Abstracts tagged "polymorphism and systemic sclerosis"

Abstract Number: 2997 • 2015 ACR/ARHP Annual Meeting
A Genome-Wide Association Study of a Hispanic Systemic Sclerosis Cohort
Lara Bossini-Castillo¹, Enrique Raya², John D. Reveille³, Shervin Assassi⁴, Olga Y Gorlova⁵, Dinesh Khanna⁶, Daniel E. Furst⁷, Suzanne Kafaja⁸, Robert W. Simms⁹, Robert Lafyatis⁹, Tracy M. Frech¹⁰, Virginia D. Steen¹¹, Barri J. Fessler¹², Jerry A. Molitor¹³, Marta Alarcón-Riquelme^14,15, Javier Martín¹⁶ and Maureen D Mayes⁴, ¹Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS Granada, Granada, Spain, ²Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, ³Internal Medicine/Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁴Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁵Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁶Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁷Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁸Rheumatology, University of California Los Angeles, Los Angeles, CA, ⁹Rheumatology, Boston University School of Medicine, Boston, MA, ¹⁰Div of Rheumatology, University of Utah, Salt Lake City, UT, ¹¹Department of Rheumatology, Georgetown University Medical Center, Washington, DC, ¹²Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ¹³Rheumatology, University of Minnesota, Minneapolis, MN, ¹⁴Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma, OK, ¹⁵Centre for Genomics and Oncological Research (GENYO), Pfizer–University of Granada–Junta de Andalucia, Parque Tecnológico de la Salud (PTS), Granada, Spain, ¹⁶Instituto de Parasitología y Biomedicina López- Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain
Background/Purpose: Genome-wide association studies (GWASs) have resulted in the identification of several genetic loci involved in systemic sclerosis (SSc) susceptibility. However, GWASs are normally focused…
Abstract Number: 1130 • 2014 ACR/ARHP Annual Meeting
IRF8 Gene Contributes to Disease Susceptibility and Interacts with NF-KB By Modulating Interferon Signature in Patients with Systemic Sclerosis
Maria Arismendi^1,2, Matthieu Giraud¹, Nadira Ruzehaji¹, Philippe Dieude³, Eugénie Koumakis⁴, Barbara Ruiz⁵, Paolo Airo⁶, Daniele Cusi⁷, Marco Matucci-Cerinic⁸, Erika Salvi⁹, Giovanna Cuomo¹⁰, Eric Hachulla¹¹, Elizabeth Diot¹², Paola Caramaschi¹³, Valeria Riccieri¹⁴, Jerome Avouac¹⁵, Cristiane Kayser¹⁶ and Yannick Allanore¹⁷, ¹INSERM U1016, Paris Descartes University, Paris, France, ²Department of Rheumatology, Federal University of São Paulo, São Paulo, Brazil, ³Rhumatologie, Hopital Bichat Claude Bernard, Paris, France, ⁴Rheumatology A department, Cochin Hospital, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁵Paris Descartes University, INSERM U1016, Institut Cochin, Sorbonne Paris Cité, Paris, France, ⁶Rheumatology and Clinical Immunology, Spedali Civili, AO Spedali Civili, Brescia, Italy, ⁷Department of Medicine, Surgery and Dentistry San Paolo & Genomics and Bioinformatics Platform, Fondazione Filarete, University of Milano, Milano, Italy, ⁸RAID working group for EULAR, Zurich, Switzerland, ⁹Department of Medicine, Surgery and Dentistry San Paolo & Genomics and Bioinformatics Platform, Fondazione Filarete, University of Milano, Milan, Italy, ¹⁰Department of Internal and Experimental Medicine, Second University of Naples, Naples, Italy, ¹¹Faculté de Médecine Henri Warembourg, Université Lille Nord de France, Lille, France, ¹²Department of Internal Medicine, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, Tours, France, Tours, France, ¹³Rheumatology Unit, Department of Medicine, Verona, Italy, ¹⁴Department of Internal Medicine and Medical Specialities, University Sapienza, Rome, Italy, ¹⁵Cochin Hospital, Paris, France, ¹⁶Rheumatology Division, Universidade Federal de São Paulo, São Paulo - SP, Brazil, ¹⁷Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France
Background/Purpose . Systemic Sclerosis (SSc) is a polygenic autoimmune disease (AID) characterized by fibroblast dysregulation. It shares some genetic bases with other AIDs, as evidenced…
Abstract Number: 745 • 2014 ACR/ARHP Annual Meeting
Genetic Susceptibility Loci of Idiopathic Interstitial Pneumonitis Do Not Represent Risk for Systemic Sclerosis
