Abstracts tagged "population studies"

Abstract Number: 2659 • ACR Convergence 2025
Sodium-Glucose Cotransporter 2 Inhibitors for the Primary Prevention of Systemic Autoimmune Rheumatic Diseases in Patients with Type 2 Diabetes: A Population-Based Target Trial Emulation
Jamie Chieh Lo¹, Karen H. Costenbader² and Kevin Sheng-Kai Ma³, ¹National Taiwan University Hospital, Keelung, Taipei, Taiwan (Republic of China), ²Harvard Medical School and Brigham and Women's Hospital, Boston, MA, ³Center for Global Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States, Philadelphia, PA
Background/Purpose: Treatment with dipeptidyl peptidase-4 inhibitors (DPP4i) have been shown to reduce the risk of systemic autoimmune rheumatic diseases (SARD) in patients with type 2…
Abstract Number: 1031 • ACR Convergence 2025
Trends and Gender Disparities in Rheumatoid Arthritis Burden in the United States: A Population-Based Time-Trend Analysis Using the Global Burden of Disease Database, 1990–2021
Satani Sharkas¹, Dina Murad² and Dariush Jahandideh³, ¹Boston Medical Center - Brighton, Brighton, MA, ²Tufts Medical Center, Boston, MA, ³Boston Medical Center - Brighton, Boston
Background/Purpose: Rheumatoid arthritis (RA) is a growing public health concern in the United States, with increasing prevalence and disease burden over recent decades. This study…
Abstract Number: 2590 • ACR Convergence 2025
Translating findings on urate-metabolizing bacterial genes and urate levels at the human population level: a gut microbiome analysis of three independent cohorts of men and women
Sharan Rai¹, Natalie McCormick², Xochitl Morgan³, Matthew Nayor⁴, Robert Terkeltaub⁵, Dylan Dodd⁶, Lama Nazzal⁷, Huilin Li⁷, Gary Curhan⁸, Curtis Huttenhower³ and Hyon K. Choi⁹, ¹Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Harvard T.H. Chan School of Public Health, Boston, ⁴Boston University, Boston, ⁵Retired, San Diego, CA, ⁶Stanford University, Palo Alto, CA, ⁷NYU Langone, New York, NY, ⁸Brigham and Women's Hospital, Boston, ⁹MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA
Background/Purpose: Approximately 21% of US adults have hyperuricemia, the causal precursor for gout. Human cells do not degrade urate (due to uricase gene inactivation). However,…
Abstract Number: 1018 • ACR Convergence 2025
Factors Associated with Mortality in Systemic Lupus Erythematosus under a Universal Healthcare System: Results from the CAPTURED Study, a Population-Based Cohort in Catalonia, Spain
José Gomez-Puerta¹, Cristian Tebe², Maria Grau³, Beatriz Frade Sosa⁴, Juan Camilo Sarmiento-Monroy⁵, Cristina Carbonell-Abella⁶, Daniel Martinez-Laguna⁷, Patricia Corzo⁸, Raimon Sanmartí⁹ and J. Antonio Aviña-Zubieta¹⁰, ¹Rheumatology Department, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, ²Instituto de Investigación Germans Trias i Pujol, Badalona, Spain, ³University of Barcelona, Barcelona, Spain, ⁴Hospital Clinic de Barcelona, Barcelona, Catalonia, Spain, ⁵Hospital Clínic Barcelona, Barcelona, Spain, ⁶Medicina Familiar y Comunitaria, Centro de Salud Vía Roma, Barcelona, Spain, ⁷Grup de recerca en malalties prevalents de l'Aparell locomotor en Atenció Primaria (GREMPAL), ICS, Barcelona, Spain, ⁸Rheumatology Department, Hospital Clínic, Barcelona, Barcelona, Spain, ⁹Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain, ¹⁰University of British Columbia/Arthritis Research Canada, Vancouver, BC, Canada
Background/Purpose: The differences in lupus-related mortality reported in population studies are partly explained by racial disparities and access to healthcare. However, population-based data from universal…
Abstract Number: 2571 • ACR Convergence 2025
Rare Clinically Significant Methotrexate Toxicity Despite Frequent Laboratory Abnormalities: A Population-Based Study of Methotrexate Monitoring
Griffin Reed¹, Jeffrey Yang¹, Georges El Hasbani¹, Cynthia Crowson², Hannah Langenfeld¹, Jeffrey Sparks³, Bryant England⁴, gabriela Schmajuk⁵, Kaleb Michaud⁴, John Davis¹ and Vanessa Kronzer¹, ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Stewartvillle, MN, ³Brigham and Women's Hospital, Boston, MA, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, CA
Background/Purpose: Methotrexate laboratory monitoring is highly resource intensive, and recent evidence questions whether the true toxicity of methotrexate has been over-estimated. Therefore, we aimed to…
Abstract Number: 0675 • ACR Convergence 2025
Neutrophil-to-Lymphocyte Ratio as a biomarker for disease onset and a predictor for mortality in Systemic Sclerosis – real-world data from a large healthcare provider in Israel.
