phagocytosis and systemic lupus erythematosus (SLE) Archives

Abstract Number: 2844 • ACR/ARHP Annual Meeting 2014
Intracellular Complement C3 Is Exposed on the Cell Surface upon Apoptosis Induction and Participates in the Clearance of Apoptotic Cells By Phagocytes
Lucrezia Colonna¹, Christian Lood¹, YuFeng Peng², Xizhang Sun³, Lena Tanaka³, Sandip Panicker⁴ and Keith B. Elkon³, ¹Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Rheumatology, University of Washington, Seattle, WA, ³Division of Rheumatology, University of Washington, Seattle, WA, ⁴True North Therapeutics, South San Francisco, CA
Background/Purpose The complement system has been viewed as a predominantly serum-derived host defense mechanism with multiple functions, including clearance of apoptotic cells. Defective function of…
Abstract Number: 2544 • ACR/ARHP Annual Meeting 2013
Serum Mediated Phagocytosis Of Necrotic Material By Polymorphonuclear Leukocytes May Be Used As a Tool To Predict Clinical Manifestations In Systemic Lupus Erythematosus
Michele Compagno¹, Birgitta Gullstrand², Andreas Jönsen³, Lennart Truedsson², Gunnar Sturfelt⁴ and Anders A. Bengtsson³, ¹Department of clinical sciences - Rheumatology, Lund University, Lund, Sweden, ²Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden, ³Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, ⁴Department of Clinical Sciences Lund, Section of Rheumatology, Lund University, Lund, Sweden
Background/Purpose: Polymorphonuclear (PMNs) leukocytes with engulfed necrotic cell material (NCM), as formerly used in the LE-cell test, are frequently seen in SLE and associated to…
Abstract Number: 2526 • ACR/ARHP Annual Meeting 2012
Bruton′s Tyrosine Kinase and Calreticulin: A Novel Interaction with Implications for Inflammatory and Autoimmune Disease
Jennifer C. Byrne¹, Joan Ní Gabhann¹, Kevin Stacey¹, Barbara M. Coffey¹, Eoghan M. McCarthy², Warren Thomas³, Eamonn Molloy⁴, Grainne M. Kearns⁵ and Caroline Jefferies¹, ¹Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland, ²Rheumatology, Beaumont Hospital, Dublin, Ireland, ³Molecular Medicine, Royal College of Surgeons in Ireland, Dublin 9, Ireland, ⁴Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ⁵Rheumatology Department, Beaumont Hospital, Dublin, Ireland
Background/Purpose: Bruton’s Tyrosine Kinase (Btk) regulates innate immune responses downstream of multiple Toll-like receptors (TLRs), including TLR7. Given the role of TLR7 in driving type…
Abstract Number: 2250 • ACR/ARHP Annual Meeting 2012
A Clinical Analysis of Adult Patients with Autoimmune- and Infection-Associated Hemophagocytic Lymphohistiocytosis
Min W. So¹, Bon S. Koo¹, You J. Kim¹, Yong-G Kim¹, Wook J. Seo², Chang-K Lee¹ and Bin Yoo¹, ¹Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ²Internal Medicine, Seoul Veterans Hospital, Seoul, South Korea
Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially life-threatening disease. Secondary HLH is associated with various clinical conditions, including infections, malignancies, and autoimmune diseases.…

Abstracts tagged "phagocytosis and systemic lupus erythematosus (SLE)"

Intracellular Complement C3 Is Exposed on the Cell Surface upon Apoptosis Induction and Participates in the Clearance of Apoptotic Cells By Phagocytes

Serum Mediated Phagocytosis Of Necrotic Material By Polymorphonuclear Leukocytes May Be Used As a Tool To Predict Clinical Manifestations In Systemic Lupus Erythematosus

Bruton′s Tyrosine Kinase and Calreticulin: A Novel Interaction with Implications for Inflammatory and Autoimmune Disease

A Clinical Analysis of Adult Patients with Autoimmune- and Infection-Associated Hemophagocytic Lymphohistiocytosis