Abstracts tagged "Plasticity"

Abstract Number: 961 • 2015 ACR/ARHP Annual Meeting
Altered Th Cell Plasticity Favors Th17 Cells in Rheumatoid Arthritis
Jan Leipe¹, Fausto Pirronello², Hendrik Schulze-Koops² and Alla Skapenko², ¹Division of Rheumatology, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: Previously, T helper (Th) cell subsets have been regarded as irreversibly differentiated endpoints. However, evidence suggests that Th cell differentiation is a plastic process…
Abstract Number: 2821 • 2015 ACR/ARHP Annual Meeting
Increased CD4 T Cell GM-CSF Production in Spondyloarthritis
M Hussein Al-Mossawi¹, Jelle De Wit², Anna Ridley³ and Paul Bowness¹, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ³Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom
Background/Purpose: Immunological, genetic and therapeutic studies have implicated the IL-17A/IL-23 inflammatory axis in SpA. GM-CSF is emerging as a cytokine that marks out a pathogenic…
Abstract Number: 3029 • 2015 ACR/ARHP Annual Meeting
Increased Plasticity of Non-Classic Th1 Cells Towards the Th17 Phenotype
Antonia Klose¹, Fausto Pirronello¹, Hendrik Schulze-Koops¹, Jan Leipe² and Alla Skapenko¹, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Division of Rheumatology, University of Munich, Munich, Germany
Background/Purpose: Mechanisms underlying the predominance of Th17 cells observed in RA are not fully understood. Th cell plasticity is a potential mechanism leading to enrichment…
Abstract Number: 2845 • 2014 ACR/ARHP Annual Meeting
Altered Plasticity of Inflammatory CD4 T Cells Contributing to Th17 Shift in Rheumatoid Arthritis
Jan Leipe, Fausto Pirronello, Simon Hermann, Matthias Witt, Hendrik Schulze-Koops and Alla Skapenko, Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose Whereas T helper (Th) cell subsets were previously regarded as irreversibly differentiated endpoints, evidence suggests that Th cell differentiation is a plastic process in…
Abstract Number: 1132 • 2014 ACR/ARHP Annual Meeting
A Novel Epigenetic Mark, Histone H1 Fucosylation, Orchestrates Macrophage Differentiation and Plasticity By Remodeling the Enhancer Landscape in Rheumatoid Arthritis
Jun Li¹, Keith Giles², Parastoo Azadi³, Mayumi Ishihara³, PingAr Yang¹, Qi Wu¹, Bao Luo¹, David M. Spalding⁴, James A Mobley⁵, S. Louis Bridges Jr.^6,7, Hui-Chen Hsu¹ and John D. Mountz^1,8, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Stem cell Institute, Birmingham, AL, ³University of Georgia, Complex Carbohydrate Research Center, Athens, GA, ⁴University of Alabama at Birmingham, Division of Clinical Immunology & Rheumatology, Birmingham, AL, ⁵University of Alabama at Birmingham, Comprehensive Cancer Center Mass Spectrometry/Proteomics Facility, Birmingham, AL, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁸Birmingham VA Medical Center, Birmingham, AL
Background/Purpose There is an imbalance of inflammatory M1 vs. anti-inflammatory M2 macrophages (MΦs) in rheumatoid arthritis (RA). The epigenetic codes underlying this M1 dominating pathogenesis…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].