Abstracts tagged "Plasmablasts and antibodies"

Abstract Number: 1081 • 2016 ACR/ARHP Annual Meeting
The CRL4CRBN E3 Ubiquitin Ligase Modulator CC-220 Inhibits BAFF-Mediated Plasmablast Differentiation and Immunoglobulin Secretion from Class Switched CD27+IgD- Memory and Lupus-Associated CD27-IgD- Double Negative B-Cells
Yumi Nakayama¹, Jolanta Kosek¹, Lori Capone², Peter H. Schafer³ and Garth Ringheim¹, ¹Inflammation and Immunology Translational Development, Celgene Corporation, Summit, NJ, ²Celgene Corporation, Summit, NJ, ³Department of Translational Development, Celgene Corporation, Summit, NJ
Background/Purpose: Changes in the ratio of circulating memory, naive, and double negative CD27-IgD- B cell subsets are associated with a higher disease activity index in…

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Abstracts tagged "Plasmablasts and antibodies"

The CRL4CRBN E3 Ubiquitin Ligase Modulator CC-220 Inhibits BAFF-Mediated Plasmablast Differentiation and Immunoglobulin Secretion from Class Switched CD27+IgD- Memory and Lupus-Associated CD27-IgD- Double Negative B-Cells