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Abstracts tagged "polyarteritis nodosa and vasculitis"

  • Abstract Number: 1702 • 2019 ACR/ARP Annual Meeting

    Target Organ Associations in Polyarteritis Nodosa (PAN): Results of a Worldwide Collaboration Study

    Omer Karadag1, Shunsuke Furuta 2, Alojzija Hocevar 3, Ummugulsum Gazel 4, Andrea Hinojosa-Azaola 5, Serdal Ugurlu 6, Seerapani Gopaluni 7, Ertugrul Cagri Bolek 8, Berkan Armagan 9, Fatma Alibaz-Oner 10, Matija Tomšič 11, Gizem Ayan 12, Ayten Yazici 13, Eduardo Martin-Nares 14, Susy Marcela Sánchez-Cubías 5, Mehmet Nedim Tas 15, Ayşe Cefle 16, Kenan Aksu 17, Hajime Kono 18, Tamihiro Kawakami 19, Yoshiyuki Abe 20, Timuçin Kaşifoğlu 21, Mehmet Engin Tezcan 22, Onay Gercik 23, Sadettin Kilickap 24, Haner Direskeneli 25, Seza Ozen 26, Ali İhsan Ertenli 8 and David Jayne 7, 1Hacettepe University Vasculitis Centre, Ankara, Turkey / Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, UK, Ankara, Turkey, 2Department of Alergy and Immunology, Chiba University Hospital, Chiba, Japan, Chiba, Japan, 3Department of Rheumatology, University Medical Center Ljubljana, Slovenia, LJUBLJANA, Slovenia, 4Marmara University, Faculty of Medicine, Department of Rheumatology, Istanbul, Turkey, Istanbul, Turkey, 5Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Mexico City, Mexico, 6Istanbul University - Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, istanbul, Turkey, 7Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, UK, Cambridge, United Kingdom, 8Hacettepe University Vasculitis Centre, Ankara, Turkey, ankara, Turkey, 9Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey., Ankara, Turkey, 10Marmara University Faculty of Medicine,Department of Rheumatology,Istanbul,Turkey, Istanbul, Turkey, 11Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, LJUBLJANA, Slovenia, 12University of Ottawa Faculty of Medicine, Rheumatology, Ottawa, ON, Canada, 13Kocaeli University, Faculty of Medicine, Division of Rheumatology, Kocaeli, Kocaeli, Turkey, 14Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 15Ege University, Faculty of Medicine, Department of Rheumatology, Izmir, Turkey, Izmir, Turkey, 16Division of Rheumatology, Kocaeli University School of Medicine, Kocaeli, Turkey, Kocaeli, Turkey, 17Ege University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, 18Teikyo University School of Medicine, Tokyo, Japan, 19Department of Dermatology, Tohoku Medical and Pharmaceutical University, Japan, Tohoku, Japan, 20Department of Rheumatology, Juntendo University, Tokyo, Japan, Tokyo, Japan, 21Eskişehir Osmangazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Eskişehir, Turkey, 22Department of Rheumatology, Kartal Dr. Lutfi Kirdar Training and Research Hospital , Istanbul, Turkey, Istanbul, Turkey, 23Izmir Katip Celebi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, 24Hacettepe University, Faculty of Medicine, Department of Preventive Oncology, Ankara, Turkey, Ankara, Turkey, 25Marmara University, School of Medicine, Division of Rheumatology, Istanbul, Turkey, 26Hacettepe University Hospital, Ankara, Turkey

    Background/Purpose: Polyarteritis nodosa (PAN) is a rare type of the systemic vasculitides with heterogeneous presentations.There is a paucity of information on the current phenotypes, ethnic and…
  • Abstract Number: 1767 • 2018 ACR/ARHP Annual Meeting

    Occurrence and Etiology of Gastrointestinal Perforation in Patients with Vasculitis

    Vanessa L. Kronzer1, Daniel Larson2, Cynthia S. Crowson3,4, Kenneth J. Warrington5, Steven R. Ytterberg5, Ashima Makol4 and Matthew J. Koster4, 1Internal Medicine, Mayo Clinic, Rochester, MN, 2Pathology, Mayo Clinic, Rochester, MN, 3Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, 4Rheumatology, Mayo Clinic, Rochester, MN, 5Rheumatology, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN

    Background/Purpose: This study aimed to characterize the presenting features and outcomes of patients with small- or medium-vessel vasculitis and gastrointestinal perforation. Methods: Using a retrospective…
  • Abstract Number: 1884 • 2018 ACR/ARHP Annual Meeting

    Clinical Features and Outcome of Patients with Polyarteritis Nodosa – a Global Collaborative Study

