Abstracts tagged "plasma cells and systemic lupus erythematosus (SLE)"

Abstract Number: 869 • 2014 ACR/ARHP Annual Meeting
UBE2L3 genotype Influences Plasma Cell Proliferation in Systemic Lupus Erythematosus By Regulation of NF-κB By the Linear Ubiquitination Assembly Complex
Myles J. Lewis¹, Simon Vyse¹, Adrian M. Shields², Sebastian Boeltz², Patrick Gordon³, Timothy D. Spector⁴, Paul J. Lehner⁵, Henning Walczak⁶ and Timothy J. Vyse², ¹Experimental Medicine & Rheumatology, Queen Mary University of London, London, United Kingdom, ²Medical & Molecular Genetics, King's College London, London, United Kingdom, ³Department of Rheumatology, King's College London, London, United Kingdom, ⁴Department of Twin Research, King's College London, London, United Kingdom, ⁵Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom, ⁶Centre for Cell Death, Cancer and Inflammation, University College London, London, United Kingdom
Background/Purpose: Genome-wide association studies have identified a strong association between a single risk haplotype of the UBE2L3gene and Systemic Lupus Erythematosus (SLE), as well as…
Abstract Number: 24 • 2013 ACR/ARHP Annual Meeting
Plasma Cells In Acute Systemic Lupus Erythematosus Flares Are Characterized By a Highly Diversified Repertoire Accentuated By Clonal Expansions Of VH4-34 Antibodies
Christopher Tipton¹, Christopher Fucile², Alex Rosenberg², Scott Jenks³, Jennifer Hom⁴, F. Eun-Hyung Lee⁴ and Inaki Sanz¹, ¹Medicine/Rheumatology, Emory University, Atlanta, GA, ²University of Rochester, Rochester, NY, ³Allergy, Immunology, and Rheumatology, Emory University School of Medicine, Atlanta, GA, ⁴Emory University, Atlanta, GA
Background/Purpose :Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which faulty B cell tolerance promotes the generation of multiple autoantibodies of which anti-ds DNA,…
Abstract Number: 1449 • 2012 ACR/ARHP Annual Meeting
Numbers of Splenic Long-Lived Plasma Cells in Autoimmune and Pre-Autoimmune Lupus Mice Are Linked to a Hyper-Responsive Variant of the Thrombopoietin Receptor and Enhanced Megakaryopoiesis
Oliver Winter¹, Katrin Moser², Rudolf A. Manz³ and Falk Hiepe⁴, ¹Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, ²German Arthritis Research Center (DRFZ Berlin), Berlin, Germany, ³Institute for Systemic Inflammation Research (ISEF), University of Lübeck, Lübeck, Germany, ⁴Med. Klinik m. Sp. Rheumatologie und klin. Immunologie, Charité University Hospital Berlin, Berlin, Germany
Background/Purpose: Autoantibodies contribute to the pathogenesis of the autoimmune disease Systemic Lupus Erythematosus (SLE) by stimulating the immune response. Further, deposits of immune complexes in…

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