ACR Meeting Abstracts

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Abstracts tagged "Pharmacoepidemiology"

  • Abstract Number: 2529 • ACR Convergence 2023

    Comparative Effectiveness of Denosumab versus Zoledronic Acid Among Postmenopausal Women with Osteoporosis in the U.S. Medicare Program

    Jeffrey R Curtis1, Tarun Arora2, Ye Liu3, Vanessa C. Brunetti4, Tzu-Chieh Lin4, Leslie Spangler4, Robert K. Stad4, Michele McDermott4, Brian D. Bradbury4 and Min Kim4, 1Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, 2Foundation for Advancing Science, Technology, Education, and Research, Birmingham, AL, 3University of Alabama at Birmingham, Birmingham, AL, 4Amgen, Inc., Thousand Oaks, CA

    Background/Purpose: Although clinical trials have shown that denosumab (Dmab) significantly increases bone mineral density at key skeletal sites more than zoledronic acid (ZA), evidence from…
  • Abstract Number: 0811 • ACR Convergence 2023

    Comparative Effectiveness of Sodium-glucose cotransporter-2 Inhibitors for Recurrent Gout Flares and Gout-primary Emergency Department Visits and Hospitalizations: A General Population Cohort Study

    Natalie McCormick1, Chio Yokose2, Jie Wei3, Na Lu4, Deborah Wexler1, Mary De Vera5, J. Antonio Avina-Zubieta4, Yuqing Zhang6 and Hyon K. Choi7, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Waltham, MA, 3Health Management Center, Xiangya Hospital Central South University, Changsha, China, 4Arthritis Research Canada, Vancouver, BC, Canada, 5University of British Columbia, Vancouver, BC, Canada, 6Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 7Massachusetts General Hospital and Harvard Medical School, Lexington, MA

    Background/Purpose: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) lower serum urate (primary prevention); however, whether this translates into preventing recurrent flares among gout patients (secondary prevention) and gout-primary…
  • Abstract Number: 2538 • ACR Convergence 2023

    Safety and Efficacy of Sodium-glucose Co-transporter 2 Inhibitors in Patients with Psoriasis and Concomitant Type 2 Diabetes Mellitus: A Population-based Cohort Study

    Pin-Chia Huang1, Debby Cheng2, Megan H Noe3, Jui-En Lo4, Steven T Chen3 and Kevin Sheng-Kai Ma5, 1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 2Harvard Medical School, Boston, MA, 3Department of Dermatology, Massachusetts General Hospital, Boston, MA, 4Center for Global Health, Perelman School of Medicine, Philadelphia, PA, 5Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Psoriasis and type 2 diabetes mellitus (T2D) may share common underlying pathophysiology, in which the pathogenesis of psoriasis is mediated by NOD-like receptor family…
  • Abstract Number: 0853 • ACR Convergence 2023

    Early Experience with Avacopan for ANCA-Associated Vasculitis in a Large Integrated Healthcare System

    Shruthi Srivatsan1, Zachary Williams1, Claire Cook1, Xiaoqing Fu1, Naomi Patel1 and Zachary Wallace2, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Newton, MA

    Background/Purpose: ANCA-associated vasculitis (AAV) is a small-to-medium vessel vasculitis associated with substantial morbidity and mortality, in part due to glucocorticoid exposure. Avacopan, an oral C5a…
  • Abstract Number: 1103 • ACR Convergence 2023

    Evaluation of Outcomes Following Discontinuation of Pegloticase Therapy

    Emily Holladay1, Amy S. Mudano2, Fenglong Xie2, Jingyi Zhang1, Ted R Mikuls3, Brian LaMoreaux4, Lissa Padnick-Silver4 and Jeffrey Curtis1, 1University of Alabama at Birmingham, Birmingham, AL, 2Illumination Health, Hoover, AL, 3Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, 4Horizon Therapeutics, Deerfield, IL

    Background/Purpose: Little is known about the long-term effects of pegloticase therapy or what urate-lowering therapy (ULT) patients subsequently receive when they discontinue pegloticase. This analysis…
  • Abstract Number: 1340 • ACR Convergence 2023