    Omer Karadag1,2, Shunsuke Furuta3, Alojzija Hočevar4, Ummugulsum Gazel5, Seerapani Gopaluni6, Berkan Armagan1, Matija Tomsic7, Fatma Alibaz-Oner8, Ihsan Ertenli1, Seza Ozen1 and David Jayne2, 1Hacettepe University Vasculitis Center (HUVAC), Ankara, Turkey, 2Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, Cambridge, United Kingdom, 3Chiba University Hospital, Chiba, Japan, 4Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 5Rheumatology, Marmara University faculty of Medicine, Istanbul, Turkey, 6Medicine, University of Cambridge, Cambridge, United Kingdom, 7Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 8Department of Rheumatology, Marmara University, Faculty of Medicine, Istanbul, Turkey

    Background/Purpose: Polyarteritis nodosa (PAN) is a rare subgroup of the primary systemic vasculitides. Furthermore, various subgroups of PAN have been described, such as hepatitis B…
  • Abstract Number: 2790 • 2018 ACR/ARHP Annual Meeting

    Screening of Patients with Adult-Onset Idiopathic Polyarteritis Nodosa for Deficiency of Adenosine Deaminase 2

    Oskar Schnappauf1, Monique Stoffels2, Ivona Aksentijevich2, Daniel L. Kastner2, Peter C. Grayson3, David Cuthbertson4, Simon Carette5, Sharon A. Chung6, Lindsy J. Forbess7, Nader A. Khalidi8, Curry L. Koening9, Carol Langford10, Carol A. McAlear11, Paul A. Monach12, Larry W. Moreland13, Christian Pagnoux14, Philip Seo15, Jason Springer16, Antoine G. Sreih17, Kenneth J. Warrington18, Steven R. Ytterberg18 and Peter A. Merkel19, 1NHGRI, National Institutes of Health, Bethesda, MD, 2Metabolic, Cardiovascular, and Inflammatory Disease Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 3National Institute of Arthritis, Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD, 4Biostatistics and Informatics, Department of Pediatrics, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, 5Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 6Russell/Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, 7Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 8Rheumatology, McMaster University, Hamilton, ON, Canada, 9Rheumatology, Division of Rheumatology, University of Utah, Salt Lake City, UT, 10Rheumatic and Immunologic Diseases, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 11Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 12Section of Rheumatology, Boston University School of Medicine, Boston, MA, 13Division of Rheumatology and Clinical Immunology, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, 14Division of Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 15Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, MD, 16Department of Internal Medicine, The University of Kansas Medical Center, Division of Allergy, Clinical Immunology & Rheumatology, Kansas City, KS, 17Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 18Rheumatology, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN, 19Division of Rheumatology and the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Deficiency of adenosine deaminase 2 (DADA2) is the first described type of monogenic vasculitis. Patients usually present in childhood, but age of onset, disease…
  • Abstract Number: 824 • 2018 ACR/ARHP Annual Meeting

    Comparing Childhood- Versus Adult-Onset Polyarteritis Nodosa

    Michele Iudici1, Pierre Quartier2, Christian Pagnoux3, Etienne Merlin4, Christian Agard5, Achille Aouba6, Pascal Roblot7, Pascal Cohen1, Benjamin Terrier1, Luc Mouthon1, Loïc Guillevin1 and Xavier Puéchal1, 1National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 2AP-HP, Institut des Maladies Génétiques (IMAGINE), and Université Paris-Descartes, Necker-Enfants Malades Hospital, Paris, France, 3Division of Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 4CHU, Clermont-Ferrand, France, 5Nantes Hôtel Dieu, Nantes, France, 6Caen, Caen, France, 7CHU, Poitiers, France

    Background/Purpose: To investigate differences between childhood (cPAN)- and adult-onset polyarteritis nodosa (aPAN) patients. Methods: cPAN patients’ clinical findings at onset and outcomes were compared to…
  • Abstract Number: 2749 • 2017 ACR/ARHP Annual Meeting

    Four-Distinct Phenotypes of Patients with Necrotizing Arteritis of Medium and Small Arteries

    Tsuyoshi Shirai1, Hiroshi Fujii1, Yoko Fujita2, Yuko Shirota1, Tomonori Ishii1 and Hideo Harigae1, 1Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan, 2Department of Hematolgy and Rheumatolgy, Tohoku University Graduate School of Medicine, Sendai, Japan

    Background/Purpose: Polyarteritis nodosa (PAN) is a necrotizing arteritis of medium and small arteries. PAN is divided into systemic and cutaneous PAN (cPAN). cPAN can be…
  • Abstract Number: 864 • 2015 ACR/ARHP Annual Meeting

