Abstract Number: 961 • ACR/ARHP Annual Meeting 2015
Altered Th Cell Plasticity Favors Th17 Cells in Rheumatoid Arthritis
Background/Purpose: Previously, T helper (Th) cell subsets have been regarded as irreversibly differentiated endpoints. However, evidence suggests that Th cell differentiation is a plastic process…Abstract Number: 2821 • ACR/ARHP Annual Meeting 2015
Increased CD4 T Cell GM-CSF Production in Spondyloarthritis
Background/Purpose: Immunological, genetic and therapeutic studies have implicated the IL-17A/IL-23 inflammatory axis in SpA. GM-CSF is emerging as a cytokine that marks out a pathogenic…Abstract Number: 3029 • ACR/ARHP Annual Meeting 2015
Increased Plasticity of Non-Classic Th1 Cells Towards the Th17 Phenotype
Background/Purpose: Mechanisms underlying the predominance of Th17 cells observed in RA are not fully understood. Th cell plasticity is a potential mechanism leading to enrichment…Abstract Number: 2845 • ACR/ARHP Annual Meeting 2014
Altered Plasticity of Inflammatory CD4 T Cells Contributing to Th17 Shift in Rheumatoid Arthritis
Background/Purpose Whereas T helper (Th) cell subsets were previously regarded as irreversibly differentiated endpoints, evidence suggests that Th cell differentiation is a plastic process in…Abstract Number: 1132 • ACR/ARHP Annual Meeting 2014
A Novel Epigenetic Mark, Histone H1 Fucosylation, Orchestrates Macrophage Differentiation and Plasticity By Remodeling the Enhancer Landscape in Rheumatoid Arthritis
Background/Purpose There is an imbalance of inflammatory M1 vs. anti-inflammatory M2 macrophages (MΦs) in rheumatoid arthritis (RA). The epigenetic codes underlying this M1 dominating pathogenesis…
ACR Meeting Abstracts