Abstracts tagged "phenotypes"

Abstract Number: 0478 • ACR Convergence 2021
Identification of Clinical Phenotypes of Hand Osteoarthritis Using Hierarchical Clustering Method
Marie Binvignat¹, Gabriel Pires¹, Nicolas Tchitchek¹, Alice Courties², Felicie Costantino³, David Klatzmann¹, Bernard Combe⁴, Maxime Dougados⁵, Pascal Richette⁶, Encarnita Mariotti-Ferrandiz¹, Francis Berenbaum⁷ and Jeremie Sellam⁸, ¹Sorbonne Universite, Paris, France, ²Service de Rhumatologie, AP-HP Hopital Saint-Antoine, Sorbonne Universite, INSERM, Centre de Recherche Saint-Antoine, Paris, France, ³Inserm, Boulogne Billancourt, France, ⁴CHU Montpellier Montpellier University, Montpellier, France, ⁵Université de Paris . Department of Rheumatology - Hôpital Cochin. Assistance Publique - Hôpitaux de Paris . INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité. Paris, France., Paris, France, ⁶Lariboisiere Hospital, Paris, France, ⁷Sorbonne Universit - hopital Saint-Antoine, Paris, France, ⁸INSERM UMRS_938, Sorbonne Université, St-Antoine Hospital, Paris, France, Paris, France
Background/Purpose: Hand osteoarthritis (OA) is an heterogenous disease in terms of risk factors, localization and severity. This heterogeneity also applies to the clinical presentation and…
Abstract Number: 054 • 2020 Pediatric Rheumatology Symposium
Clinical and Laboratory Characteristics in Juvenile-onset Systemic Lupus Erythematosus Across Age Groups
Joseph Massias ¹, Eve Smith ¹, Michael Beresford ¹ and Christian Hedrich¹, ¹University of Liverpool, Liverpool, United Kingdom
Background/Purpose: Systemic lupus erythematous (SLE) is a systemic autoimmune/inflammatory condition. Up to 20% of patients develop symptoms before their 18th birthday and are diagnosed with…
Abstract Number: 2850 • 2019 ACR/ARP Annual Meeting
Exploring Heterogeneity in Rheumatoid Arthritis: Outcomes up to 4 Years of Follow-Up in Patient Clusters Identified by Data-driven Analysis of the BRASS Registry
Jeffrey Curtis¹, Michael Weinblatt ², Kenneth Saag ¹, Vivian Bykerk ³, Christina Charles-Schoeman ⁴, Stefano Fiore ⁵, Gregory St John ⁶, Toshio Kimura ⁷, Shen Zheng ⁵, Clifton Bingham ⁸, Grace Wright ⁹, Martin Bergman ¹⁰, Kamala Nola ¹¹, Daniel Furst ⁴ and Nancy Shadick ², ¹University of Alabama at Birmingham, Birmingham, AL, ²Brigham and Women's Hospital, Boston, MA, ³Hospital for Special Surgery, New York City, NY, ⁴University of California, Los Angeles, CA, ⁵Sanofi Genzyme, Bridgewater, NJ, ⁶Regeneron Pharmaceuticals, Inc., Tarrytown, NY, ⁷Regeneron Pharmaceuticals, Inc, Tarrytown, NY, ⁸Johns Hopkins University, Baltimore, MD, ⁹Private Practice, New York City, NY, ¹⁰Drexel University College of Medicine, Stockholm, Sweden, ¹¹Lipscomb University College of Pharmacy & Health Sciences, Nashville, TN
Background/Purpose: Patients with rheumatoid arthritis (RA) may share characteristics that relate to their future outcomes. We investigated clinical outcomes over a 4-year follow-up period in…
Abstract Number: 2021 • 2019 ACR/ARP Annual Meeting
Higher Genetic Risk Load in Patients with More Diverse Manifestations in a Korean Systemic Lupus Erythematosus Cohort
So-Young Bang¹, Eunji Ha ², Hyuk-Hee Kwon ³, Hyun-Seung Yoo ⁴, Juyeon Kang ¹, Ji-Soong Kim ¹, Bora Nam ¹, Jung-Min Shin ¹, Yeon-Kyung Lee ¹, Tae-Han Lee ⁵, Hye-Soon Lee ⁶, Kwangwoo Kim ² and Sang-Cheol Bae ¹, ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ²Kyung Hee University, Seoul, Republic of Korea, ³Hanyang University Hospital, Guri, ⁴Hanyang University Hospital, Guri, Republic of Korea, ⁵Hanyang University, Seoul, ⁶Department of Internal Medicine, Hanyang University Guri Hospital,Hanyang University School of Medicine, Guri, Korea, Guri, Republic of Korea