    Anticytokine Autoantibody Profiling in Five Types of Systemic Vasculitis

    Sarthak Gupta1,2, Seema K. Patel2, Mary Blake2, Massimo G. Gadina2, Wanxia L. Tsai2, Simon Carette3, David Cuthbertson4, Gary S. Hoffman5, Nader A. Khalidi6, Curry L. Koening7, Carol A. Langford5, Carol A. McAlear8, Larry W. Moreland9, Paul A. Monach10, Christian Pagnoux3, Philip Seo11, Ulrich Specks12, Antoine G. Sreih13, Steven R. Ytterberg14, Sarah K. Browne1,15, Steven M. Holland1, Mariana J. Kaplan2, Peter A. Merkel16, Peter C. Grayson2 and Vasculitis Clinical Research Consortium, 1Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 2National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 4Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, 5Rheumatology, Cleveland Clinic, Cleveland, OH, 6Division of Rheumatology, St. Joseph’s Health Care, McMaster University, Hamilton, ON, Canada, 7Division of Rheumatology, University of Utah, Salt Lake City, UT, 8Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 9Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 10Rheumatology, Boston University School of Medicine, Boston, MA, 11Division of Rheumatology, Johns Hopkins University, Baltimore, MD, 12Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN, 13Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, 14Rheumatology Division, Mayo Clinic, Rochester, MN, 15Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 16Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Anticytokine autoantibodies (ACAs) are pathogenic in many hematologic, pulmonary and infectious diseases. Evaluation in autoimmune diseases, including systemic lupus erythematosus (SLE), shows that ACAs…
  • Abstract Number: 3033 • 2015 ACR/ARHP Annual Meeting

    Polyarteritis Nodosa and Cutaneous Arteritis: Are They Distinct Diseases?

    Fatma Alibaz-Oner1, Matthew J. Koster2, Cynthia S. Crowson3, Ashima Makol2, Steven R. Ytterberg2, Eric L. Matteson2 and Kenneth J. Warrington2, 1Department Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 2Rheumatology, Mayo Clinic, Rochester, MN, 3Health Sciences Research, Mayo Clinic, Rochester, MN

    Background/Purpose: Polyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis predominantly targeting medium-sized visceral arteries.  Cutaneous arteritis (CA) is generally limited to the medium-sized vessels…
  • Abstract Number: 1782 • 2014 ACR/ARHP Annual Meeting

    Long-Term Follow-up of Non-HBV Polyarteritis Nodosa and Microscopic Polyangiitis with Poor-Prognosis Factors

    Maxime Samson1, Xavier Puéchal2, Hervé Devilliers3, Pascal Cohen2, Boris Bienvenu4, Kim Heang Ly5, Alain Bruet6, Brigitte Gilson7, Marc Ruivard8, Edouard Pertuiset9, Mohamed Hamidou10, Benjamin Terrier2, Christian Pagnoux11, Luc Mouthon2, Loic Guillevin12 and The French Vasculitis Study Group (FVSG)12, 1Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France; Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, 2National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, 3Dijon University Hospital, Department of internal medicine and systemic diseases, Dijon, France, 4Médecine interne, CHU Côte de Nacre, CAEN, France, 5CHU Dupuytren, Limoges, Limoges, France, 6Department of Nephrology and Internal Medicine, CH de Poissy Saint-Germain-en-Laye, Poissy, France, 7Department of Nephrology and Internal Medicine, CH de Verdun, Verdun, France, 8CHU Estaing, Clermont–Ferrand, Clermont–Ferrand, France, 9Rheumatology, René Dubos Hospital, Pontoise, France, 10CHU Hôtel Dieu, Nantes, Nantes, France, 11Division of Rheumatology, University of Toronto, Toronto, ON, Canada, 12Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France

    Background/Purpose To study the long-term outcomes of 65 patients with non-HBV polyarteritis nodosa (PAN) or microscopic polyangiitis (MPA) enrolled in a prospective, randomized, open-label trial,1…
  • Abstract Number: 808 • 2014 ACR/ARHP Annual Meeting

    Biomarkers of Disease Activity in Vasculitis  

    Alicia Rodriguez-Pla1, Roscoe L. Warner2, David Cuthbertson3, Simon Carette4, Gary S. Hoffman5, Nader A. Khalidi6, Curry L Koening7, Carol A. Langford8, Kathleen Maksimowicz-McKinnon9, Larry W. Moreland10, Christian Pagnoux4, Philip Seo11, Ulrich Specks12,13, Kenneth J. Warrington14, Steven R. Ytterberg15, Peter A. Merkel16, Kent J. Johnson2, Paul A. Monach17 and For the Vasculitis Research Consortium18, 1Rheumatology, Boston University, Boston, MA, 2Pathology, University of Michigan, Ann Arbor, MI, 3Department of Biostatistics, University of South Florida, Tampa, FL, 4Division of Rheumatology, University of Toronto, Toronto, ON, Canada, 5Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, 6Internal Medicine/Rheumatology, McMaster University, Hamilton, ON, Canada, 7Division of rheumatology, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City and University of Utah, University of Utah School of Medicine, Salt Lake City, UT, 8Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, 9Rheumatology, Henry Ford Hospital, Detroit, MI, 10Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 11Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, 12Frederichs Dr NW, Mayo Clinic, Rochester, MN, 13Mayo Clinic, Rochester, MN, 14Division of Rheumatology, Mayo Clinic, Rochester, MN, 15Rheumatology Division, Mayo Clinic, Rochester, MN, 16University of Pennsylvania, Philadelphia, PA, 17Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA, 18U Pennsylvania, Philadelphia, PA