    Recent Trends in Treatment Patterns for Rheumatoid Arthritis in Response to Emerging Data

    Stephanie Song1, Michael George2, Ted R Mikuls3, Bryant England4, Brian Sauer5, Grant Cannon6 and Joshua Baker2, 1Hospital of the University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, 4University of Nebraska Medical Center, Omaha, NE, 5Salt Lake City VA/University of Utah, Salt Lake City, UT, 6University of Utah and Salt Lake City VA, Salt Lake City, UT

    Background/Purpose: Janus kinase inhibitors (JAKi) have demonstrated substantial efficacy in decreasing symptoms and in reducing progressive joint damage in patients with rheumatoid arthritis (RA). In…
  • Abstract Number: 1386 • ACR Convergence 2023

    Opioid Prescription Rates in Patients with Ankylosing Spondylitis in the UK Between 2001-2020: An Electronic Health Records (EHR) Analysis

    Huseyin Berk Degirmenci1, Christine E. Peloquin2, Sara Lodi2, Pedro Machado3, S. Reza Jafarzadeh4, Tuhina Neogi5, Lianne Gensler6, Maureen Dubreuil7 and Jean Liew2, 1St. Elizabeth's Medical Center, Boston, MA, 2Boston University, Boston, MA, 3Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, UK. Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS trust, London, UK., London, United Kingdom, 4Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 5Boston University School of Medicine, Boston, MA, 6University of California San Francisco, Department of Medicine, Division of Rheumatology, San Francisco, CA, 7Department of Rheumatology, Boston University School of Medicine, Milton, MA

    Background/Purpose: Although current axial spondyloarthritis (axSpA) management guidelines do not address opioid use for chronic pain, available data show that opioid use is common among…
  • Abstract Number: 1515 • ACR Convergence 2023

    Performance of the Revised CRISS in a Phase 3 Trial of Early Systemic Sclerosis

    Dinesh Khanna1, Christopher Denton2, Masataka Kuwana3, Daniel Furst4, Suiyuan Huang1, Barbara White5 and Robert Spiera6, 1University of Michigan, Ann Arbor, MI, 2University College London, London, United Kingdom, 3Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 4University of California Los Angeles, Los Angeles, CA, 5SFJ Pharmaceuticals, Towson, MD, 6Hosptial for Special Surgery, New York, NY

    Background/Purpose: Revised CRISS has been proposed an approvable outcome measure in early diffuse cutaneous SSc (dcSSc)1. The index is undergoing the FDA review as part…
  • Abstract Number: 1582 • ACR Convergence 2023

    Non-TNFi b/tsDMARDs vs. TNFi in Rheumatoid Arthritis-Interstitial Lung Disease: An Active-Comparator, New-User, Propensity Score Matched Study Using National Veterans Affairs Data

    Bryant England1, Joshua Baker2, Michael George2, Tate Johnson1, Yangyuna Yang1, Punyasha Roul1, Harlan Sayles1, Fang Yu1, Jorge Rojas Jr3, Brian Sauer4, Grant Cannon5, Jeffrey R Curtis6 and Ted R Mikuls7, 1University of Nebraska Medical Center, Omaha, NE, 2University of Pennsylvania, Philadelphia, PA, 3Puget Sound VA and University of Utah, Seattle, WA, 4Salt Lake City VA/University of Utah, Salt Lake City, UT, 5University of Utah and Salt Lake City VA, Salt Lake City, UT, 6Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, 7Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: There is a paucity of data to guide biologic and JAKi DMARD selection in rheumatoid arthritis-interstitial lung disease (RA-ILD), with some reports of higher…
  • Abstract Number: 109 • 2023 Pediatric Rheumatology Symposium

    Long-term Safety of Biologics versus Conventional Synthetic Treatments in Systemic Juvenile Idiopathic Arthritis Patients

