ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "pharmacology and safety"

  • Abstract Number: 1922 • 2018 ACR/ARHP Annual Meeting

    Characterization of the Pharmacology and Pharmacokinetics of Cntx-4975, a High-Purity, Synthetic Trans-Capsaicin in Clinical Development for the Treatment of Moderate to Severe OA Knee Pain

    James Campbell, Randall Stevens and Peter Hanson, Centrexion Therapeutics, Boston, MA

    Background/Purpose: CNTX-4975, a highly purified, synthetic trans-capsaicin and long-acting, non-opioid analgesic in phase 3 trials for moderate to severe OA knee pain, has demonstrated safety…
  • Abstract Number: 1610 • 2016 ACR/ARHP Annual Meeting

    Safety, Tolerability, and Dose-Dependent Inhibition of T-Cell-Dependent Antibody Response with MEDI4920, a Novel, Engineered CD40L Antagonist: Results of a Single-Ascending Dose Study in Healthy Volunteers

    Marius Albulescu1, Jim Bush2, Firas Almazedi2, Ethan Grant3, Alex Godwood1, Robert Miday4, Krista Arbaugh4, Lisa H. Butler1, Michele Gunsior4, Jing Li5 and David Howe1, 1MedImmune, Cambridge, United Kingdom, 2Covance Clinical Research Unit, Leeds, United Kingdom, 3Translational Medicine, MedImmune, Gaithersburg, MD, 4MedImmune, Gaithersburg, MD, 5MedImmune, Mountain View, CA

    Background/Purpose: The CD40L/CD40 co-stimulatory pathway is important for T-cell-dependent antibody production. Previous clinical programs with intact monoclonal antibodies against CD40L have been discontinued due to…
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ACR Pediatric Rheumatology Symposium 2020

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