Abstracts tagged "plasma cells and toll-like receptors"

Abstract Number: 1497 • 2013 ACR/ARHP Annual Meeting
Endosomal TLR Triggering Of B Cells In Sjögren’s Syndrome Induces Increased Plasma Cells Differentiation, Ig Class Switch and Immunoglobulin Production
Marie Wahren-Herlenius¹, Susanna Brauner¹, Marika Kvarnström¹, Lasse Folkersen¹, Sabrina Görgen¹, Christina Trollmo², Vivianne Malmström³ and Gunnel Nordmark⁴, ¹Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Karolinska Institutet, Stochkolm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Background/Purpose: Patients with primary Sjögren’s syndrome have B cell disturbances resulting in hypergammaglobulinemia and autoantibody production. Most patients are not treated by immunomodulatory drugs, enabling…

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Abstracts tagged "plasma cells and toll-like receptors"

Endosomal TLR Triggering Of B Cells In Sjögren’s Syndrome Induces Increased Plasma Cells Differentiation, Ig Class Switch and Immunoglobulin Production