    Ana Isabel Rebollo-Giménez1, Luca Carlini2, Yulia Vyzhga3, Silvia Rosina4, Ekaterina Alexeeva5, Charlotte Myrup6, Silvia Magni Manzoni7, Maria Trachana8, Valda Stanevicha9, Constantin Ailioaie10, Elena Tsitsami11, Alexis-Virgil Cochino12, Chiara Pallotti13, Silvia Scala13, Angela Pistorio14, Sebastiaan Vastert15, Joost F. Swart16 and Nicolino Ruperto17, 1IRCCS Istituto Giannina Gaslini, UOC Reumatologia e Malattie Infiammatorie, Genova, Italy, 2IRCCS Istituto Giannina Gaslini, UOC Reumatologia e Malattie Autoinfiammatorie, Genova, Italy, 3IRCCS Istituto Giannina Gaslini, UOC Reumatologia e Malattia Infiammatorie, Genova, Italy, 4IRCCS Istituto Giannina Gaslini, Genova, Italy, 5Federal State Autonomous Institution “National Medical Research Center of Children's Health”, Ministry of Health of the Russian Federation, Moscow, Russia, 6Rigshospitalet, Pediatric rheumatology unit 4272, Copenhagem, Denmark, 7IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Roma, Italy, 8Hippokration General Hospital, Thessaloniki University School of Medicine, First Department of pediatrics, Pediatric Immunology and Rheumatology Referral Center, Thessaloniki, Greece, 9Riga Stradins University, Children University Hospital, Riga, Latvia, 10Alexandru Ioan Cuza University of Iasi, Iasi, Romania, 11Aghia Sophia Childrens Hospital, First Department of Pediatrics, University of Athens Medical School, Athens, Greece, 12Institute for Mother and Child Care, Pediatrics, Bucharest, Romania, 13IRCCS Istituto Giannina Gaslini, U.O.C. Pediatric and Rheumatology Clinic, PRINTO, Genova, Italy, 14IRCCS Istituto Giannina Gaslini, Direzione Scientifica, Genova, Italy, 15Wilhelmina Children’s Hospital, Department of Pediatric Immunology and Rheumatology, Utrecht, The Netherlands, Utrecht, Netherlands, 16Wilhelmina Children’s Hospital, Department of Pediatric Immunology and Rheumatology, Utrecht, Netherlands, 17IRCCS Istituto Giannina Gaslini, UOSID Centro Trial, PRINTO, Genova, Italy

    Background/Purpose: The better understanding of systemic Juvenile Idiopathic Arthritis (sJIA) pathogenesis and availability of new drugs, such as biologic disease-modifying anti-rheumatic drugs (bDMARDs) specifically dedicated…
  • Abstract Number: 0862 • ACR Convergence 2022

    Impact of the COVID-19 Pandemic on the Management of Juvenile Idiopathic Arthritis: An Analysis of National United States Administrative Claims Data

    Daniel Horton1, Yiling Yang2, Amanda Neikirk2, Cecilia Huang3, Stephen Crystal4, amy davidow5, Kevin Haynes6, Tobias Gerhard7, Carlos Rose8, Brian Strom9 and Lauren Parlett2, 1Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 2HealthCore, Wilmington, DE, 3Rutgers Center for Pharmacoepidemiology and Treatment Science, New Brunswick, NJ, 4Rutgers Center for Health Services Research, New Brunswick, NJ, 5New York University, New York, NY, 6Johnson & Johnson, Titusville, NJ, 7Ernest Mario School of Pharmacy, Rutgers University, New Brunswick, NJ, 8Nemours, Chadds Ford, PA, 9Rutgers Biomedical and Health Sciences, Newark, NJ

    Background/Purpose: Limited information exists on COVID-19 pandemic-related changes in the management of rheumatic diseases in adults or children, besides what patients and families have reported.…
  • Abstract Number: 0925 • ACR Convergence 2022

    Impact of Initiating Biologic and Targeted Synthetic Disease-Modifying Antirheumatic Drugs on Pain Medication Use in Patients with Rheumatoid Arthritis

    Mengdong He1, Yvonne Lee2, Yinzhu Jin3, Rishi Desai3, Seanna Vine3 and Seoyoung Kim3, 1UCLA David Geffen School of Medicine, Los Angeles, CA, 2Northwestern University, Chicago, IL, 3Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Chronic pain associated with rheumatoid arthritis (RA) leads to impaired patient function and quality of life. Prior studies suggest initiation of disease-modifying antirheumatic drugs…
  • Abstract Number: 1112 • ACR Convergence 2022

