ACR Meeting Abstracts

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Abstracts tagged "plasma cells and signal transduction"

  • Abstract Number: 1053 • 2015 ACR/ARHP Annual Meeting

    Phosphatidylinositol-3-Kinase Delta Pathway a Novel Therapeutic Target for Sjogren’s Syndrome

    Saba Nayar1, Joana Campos1, Christopher Buckley1, Rodger Allen2, W.A. Fahy2, Andrew Payne2 and Francesca Barone1, 1University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom, 2UCB Pharma, Slough, United Kingdom

    Background/Purpose: Sjögren’s syndrome (SS) is a chronic autoimmune disease characterized by B cell hyper-activation and exocrine gland infiltration that results in loss of glandular function,…
  • Abstract Number: 920 • 2013 ACR/ARHP Annual Meeting

    Fms-Like Tyrosine Kinase 3 Signaling Is Essential For Differentiation Of Antigen Specific Plasma Cells During Experimental Arthritis

    Mattias Svensson1, Kersti MÃ¥nsson1, Karin Andersson1, Mats Bemark2, Mikael Brisslert1 and Maria Bokarewa1, 1Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, 2Microbiology and Immunology, University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Signaling through the tyrosine kinase receptor Flt3 plays an important role in early B-cell development. Mice lacking either Flt3 or its ligand (Flt3L) have…
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ACR Pediatric Rheumatology Symposium 2020

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