Shiri Keret¹, Shlomit Yaari², gleb Slobodin³ and doron Rimar³, ¹Bnai Zion Medical Center, Atlit, Israel, ²Maccabi Healthcare Services, HaMered ²⁷, Tel Aviv, ⁶⁸¹²⁵, Israel., Tel Aviv, Israel, ³Bnai Zion Medical Center Faculty of Medicine, Technion Israel institute of technology, Haifa, Israel
Background/Purpose: Elevated neutrophil-to-lymphocyte ratio (NLR) in systemic sclerosis (SSc) has been demonstrated to predict worsening skin and lung involvement, and a cutoff of 2.95 was…
Abstract Number: 2400 • ACR Convergence 2025
Prevalence and Predictors of Types and Subtypes of Pulmonary Diseases in Systemic Lupus Erythematosus: A Population-Based Cross-Sectional Study Using High-Resolution Computed Tomography Scan and Pulmonary Function Testing
Henrik Zachar Langkilde¹, Jesper Davidsen², Stefan Harders³, Stefan Luef⁴, Susan Kay⁵, Tine Lottenburger⁶, Stavros Chrysidis⁷, Karen Schreiber⁸, Elisabet Svenungsson⁹, Sille Fløjborg¹⁰, Robin Christensen¹¹ and Anne Voss¹², ¹Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Denmark, Odense, Denmark, ²South Danish Center for Interstitial Lung Diseases (SCILS) and Pulmo-Rheuma Frontline Center (PURE), Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark, Odense, Syddanmark, Denmark, ³Research Unit of Department of Radiology, University of Southern Denmark, Odense University Hospital, Denmark., Odense, Syddanmark, Denmark, ⁴Odense Respiratory Research Unit (ODIN), Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark, Odense, Syddanmark, Denmark, ⁵Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Denmark, Odense, Syddanmark, Denmark, ⁶Department of Rheumatology, Vejle Hospital, Vejle, Denmark, Vejle, Syddanmark, Denmark, ⁷Department of Rheumatology, Esbjerg Hospital, University Hospital of Southern Denmark, Esbjerg, Denmark, Esbjerg, Syddanmark, Denmark, ⁸Danish Center for Expertise in Rheumatology (CeViG), Danish Hospital for Rheumatic Diseases, Sønderborg, Denmark, Soenderborg, Syddanmark, Denmark, ⁹Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, ¹⁰Systemic Lupus Erythematosus Patient Research Partner, Department of Rheumatology, Odense University Hospital, Denmark, Odense, Syddanmark, Denmark, ¹¹Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen, Hovedstaden, Denmark, ¹²Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Denmark, Odense C, Syddanmark, Denmark
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disease that potentially affects any organ. Pulmonary diseases (PD) are common in SLE and cover several different…
Abstract Number: 0603 • ACR Convergence 2025
Transverse Myelitis in Systemic Lupus Erythematosus: Disease Manifestations and Clinical Outcomes from Multi-Center Data
Amir Daneshvar¹, Areeb Tiwana², Dana Nachawati¹, Keri Ann Pfeil¹, Elleson Harper¹, Lindsay Frumker³, Meghan Gump¹ and Omer Pamuk⁴, ¹University Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, OH, ²Canton Medical Education Foundation, Canton, OH, ³University hospitals Cleveland medical center, Highland Heights, OH, ⁴University Hospitals Cleveland Medical Center/ Case Western Reserve University, Cleveland, OH
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with widespread clinical manifestations. Neuropsychiatric SLE (NPSLE), a complex and poorly understood subset of SLE,…
Abstract Number: 2305 • ACR Convergence 2025
Predictors of Hospitalization and Emergency Department Visits Among Patients with Psoriatic Disease: Insights from the Forward Psoriasis Registry
Alexis Ogdie¹, Ellen Romich², Brian Coburn³, Rebecca Schumacher⁴ and Kaleb Michaud⁵, ¹Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Wilmington, DE, ²University of Pennsylvania, Media, PA, ³Hospital of the University of Pennsylvania, Philadelphia, PA, ⁴FORWARD, The National Databank for Rheumatic Diseases, Wichita, KS, ⁵University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Patients with psoriasis and psoriatic arthritis (PsA) are at increased risk for metabolic comorbidities and poorer long-term outcomes compared to the general population. Identifying…
Abstract Number: 0745 • ACR Convergence 2025
Prevalence and Clinical Significance of Low ESR and CRP in Giant Cell Arteritis: A Population Based Study
Eugenio de Miguel, Natalia López-Juanes, Maria-Eugenia Miranda-Carus, Carlota Ureta, Chamaida Plasencia-Rodríguez and Irene Monjo Henry, Hospital Universitario La Paz, Madrid, Spain
Background/Purpose: Traditionally, elevated erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) had been considered a hallmark of GCA and both are included in the 2022…
Abstract Number: 2093 • ACR Convergence 2025