    Biosimilar-to-Biosimilar Switching in Routine Care – Results on >1,600 Patients with Inflammatory Arthritis in the DANBIO Registry

    Hafsah Nabi1, Oliver Hendricks2, Dorte Vendelbo Jensen3, Anne Gitte Loft4, Jens Pedersen5, Søren Just6, Kamilla Danebod7, Heidi Munk8, Salome Kristensen9, Natalia Manilo10, Ada Colic11, Asta Linauskas12, Pia Høger Thygesen13, Louise Christensen3, Maren Høgberget Kalisz3, Niels Lomborg14, Stavros Chrysidis15, Johnny Raun15, Marlene Andersen16, Frank Mehnert17, Niels Steen Krogh18, Merete L Hetland19 and Bente Glintborg20, 1DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, Copenhagen, Denmark, 2Danish Hospital For Rheumatic Diseases, Sønderborg, Denmark, 3Department of Rheumatology, Gentofte and Herlev Hospital, Copenhagen University Hospital, Gentofte, Denmark, 4Aarhus University, Horsens, Denmark, 5Svendborg Hospital, Odense University Hospital, Odense, Denmark, 6Medicinsk Afdeling Svendborg Sygehus OUH, Odense, Denmark, 7Department of Rheumatology, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark, 8Department of Rheumatology, Odense University Hospital, Odense, Denmark, Odense, Denmark, 9Center of Rheumatic Research Aalborg, Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark, 10Department of Rheumatology, Frederiksberg Hospital, Copenhagen, Denmark, 11Department of Rheumatology, Zealand University Hospital, Køge, Denmark, 12North Denmark Regional Hospital, Hjørring, Denmark, 13Department of Rheumatology, Slagelse Hospital, Slagelse, Denmark, 14Department of Rheumatology, Vejle Hospital Lillebælt, Vejle, Denmark, Odense, Denmark, 15Department of Rheumatology, Esbjerg Hospital, Esbjerg, Denmark, 16Department of Rheumatology, North Denmark Regional Hospital, Hjørring, Denmark, 17Aarhus University Hospital, Aarhus, Denmark, 18ZiteLab ApS, Frederiksberg, Denmark, 19Rigshospitalet, Glostrup, Denmark, 20Rigshospitalet, Glostrup, Virum, Denmark

    Background/Purpose: In routine care, biosimilar-to-biosimilar infliximab switching may occur to save costs (=non-medical switching). Previous studies have investigated the efficacy and safety of switches from…
  • Abstract Number: 1199 • ACR Convergence 2022

    Validation of New Medication User Definitions in Single-Specialty EHR Data

    Jeffrey Curtis1, Yujie Su2, Michael george3, Cassie Clinton2, Patrick Stewart4, Tim Buekelman5 and Fenglong Xie2, 1Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3UPENN, Philadelphia, PA, 4Bendcare, Boca Raton, FL, 5FASTER, Hoover, AL

    Background/Purpose: New user designs are standard in many pharmacoepidemiology studies, but a first prescription appearance in electronic health record (EHR) data may not always represent…
  • Abstract Number: 1213 • ACR Convergence 2022

    Trends of Opioid Prescriptions and Impact of the COVID-19 Pandemic Among Patients with Musculoskeletal Diseases Between 2006-2021

    Joyce (Yun-Ting) Huang1, David Jenkins2, Belay Birlie Yimer1, Jose Benitez-Aurioles2, Niels Peek2, Mark Lunt1, Will Dixon3 and Meghna Jani1, 1Centre for Epidemiology Versus Arthritis, The University of Manchester, Manchester, United Kingdom, 2Division of Informatics, The University of Manchester, Manchester, United Kingdom, 3The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Opioid prescribing has contributed to a North American epidemic with increasing trends in several European countries. Rheumatic and musculoskeletal diseases (RMDs) are one of…
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