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Abstracts tagged "pharmacokinetics and therapeutic targeting"

  • Abstract Number: 1881 • ACR/ARHP Annual Meeting 2016

    Targeting Oncostatin M in the Target Tissue: Assessment of in-Vivo Affinity and Target Engagement of an Anti-OSM Monoclonal Antibody By Combining Blood and Skin Blister Fluid Data

    Juliet Reid1, Stefano Zamuner2, Ken Edwards3, Sally Rumley4, Katherine Sully5, Maria Feeney6, Subramanya Kumar7, Disala Fernando7 and Nicolas Wisniacki1, 1ImmunoImflammation, GlaxoSmithKline, Stevenage, United Kingdom, 2Clinical Pharmacology, GlaxoSmithKline, Stevenage, United Kingdom, 3Statistics, GlaxoSmithKline, Stevenage, United Kingdom, 4Clinical Platforms and Sciences, GlaxoSmithKline, Stevenage, United Kingdom, 5Biopharm Translational Medicine, GlaxoSmithKline, Stevenage, United Kingdom, 6Biopharm Research, GlaxoSmithKline, Stevenage, United Kingdom, 7Clinical Unit Cambridge, GlaxoSmithKline, Cambridge, United Kingdom

    Background/Purpose: Oncostatin M (OSM) is a pleiotropic member of the gp130/IL-6 cytokine family involved in pathological processes of fibrosis, inflammation and vasculopathy. Diffuse cutaneous systemic…
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