Association of Acetaminophen Use with Clinical Outcomes in Older Adults with Osteoarthritis: A Global Propensity-Matched Retrospective Cohort Analysis
Justin Riley Lam¹, Laith Alomari², Emmanuel Otabor², Michael Hamilton², Bal Subedi³, Maxim Barnett², Fabian Rodriguez Quinonez⁴ and Irene Tan⁵, ¹Albert Einstein Medical Center, Philadelphia, PA, ²Jefferson Einstein Hospital Philadelphia, Philadelphia, PA, ³Jefferson Einstein Montogmery Hospital, Philadelphia, ⁴Einstein Medical Center Philadelphia, Philadelphia, PA, ⁵Einstein Healthcare Network Philadelphia - Jefferson Health, Bala Cynwyd, PA
Background/Purpose: Acetaminophen is widely recommended for osteoarthritis (OA) pain management due to its perceived safety profile. However, its long-term effects on clinical outcomes among older…
Abstract Number: 0399 • ACR Convergence 2025
External Validation of Claims-based Algorithms for Newly Diagnosed Juvenile Idiopathic Arthritis
Daniel Horton¹, Lauren Parlett², Yuyang Zhu³, Sanika Rege⁴, Patricia Hoffman⁵, Daniel Reiff⁶, Sarah McGuire⁷, Sonia Pothraj⁸, Cynthia Salvant⁹, Lakshmi Moorthy¹, Cecilia Huang⁴, Dawn Koffman⁴, Matthew Iozzio³, Alicia Iizuka⁴, Kevin Schott², Stephen Crystal¹⁰, Amy Davidow¹¹, Tobias Gerhard⁴, Kevin Haynes¹², Brian Strom¹³, Daniel Beachler² and Carlos Rose¹⁴, ¹Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ²Carelon Research, Inc, Wilmington, DE, ³Rutgers Center for Pharmacoepidemiology and Treatment Science, Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, NJ, USA, New Brunswick, ⁴Rutgers Center for Pharmacoepidemiology and Treatment Science, Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, NJ, USA, New Brunswick, NJ, ⁵Hospital for Special Surgery, New York, NY, ⁶Boys Town National Research Hospital, Boys Town, ⁷Department of Obstetrics and Gynecology, Cooper Medical School, Camden, Camden, NJ, ⁸Washingtonville Pediatrics, Washingtonville, NY, ⁹Albany Medical Center, Albany, NY, ¹⁰Rutgers Center for Health Services Research, Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, ¹¹New Jersey Medical School, Newark, NJ, ¹²Janssen Research & Development, Titusville, NJ, ¹³Rutgers Biomedical and Health Sciences, New Brunswick, ¹⁴Thomas Jefferson University, Wilmington, DE
Background/Purpose: Administrative claims databases enable research in large populations with JIA. We previously showed that machine learning (ML)-based algorithms accurately identify new JIA diagnoses within…
Abstract Number: 1873 • ACR Convergence 2024
Race/Ethnicity and Household Income at the County Level Interacts with the Association of Urbanicity and Lupus Nephritis Mortality
Snehin Rajkumar¹, Eric Yen² and Ram Singh³, ¹UCLA David Geffen School of Medicine, Irvine, CA, ²UCLA, Los Angeles, CA, ³UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: The reasons underlying substantial variation in lupus nephritis (LN) deaths by race/ethnicity remain largely unknown. There are no large population-based studies focused on the…
Abstract Number: 1879 • ACR Convergence 2024
Prevalence of Relapsing Polychondritis in Colombia: Data from the National Health Registry 2018 – 2023
Mario Bautista-Vargas¹, Adrian Romero-Ocampo², Juan José Pino Vélez³, juliana Muñoz-Bedoya⁴ and Diego Rosselli⁵, ¹Mayo Clinic, Rochester, Minnesota, USA., Rochester, MN, ²Universidad de Antioquia, Medellín – Colombia, Medellin, Antioquia, Colombia, ³Universidad de Antioquia, Envigado, Antioquia, Colombia, ⁴Universidad Corpas, Bogotá, Colombia, ⁵Pontificia Universidad Javeriana, Bogotá, Colombia
Background/Purpose: The implementation of the SISPRO system enables it to function as a tool capable of collecting pertinent health system data. This information is publicly…
Abstract Number: 1882 • ACR Convergence 2024
30-Day Readmission Among Patients with Rheumatoid Arthritis and Their Independent Predictors: Insights from National Readmission Database
Shobhit Piplani¹, Priyanshu Jain², Vladimir Jelic³, Clement Tagoe⁴ and Beverly Johnson⁵, ¹Jacobi Medical Center/North Central Bronx Albert Einstein College of Medicine NYC Health and Hospitals, Bronx, NY, ²Jawaharlal Nehru Medical College, Belgaum, Karnataka, India, Bronx, NY, ³Jacobi Medical Center/North Central Bronx, Bronx, NY, ⁴Albert Einstein College of Medicine, FRESH MEADOWS, NY, ⁵Albert Einstein College of Medicine, New York, NY
Background/Purpose: Rheumatoid Arthirits (RA) is associated with heightened morbidity, diminished quality of life, and increased healthcare expenses. This research aims to bridge this gap by…

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