Background/Purpose: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease with diverse heterogeneous phenotypes. Although many studies of SLE presented estimates of high heritability, impact…
Abstract Number: 1064 • 2018 ACR/ARHP Annual Meeting
Identification of a Panel of Circulating Proteins Associated to Synovial Pathotypes in Early Rheumatoid Arthritis Patients
Cristina Ruiz-Romero¹, Florencia Picchi², Patricia Fernández³, Lucia González², Rebecca Hands⁴, Valentina Calamia², Maria Camacho², Conrad Bessant⁵, Costantino Pitzalis⁴ and Francisco J Blanco⁶, ¹Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Rheumatology Research Group, Proteomics Unit-ProteoRed/ISCIII, INIBIC-CHUAC, A Coruña, Spain, ³Proteomics group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, La Coruña, Spain, ⁴Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁵School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom, ⁶Rheumatology Divison, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain
Background/Purpose: Rheumatoid arthritis (RA) is characterized by high clinical variability and an underlying cellular and molecular heterogeneity. Efforts to find tools for the classification of…
Abstract Number: 2949 • 2018 ACR/ARHP Annual Meeting
African American and European American SLE Patients with Variable Disease Activity Reveal Distinct Differences in B Cells and TLR7/8 Pathways
Samantha Slight-Webb¹, Miles C. Smith¹, Holden T. Maecker², Paul J. Utz³, Joel M. Guthridge¹ and Judith A. James⁴, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Stanford University, Stanford, CA, ³Medicine, Stanford University School of Medicine, Stanford, CA, ⁴Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disorder with a heterogeneous clinical presentation and periods of waxing and waning disease. Heterogeneity in SLE is…
Abstract Number: 1639 • 2017 ACR/ARHP Annual Meeting
Longitudinal Evolution in a Nationwide Cohort Originally Classified As Mixed Connective Tissue Disease
Silje Reiseter¹, Ragnar Gunnarsson², Jukka Corander³, Johanna Haydon⁴, May Brit Lund⁵ and Øyvind Molberg¹, ¹Oslo University Hospital, Oslo, Norway, ²Department of Rheumatology, Oslo University Hospital, Oslo, Norway, OSLO, Norway, ³Departement of Biostatistics, University of Oslo, Oslo, Norway, ⁴Rheumatology, Vestre Viken Hospital, Drammen, Norway, ⁵Respiratory Medicine, Oslo University Hospital, Oslo, Norway
Background/Purpose: Ever since Mixed Connective Tissue Disease was presented as a distinct entity in 1972, it has been discussed whether MCTD represents an undifferentiated, transient…
Abstract Number: 2574 • 2017 ACR/ARHP Annual Meeting
Interleukin-33 Ameliorates Murine Lupus Via Induction of Regulatory T Cells and M2 Macrophage Polarisation
Mo Yin Mok¹, Ka Sin Law², Wing Yin Kong¹, Ge Liu¹, Wallace Lau², C Luo², FP Huang³, GC Chan⁴ and Kwok Wah Chan³, ¹Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, Hong Kong, ²Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong, ³Department of Pathology, University of Hong Kong, Hong Kong, Hong Kong, ⁴Department of Paediatrics, University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: The levels of IL-33, a Th2 promoting cytokine, and the soluble form of its receptor ST2 were reported to be elevated in serum of…
Abstract Number: 125 • 2016 ACR/ARHP Annual Meeting
Increased Hypertension and Renal Disease in African Americans Compared to Caucasians with Systemic Lupus Erythematosus