Minghua Wu¹, Shervin Assassi¹, Gloria Salazar¹, Olga Y Gorlova², Wei V Chen³, Julio Charles⁴, Fredrick M. Wigley⁵, Laura K. Hummers⁵, Ami A. Shah⁵, Monique Hinchcliff⁶, Dinesh Khanna⁷, Elena Schiopu⁸, Kristine Phillips⁷, Daniel E. Furst⁹, Virginia D. Steen¹⁰, Murray Baron¹¹, Marie Hudson¹¹, Xiaodong Zhou¹, Janet E. Pope¹², Niall Jones¹³, Peter Docherty¹⁴, Nader A. Khalidi¹⁵, David B. Robinson¹⁶, Robert W. Simms¹⁷, Richard Silver¹⁸, Tracy Frech¹⁹, Barri J. Fessler²⁰, Marvin J. Fritzler²¹, Jerry A. Molitor²², Barbara M. Segal²², Javier Martín²³, John Varga²⁴ and Maureen D Mayes¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁵Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁸Rheumatology, University of Michigan, Ann Arbor, MI, ⁹University of California, Los Angeles, Department of Medicine, Los Angeles, CA, ¹⁰Department of Rheumatology, Georgetown University Medical Center, Washington, DC, ¹¹Division of Rheumatology, McGill University, Montreal, QC, Canada, ¹²Medicine/Rheumatology, St. Joseph's Health Care, University of Western Ontario, London, ON, Canada, ¹³Division of Rheumatology, University of Alberta, Edmonton, AB, Canada, ¹⁴Internal Medicine, The Moncton Hospital, Moncton, NB, Canada, ¹⁵Division of Rheumatology, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, ¹⁶Arthritis Centre, University of Manitoba, Winnipeg, MB, Canada, ¹⁷Rheumatology, Boston University School of Medicine, Boston, MA, ¹⁸Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ¹⁹Div of Rheumatology, University of Utah, Salt Lake City, UT, ²⁰Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²¹Mitogen Advanced Diagnostics Laboratory, Faculty of Medicine, University of Calgary, Calgary, AB, Canada, ²²Rheumatology, University of Minnesota, Minneapolis, MN, ²³Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain, ²⁴Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Systemic sclerosis (SSc) related interstitial lung disease (ILD) has phenotypic similarities to idiopathic interstitial pneumonia (IIP). The objective of this study was to assess…
Abstract Number: 86 • 2014 ACR/ARHP Annual Meeting
Association of Leukocyte Immunoglobulin-like Receptor A3 (LILRA3) with Systemic Sclerosis
Yuki Hachiya¹, Aya Kawasaki¹, Takashi Matsushita², Hiroshi Furukawa³, Shouhei Nagaoka⁴, Kota Shimada⁵, Shoji Sugii⁵, Takayuki Sumida⁶, Shigeto Tohma³, Minoru Hasegawa⁷, Manabu Fujimoto⁸, Shinichi Sato⁹, Kazuhiko Takehara¹⁰ and Naoyuki Tsuchiya¹, ¹Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Deramtology, Kanazawa University, Kanazawa, Japan, ³Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ⁴Department of Rheumatology, Yokohama Minami Kyousai Hospital, Yokohama, Japan, ⁵Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, ⁶Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁷Dermatology, University of Fukui, Yoshida-gun, Fukui, Japan, ⁸Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁹Department of Dermatology, The University of Tokyo, Tokyo, Japan, ¹⁰Dermatology, Kanazawa University, Kanazawa, Japan
Background/Purpose: The leukocyte immunoglobulin-like receptors (LILRs) are a gene family located in leukocyte receptor complex at 19q13.4. LILRs are expressed mainly in immune cells as…
Abstract Number: 701 • 2012 ACR/ARHP Annual Meeting
Vascular Differences Associated to Genetic Polymorphisms of Endothelial Nitric Oxide Synthase in Mexican Patients with Systemic Sclerosis. A Preliminary Report
Maria Pilar Cruz-Dominguez¹, Maria Angeles Martinez-Godinez², Angel Miliar-Garcia², Daniel Hector Montes-Cortes³, Olga Vera-Lastra⁴, Luis J. Jara-Quezada⁵ and Anabel Reyes-Salazar⁶, ¹Division of Research, Hospital de Especialidades Centro Medico Nacional La Raza., Mexico, DF, Mexico, ²Postgraduate Studies and Research Section, Escuela Superior de Medicina. IPN,, Mexico, D.F., Mexico, ³Investigación, Hospital General CMN La Raza, IMSS, Mexico DF, Mexico, ⁴Internal Medicine, MD, Mexico City, Mexico, ⁵Direction of Education and Research, Hospital de Especialidades Centro Médico La Raza, IMSS, Mexico City, Mexico, ⁶Angiology, Hospital de especialidades Centro Medico National “La Raza”, IMSS, Mexico, D.F., Mexico
Background/Purpose: Vascular dysfunction usually is observed before clinically detectable fibrosis of systemic sclerosis (SSc). The eNOS catalyses the synthesis of nitric oxide (NO), which maintains…

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