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Abstracts tagged "plasma cells and tolerance"

  • Abstract Number: 1834 • ACR/ARHP Annual Meeting 2017

    Selective Inhibitors of Nuclear Export Prevent Lupus Progression By Targeting Germinal Center Formation and Autoreactive Antibody Secreting Cells

    Javier Rangel-Moreno1, Jennifer Barnard2, Shelton Cochran3, Margaret Lee3, Sharon Tamir3 and Jennifer H. Anolik4, 1Medicine- Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, 2Medicine-Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 3Karyopharm Therapeutics, Newton, MA, 4Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: There is great interest in developing new treatment approaches for systemic lupus erythematosus (SLE), but the biologic therapies under investigation over the past several…

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