April Barnado¹, Robert Carroll², Carolyn Casey¹, Joshua C. Denny² and Leslie J. Crofford³, ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, ³Medicine, Vanderbilt University Medical Center, Nasville, TN
Background/Purpose: African Americans have higher rates of SLE and SLE nephritis compared to Caucasians. These epidemiologic associations come mainly from cohort studies that collect standardized…
Abstract Number: 2879 • 2016 ACR/ARHP Annual Meeting
Genome-Wide Pathway Analysis Reveals That VEGF Genetic Pathway Is Associated with Oral Ulcers in Systemic Lupus Erythematosus
Antonio Julià¹, Patricia Carreira², Ricardo Blanco³, Victor Martinez Taboada⁴, Luis Carreño⁵, Jose Javier Perez Venegas⁶, Alejandro Olivé⁷, Jose Luis Andreu⁸, Maria Ángeles Aguirre Zamorano⁹, Paloma Vela¹⁰, Joan Miquel Nolla¹¹, José Luis Marenco de la Fuente¹², Antonio Zea¹³, JM Pego-Reigosa¹⁴, Mercedes Freire¹⁵, Elvira Diez Alvarez¹⁶, Adrìa Aterido¹, Arnald Alonso¹, Maria López-Lasanta¹⁷, Mireia López¹⁸, Raül Tortosa¹, Sara Marsal¹⁹ and Antonio Fernandez-Nebro²⁰, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ³Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ⁴Hospital Marqués de Valdecilla., Santander, Spain, ⁵Rheumatology, HGU Gregorio Marañón, Madrid, Spain, ⁶Rheumatology, Hospital de Jerez de la Frontera, Jerez de la Frontera, Spain, ⁷Rheumatology, Hospital Universitario Germans Trias i Pujol, Barcelona, Spain, ⁸Rheumatology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain, ⁹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ¹⁰Dpt. Rheumatology, Hospital General Universitario Alicante, Alicante, Spain, ¹¹Rheumatology, Bellvitge University Hospital, Barcelona, Spain, ¹²Rheumatology, Hospital de Valme, Seville, Spain, ¹³Hospital Ramón y Cajal. Madrid, Madrid, Spain, ¹⁴Rheumatology Section, Hospital de Meixoeiro, Pontevedra, Spain, Vigo, Spain, ¹⁵Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo HospitalarioUniversitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ¹⁶Rheumatology, Hospital de León, León, Spain, ¹⁷Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ¹⁸Servicio de Reumatología, Hospital Universitario Vall d´Hebron, Barcelona, Spain, ¹⁹Rheumatology Research Unit, Vall d'Hebron Hospital, Barcelona, Spain, ²⁰Rheumatology, Hospital Universitario Carlos Haya, Malaga, Spain
Background/Purpose: Systemic lupus erythematosus (SLE) is a genetically complex rheumatic disease with heterogeneous clinical manifestations. Recent studies have suggested the existence of a genetic basis…
Abstract Number: 797 • 2015 ACR/ARHP Annual Meeting
Divergent Phenotypic Patterns Between Systemic Lupus Erythematosus and Healthy Anti-Nuclear Antibody Positive Individuals Reveal Distinct Differences in B Cell and Myeloid Populations Among Ethnicities
Samantha Slight-Webb¹, Rufei Lu², Holden T. Maecker³, Paul J. Utz⁴, Joel M. Guthridge¹ and Judith A. James⁵, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Medicine, Stanford University School of Medicine, Stanford, CA, ⁵Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disorder that arises from genetic and environmental factors. Thus, patients with different ancestral backgrounds display differences in…
Abstract Number: 2200 • 2015 ACR/ARHP Annual Meeting
Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking Clinical Database and Repository Cluster Analysis: Identification of Different Clinical Phenotypes Among Antiphospholipid Antibody-Positive Female Patients
