ACR Meeting Abstracts

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Abstracts tagged "pharmacokinetics and tofacitinib"

  • Abstract Number: 388 • 2016 ACR/ARHP Annual Meeting

    Pharmacokinetics, Safety, and Tolerability of Tofacitinib in Pediatric Patients from Two to Less Than Eighteen Years of Age with Juvenile Idiopathic Arthritis

    Hermine I. Brunner1, Nicolino Ruperto2, Anasuya Hazra3, Ronnie Wang4, Charles Mebus4, Christine Alvey4, Manisha Lamba4, Sriram Krishnaswami4, Thomas C Stock3, Umberto Conte5, Min Wang5, Nikolay Tzaribachev6, Ivan Foeldvari7, Gerd Horneff8, Daniel Kingsbury9, Elena Koskova10, Elzbieta Smolewska11, Richard K Vehe12, Zbigniew Zuber13, Daniel J Lovell1 and Alberto Martini2, 1Pediatric Rheumatology Collaborative Study Group, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Istituto Giannina Gaslini, Genoa, Italy, 3Pfizer Inc, Collegeville, PA, 4Pfizer Inc, Groton, CT, 5Pfizer Inc, New York, NY, 6Pediatric Rheumatology Research Institute, Bad Bramstedt, Bad Bramstedt, Germany, 7Hamburger Zentrum für Kinder- und Jugendrheumatologie, Hamburg, Germany, 8Asklepios Klinik, Sankt Augustin, Germany, 9Randall Children's Hospital, Portland, OR, 10National Institute of Rheumatic Diseases, Piestany, Piestany, Slovakia, 11Department of Pediatric Cardiology and Rheumatology, Medical University of Lodz, Lodz, Poland, 12University of Minnesota Masonic Children’s Hospital, Minneapolis, MN, 13St Louis Children’s Hospital ODS Rheumatology and Neurology, Krakow, Poland

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor that is being investigated for juvenile idiopathic arthritis (JIA). Here, we report the pharmacokinetics (PK), safety, and…
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