jansen², Carla Molthoff⁴, Qingshou Chen⁵, Philip Low⁵, Albert Windhorst³, Adriaan Lammertsma³, Otto Hoekstra³, Alexandre Voskuyl² and Conny van der Laken², ¹Dept. of Rheumatology, Amsterdam Rheumatology and immunology Center - location VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, ²Department of Rheumatology, Amsterdam Rheumatology and immunology Center - location VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, ³Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, ⁴Department of Radiology & Nuclear Medicine, Amsterdam Rheumatology and immunology Center - location VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, ⁵Department of Chemistry, Purdue University, West Lafayette, IN, USA, West Lafayette, IN
Background/Purpose: PET imaging with macrophage tracers has been shown promising for detection of (sub)clinical synovitis, making it useful for both early diagnostics and therapy monitoring…
Abstract Number: 1470 • 2016 ACR/ARHP Annual Meeting
Moderate to Severe Disease Activity in Rheumatoid Arthritis Is Associated with Myocardial 18f-Fluorodeoxyglucose (18F-FDG) Uptake
Isabelle Amigues¹, Jon T. Giles², Afshin Zartoshti³, Rachelle Morgenstern⁴, Raul Flores⁵, Sabahat Bokhari⁶ and Joan Bathon⁷, ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Rheumatology, Columbia University Medical Center, NY, NY, ³Rheumatology, Columbia University, College of Physicians & Surgeons, New York city, NY, ⁴Cardiology, columbia university college of physicians and surgeons, New York city, NY, ⁵Medicine, Columbia University, New York Presbyterian, New York city, NY, ⁶Cardiology, Columbia University College of Physicians & Surgeons, NY, NY, ⁷Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY
Background/Purpose: RA patients are at increased risk for developing heart failure (HF) even after controlling for coronary artery disease (CAD), indicating that factors other than…
Abstract Number: 1471 • 2016 ACR/ARHP Annual Meeting
Myocardial 18f-Fluorodeoxyglucose (18F-FDG) Uptake in RA Patients without Clinical Cardiovascular Disease Is Higher Than in Controls and Decreases with Treatment
Isabelle Amigues¹, Jon T. Giles², Afshin Zartoshti³, Rachelle Morgenstern⁴, Raul Flores⁵, Sabahat Bokhari⁶ and Joan Bathon⁷, ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Rheumatology, Columbia University Medical Center, NY, NY, ³Rheumatology, Columbia University, College of Physicians & Surgeons, New York city, NY, ⁴Cardiology, columbia university college of physicians and surgeons, New York city, NY, ⁵Medicine, Columbia University, New York Presbyterian, New York city, NY, ⁶Cardiology, Columbia University College of Physicians & Surgeons, NY, NY, ⁷Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY
Background/Purpose: Symptomatic heart failure (HF) and HF-associated mortality rates are higher in RA compared with the non-RA population, even after controlling for coronary artery…
Abstract Number: 1182 • 2014 ACR/ARHP Annual Meeting
Do Patients with Active RA Also Have Inflamed Atherosclerotic Plaques on PET-MRI?
Sarah Skeoch¹, Heather Williams², Penny Cristanacce³, Jacqueline James⁴, Paul Hockings⁵, Yvonne Alexander⁶, John Waterton^7,8 and Ian N. Bruce⁹, ¹University of Manchester, Manchester, United Kingdom, ²Centre for Imaging Sciences Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom, ³Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom, ⁴Department of Nuclear Medicine, Central Manchester University Hospitals Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁵MedTech West, Chalmers University of Technology, Gottenburg, Sweden, ⁶Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁷R&D Personalised Healthcare & Biomarkers, Astra Zeneca, MACCLESFIELD, United Kingdom, ⁸Bioimaging Institute, University of Manchester, Manchester, United Kingdom, ⁹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Inflammation plays a key role in the progression and destabilisation of atherosclerotic plaque in the general population. In RA, inflammation is thought to accelerate…
Abstract Number: 1941 • 2013 ACR/ARHP Annual Meeting
Imaging Atherosclerotic Plaque Inflammation In RA: Methodology and Initial Findings In a Single Centre Cohort
Sarah Skeoch¹, Penny Hubbard², Heather Williams^3,4, Dongxiang Xu⁵, Sun Jie⁵, Niranjan Balu⁵, Wei Zhang⁵, Jacqueline James³, Thomas Hatsukami⁵, Chun Yuan⁵, M. Yvonne Alexander⁶, Paul Hockings⁷, John Waterton^4,8 and Ian N. Bruce⁹, ¹Arthritis Research UK Centre for Epidemiology and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ²Centre for Imaging Sciences Biomedical Imaging Institute Oxford Road Manchester, M13 9PT United Kingdom, University of Manchester, Manchester, United Kingdom, ³Department of Nuclear Medicine, Central Manchester University Hospitals Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁴Centre for Imaging Sciences Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom, ⁵Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA, ⁶Healthcare Science Research Institute, Faculty of Science and Engineering, Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁷Drug Safety and Metabolism, Astra Zeneca, Mölndal, Sweden, ⁸R&D Personalised Healthcare & Biomarkers, Astra Zeneca, MACCLESFIELD, United Kingdom, ⁹Kellgren Centre for Rheumatology, Central Manchester University Hospitals Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: Chronic inflammation in RA may contribute to an unstable atherosclerotic plaque phenotype. Dynamic contrast enhanced MRI (DCE MRI) can be used to image carotid…
Abstract Number: 381 • 2013 ACR/ARHP Annual Meeting
Coronary Endothelial Dysfunction Directly Measured By N13 Positron Emission Tomography (PET) Is Detected In Established Rheumatoid Arthritis (RA), But Not Early RA
OM Troum¹, OL Pimienta¹, B Hidalgo² and WA Hsueh³, ¹Keck School of Medicine, University of Southern California, Los Angeles, CA, ²Biostatistics, University of Alabama, Birmingham, AL, ³Medicine, Weill Cornell Medical College, Houston, TX
Background/Purpose: Rheumatoid arthritis (RA) is associated with increased risk of cardiovascular (CV) disease. The endothelium is a key regulator of vascular function. Subclinical CV disease and…
Abstract Number: 1040 • 2012 ACR/ARHP Annual Meeting
Combined High-Resolution Single Photon Emission Computed Tomography and Magnetic Resonance Imaging for Therapy Monitoring in Rheumatoid Arthritis
Philipp Sewerin¹, Christian Buchbender², Katalin Mattes-György³, Falk Miese², Hans-Jörg Wittsack², Christof Specker⁴, Gerald Antoch², Matthias Schneider⁵, Axel Scherer² and Ben Ostendorf¹, ¹Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany, ²Diagnostic and Interventional Radiology, Heinrich-Heine-University, Düsseldorf, Germany, ³Nuclear Medicine, Heinrich-Heine-University, Düsseldorf, Germany, ⁴Department of rheumatology and clinical immunology, Hospital Essen Sued, Essem, Germany, ⁵Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany
Background/Purpose: To evaluate whether combined multi-pinhole single photon emission computed tomography (MPH-SPECT) with technetium-99m-labelled disphosphonates (Tc99m-DPD) and magnetic resonance imaging (MRI) detect changes in inflammation…

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