Stephane Zuily¹, Cecilia B. Chighizola², DENIS WAHL¹, Pier Luigi Meroni³ and Doruk Erkan⁴, ¹CHU de Nancy, Vascular Medicine Division and Regional Competence Centre For Rare Vascular And Systemic Autoimmune Diseases; and UMR_S U1116 Research Unit, France, Nancy, France, ²Department of Clinical Sciences and Community Health, University of Milan, Istituto Auxologico Italiano, Cusano Milanino, Italy, ³University of Milan, Department of Clinical Sciences and Community Health, Division of Rheumatology, Gaetano Pini Institute, Milan, Italy, ⁴Barbara Volcker Center for Women & Rheumatic Disease, Hospital for Special Surgery, New York, NY
Background/Purpose: APS ACTION International Clinical Database and Repository was created to study the natural course of persistently antiphospholipid antibodies (aPL)-positive patients ± autoimmune disorders over…
Abstract Number: 2697 • 2015 ACR/ARHP Annual Meeting
Phenome-Wide Association Study of Rheumatoid Arthritis Subgroups Identifies Association Between Seronegative Disease and Fibromyalgia
Jayanth Doss¹, Huan Mo², Leslie J. Crofford¹ and Joshua C. Denny², ¹Rheumatology, Vanderbilt University School of Medicine, Nashville, TN, ²Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN
Background/Purpose: The differences between seronegative and seropositive rheumatoid arthritis (RA) have not been widely reported. We performed an electronic health record (EHR)-based phenome-wide association study…
Abstract Number: 1718 • 2014 ACR/ARHP Annual Meeting
B Cell Subsets Homeostasis and Functional Properties Are Altered in a Murine Model of Systemic Sclerosis
Sébastien Sanges^1,2,3, Niloufar Kavian⁴, Carine Hauspie^1,3,5, Carole Nicco⁴, Thomas Guerrier^1,3, Virginie Dutoit-Lefèvre^1,3, Guillaume Lefèvre^1,2,5,6, Alexandra Forestier^1,2,3, Vincent Sobanski^1,2,6, Christelle Faveeuw⁷, Myriam Labalette^1,3,5, Frédéric Batteux⁴, David Launay^1,2,3 and Sylvain Dubucquoi^1,3,5, ¹Université Lille Nord de France, Faculté de Médecine Henri Warembourg, Lille, Lille, France, ²Service de médecine interne, Centre National de Référence de la Sclérodermie Systémique, Hôpital Claude Huriez, CHRU Lille, Lille, France, ³EA 2686, Lille, Lille, France, ⁴Université Paris Descartes, EA 1833, Hôpital Cochin, AP-HP, Paris, Paris, France, ⁵Institut d’Immunologie, Centre de Biologie-Pathologie-Génétique, CHRU Lille, Lille, France, ⁶EA 2686, Lille, LILLE, France, ⁷Institut National de la Santé et de la Recherche Médicale Unité 547, Institut Pasteur de Lille, Institut Fédératif de Recherche 142, Université de Lille Nord de France, Lille, France
Background/Purpose Systemic sclerosis (SSc) is a multi-organ fibrotic disease associated with auto-immune abnormalities. Several clinical and experimental observations suggest that B cells are involved in…
Abstract Number: 835 • 2014 ACR/ARHP Annual Meeting
Relapsing Polychondritis Can be Characterized By 3 Different Clinical Phenotypes: Analysis of a Series of 142 Patients
Jeremie Dion¹, Nathalie Costedoat-Chalumeau¹, Damien Sène², Judith Cohen-Bittan³, Gaëlle Leroux⁴, Charlotte Dion⁵, Camille Francès⁶ and Jean-Charles Piette⁷, ¹Internal medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ²Hopital Lariboisière, service de Médecine Interne, Paris, France, ³Service de medecine gériatrique, CHU Pitié-Salpêtrière, Paris, France, ⁴Department of Internal Medicine 1, CHU Pitié-Salpêtrière, Paris, France, ⁵Ecole des hautes études en sciences sociales, Paris, France, ⁶service de dermatologie allergologie, Hôpital Tenon, Paris Cedex 20, France, ⁷Department of Internal Medicine 1., CHU Pitié-Salpêtrière, Paris, France
Background/Purpose We previously described clinical characteristics and evolution of 142 patients with relapsing polychondritis (RP) followed in a single center and seen at least once…

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