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Abstracts tagged "platelets and systemic lupus erythematosus (SLE)"

  • Abstract Number: 2934 • 2015 ACR/ARHP Annual Meeting

    Endothelial Dysfunction in SLE-the Role of Platelets and Type I Interferon

    Helena Tydén1, Christian Lood2, Birgitta Gullstrand3, Andreas Jönsen4 and Anders A. Bengtsson5, 1Department of Clinical Sciences, Division of Rheumatology Lund University and Skane University Hospital Lund Sweden, Lund University, Lund, Sweden, 2Department of Clinical Sciences, Division of Rheumatology, Lund University and Skane University Hospital Lund Sweden, Lund University, Lund, Sweden, 3Department of Clinical Sciences, Division of Rheumatology Lund University and Skane University Hospital, Lund University, Lund, Sweden, 4Department of Rheumatology, Lund University Hospital, Lund, Sweden, 5Rheumatology, Inst of Clinical sciences, Lund, Sweden

    Background/Purpose: Type I interferon (IFN) may affect endothelial progenitor cells leading to endothelial dysfunction in SLE. SLE patients have a type I IFN signature in…
  • Abstract Number: 2180 • 2015 ACR/ARHP Annual Meeting

    Primary Antiphospholipid Syndrome Patients Display Increased Levels of Cell-Bound C4d in Comparison to SLE and Healthy Donors

    Maria Gerosa1,2, Paola Adele Lonati3, Tania Ubiali1, Martina Cornalba1, Maria Orietta Borghi1,4 and Pier Luigi Meroni1,2,5, 1Department of Clinical Sciences and Community Health, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy, 2Division of Rheumatology, Division of Rheumatology, Istituto Ortopedico Gaetano Pini, Milan, Italy, 3Laboratory of Immuno-rheumatology, Laboratory of Immuno-rheumatology, IRCCS Istituto Auxologico Italiano, Cusano Milanino, Jamaica, 4Laboratory of Immuno-rheumatology, IRCCS Istituto Auxologico Italiano, Milan, Italy, 5Laboratory of Immuno-rheumatology, Laboratory of Immuno-rheumatology, IRCCS Istituto Auxologico Italiano, Cusano Milanino, Italy

    Background/Purpose: Systemic Lupus Erythematosus (SLE) patients display high levels of the cell-bound complement activation factor C4d deposits on erythrocytes, B lymphocytes and platelets. In particular,…
  • Abstract Number: 587 • 2013 ACR/ARHP Annual Meeting

    Low-Dose Aspirin Has An Anti-Platelet Effect In Systemic Lupus Erythematosus

    Michelle Petri1, Laurence S. Magder2 and Thomas Kickler1, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD

    Background/Purpose: Thrombosis is increased in SLE patients, with and without antiphospholipid antibodies.  Aspirin and hydroxychloroquine are thought to have anti-platelet effects.  We determined whether these…
  • Abstract Number: 20 • 2013 ACR/ARHP Annual Meeting

    Complement Deposition On Platelets Is Associated To Venous Thrombosis In Systemic Lupus Erythematosus

    Christian Lood1, Helena Tydén1, Birgitta Gullstrand2, Gunnar Sturfelt3, Andreas Jönsen1, Lennart Truedsson2 and Anders A. Bengtsson1, 1Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, 2Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden, 3Department of Clinical Sciences Lund, Section of Rheumatology, Lund University, Lund, Sweden

    Background/Purpose: Anti-phospholipid (aPL) antibodies are associated with development of venous thrombosis and stroke in the autoimmune disease systemic lupus erythematosus (SLE). The underlying mechanism for…
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