    Background/Purpose To identify circulating proteins that distinguish between active vasculitis and remission in giant cell arteritis (GCA), Takayasu's  arteritis (TAK), polyarteritis nodosa (PAN) and eosinophilic…
  • Abstract Number: 2642 • 2013 ACR/ARHP Annual Meeting

    A Novel Genetic Basis For Systemic Vasculitis: Polyarteritis Nodosa Caused By Recessive Mutations In An Immune-Related Gene

    Reeval Segel1,2, Pnina Elkan-Navon3, Sarah B. Pierce4, Tom Walsh4, Judith Barash5, Shay Padeh6, Avraham Zlotogorski7, Yackov Berkun8, Isabel Voth9, Philip Hashkes10, Liora Harel11, Eduard Ling12, Fatos Yalcinkaya13, Ozgur Kasapcopur14, Paul F. Renbaum15, Ariella Weinberg-Shukron15, Barbara Schormair16, Mordechai Shohat17, Alan A. Rubinow18, Elon Pras19, Juliane Winkelmann20, Mustafa Tekin21, Yair Anikster22, Mary-Claire King4 and Ephrat Levy-Lahad15, 1Medical Genetics and Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel, 2Hebrew University Medical School, Jerusalem, Israel, 3Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel, 4Medical Genetics, University of Washington, Seattle, WA, 5Pediatric Day Care, Kaplan Medical Center, Rehovot, Israel, 6Pediatrics, Sheba Medical Center, Ramat Gan, Israel, 7Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, 8Pediatrics, Hadassah Medical Center, Mount Scopus, Jerusalem, Israel, 9Department of Neurology, Technische Universitat Munchen Klinikum rechts der Isar, Munich, Germany, 10Pediatric Rheumatology, Shaare Zedek Medical Center, Jerusalem, Israel, 11Pediatric Rheumatology unit, Schneider Children's Medical Center, Tel Aviv University, Petach Tikvah, Israel, 12Rheumatology Unit, Soroka University Medical Center and Ben-Gurion University, Beer-Sheva, Beer Sheva, Israel, 13Pediatric Nephrology and Rheumatology, Ankara University, Ankara, Turkey, 14Ankara University, Ankara, Turkey, 15Medical Genetics, Shaare Zedek Medical Center, Jerusalem, Israel, 16Helmholtz Zentrum Munchen, Munich, Germany, 17Rafael Recanati medical genetics Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikvah, Israel, 18Hadassah Medical Center, Jerusalem, Israel, 19Institute of Human Genetics, Sheba Medical Center, Ramat Gan, Israel, 20Genetics, Stanford University, San Francisco, CA, 21Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, 22Metabolic Disease Unit, Sheba Medical Center, Ramat Gan, Israel

    Background/Purpose: Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis. Disease pathogenesis and possible genetic factors are poorly understood.  We identified familial, mostly pediatric PAN, in…
  • Abstract Number: 1545 • 2012 ACR/ARHP Annual Meeting

    Long-Term Follow-up of 118 Polyarteritis Nodosa and Microscopic Polyangiitis without Poor-Prognosis Factors

    Maxime Samson1, Xavier Puechal2, Hervé Devilliers3, Camillo Ribi4, Pascal Cohen5, Boris Bienvenu6, Christian Pagnoux7, Luc Mouthon8, Loic Guillevin9 and French Vasculitis Study Group FVSG10, 1Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France; Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, 2Internal Medicine, Hôpital Cochin, Paris, France, 3Internal medicine, Hôpital Général, Dijon, France, 4Internal Medicine, Hôpital Universitaire Cantonal de Genève, Geneve, Switzerland, 5National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, 6Division of Internal Medicine, Centre Hospitalier Régional Universitaire de Caen, Côte de Nacre, Caen, France, Caen, France, 7Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada, 8Internal Medicine, Hopital Cochim, Paris, France, 9Internal Medicine, Division of Internal Medicine, Hôpital Cochin, University Paris Descartes, Paris, France, 10Internal Medicine, Service de médecine interne, Centre de Références des Vascularites, Université Paris Descartes, APHP, Hôpital Cochin, 75005 Paris, France., Paris, France

    Background/Purpose: Polyarteritis nodosa (PAN) and microscopic polyangiitis (MPA) are 2 vasculitides characterized by necrotizing inflammation of the vessel wall. They share several clinical features and…
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