Abstracts tagged "pediatrics and systemic lupus erythematosus (SLE)"

Abstract Number: 458 • ACR/ARHP Annual Meeting 2018
Validation of the 2012 Systemic Lupus International Collaborating Clinics (SLICC) Classification Criteria Compared to the 1997 Acr Criteria and 2017 Candidate Weighted Criteria for Lupus in Pediatric Patients
Meiqian Ma¹, Jane Cerise², B. Anne Eberhard³ and Joyce Hui-Yuen⁴, ¹Pediatric Rheumatology, Cohen Children's Medical Center of New York, Lake Success, NY, ²Biostatistics, The Feinstein Institute for Medical Research, Manhasset, NY, ³Pediatric Rheumatology, Cohen Children's Medical center, Lake Success, NY, ⁴Pediatric Rheumatology, Cohen Children's Medical Center, Lake Success, NY
Background/Purpose: Different classification criteria for systemic lupus erythematosus (SLE) have been proposed over many years. The most widely used and accepted criteria have been the…
Abstract Number: 1271 • ACR/ARHP Annual Meeting 2017
Associations between Systemic Lupus Susceptibility (SLE) Loci and Anti-Phospholipid Antibody (aPL) Positivity in Childhood-Onset SLE (cSLE)
Linda T Hiraki^1,2, France Gagnon³, Earl Silverman², Deborah M. Levy², Sima Abu Alsaoud⁴ and Karl Everett^1,3, ¹Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, ²Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ³Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Genome-wide association studies have identified nearly 60 susceptibility loci for systemic lupus erythematosus (SLE). However, few studies have investigated their influence on specific disease…
Abstract Number: 129 • Pediatric Rheumatology Symposium 2017
Cell-bound Complement Activation Products Correlate with Disease Activity in Childhood-onset Systemic Lupus Erythematosus
Joyce Hui-Yuen¹, Derren Barken², John Conklin³, Tyler O'Malley⁴, Andrew Eichenfield⁵, Amy Starr⁶, Lisa F. Imundo⁷, Thierry Dervieux⁴ and Anca Askanase⁸, ¹Cohen Children's Medical Center of New York, Lake Success, NY, ²Exagen Diagnostics, Vista, CA, ³1261 Liberty Way Suite C, Exagen Diagnostics, Vista, CA, ⁴Research and Development, Exagen Diagnostics, Vista, CA, ⁵Columbia University Medical Center, New York, NY, ⁶Pediatric Rheumatology, Columbia University Medical Center, New York, NY, ⁷Pediatrics, Columbia University Medical Center, New York, NY, ⁸Rheumatology, Columbia University Medical Center, New York, NY
Background/Purpose: Elevated levels of cell-bound complement activation products (C4d deposition on erythrocytes [EC4d] and B lymphocytes [BC4d], CB-CAPs) have been demonstrated to be sensitive and…
Abstract Number: 1398 • ACR/ARHP Annual Meeting 2016
Practice-Based Differences Between Pediatric Rheumatologists and Dermatologists Caring for Children with Discoid Lupus
Lisa Arkin¹, Kaveh Ardalan², Heather Brandling-Bennett³, Yvonne Chiu⁴, Benjamin Chong⁵, Megan Curran⁶, Raegan Hunt⁷, Amy Paller⁸, Victoria P. Werth^9,10, Marisa Klein-Gitelman⁶, Emily von Scheven¹¹ and for the CARRA SLE workgroup, ¹Department of Dermatology and Pediatrics;, University of Wisconsin School of Medicine & Public Health/American Family Children’s Hospital, Madison, WI, ²Division of Rheumatology; Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago/Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Dermatology; Department of Pediatrics, Seattle Children’s Hospital/University of Washington School of Medicine, Seattle, WA, ⁴Department of Dermatology and Pediatrics, Medical College of Wisconsin / Children's Hospital of Wisconsin, Milwaukee, WI, ⁵Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, ⁶Division of Rheumatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago/Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Departments of Dermatology and Pediatrics, Baylor College of Medicine / Texas Children’s Hospital, Houston, TX, ⁸Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine/Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁹Dermatology, University of Pennsylvania, Philadelphia, PA, ¹⁰Dermatology, Veterans Affairs Medical Center, Philadelphia, PA, ¹¹Division of Rheumatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA
Background/Purpose: Discoid lupus erythematosus (DLE) is rare in children. There are no consensus guidelines for management or screening for evolution to systemic lupus erythematosus (SLE).…
Abstract Number: 2420 • ACR/ARHP Annual Meeting 2016
Investigating Genome-Wide Inbreeding Coefficients and Age of Diagnosis in a Multi-Ethnic Population of Childhood-Onset Systemic Lupus Erythematosus (cSLE)
Chen Di Liao¹, Deanna Morra¹, Daniela Dominguez¹, Shazia Ali¹, Deborah M. Levy², Earl Silverman³, Andrew Paterson¹ and Linda T Hiraki¹, ¹The Hospital for Sick Children, Toronto, ON, Canada, ²Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada
Background/Purpose: Genetics plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Up to 20% of those affected with SLE are diagnosed in…
Abstract Number: 2421 • ACR/ARHP Annual Meeting 2016
Cell-Bound Complement Activation Products Correlate with Disease Activity in Childhood-Onset Systemic Lupus Erythematosus
Joyce Hui-Yuen¹, Derren Barken², John Conklin³, Tyler O'Malley⁴, Andrew Eichenfield⁵, Amy Starr⁶, Lisa F. Imundo⁷, Thierry Dervieux⁸ and Anca D. Askanase⁹, ¹North Shore-Long Island Jewish Health System, Lake Success, NY, ²Exagen Diagnostics, Inc., Vista, CA, ³1261 Liberty Way Suite C, Exagen Diagnostics, Vista, CA, ⁴Research and Development, Exagen Diagnostics, Vista, CA, ⁵Morgan Stanley Children's Hospital of NY-Presbyterian, Columbia University, New York, NY, ⁶Pediatric Rheumatology, Columbia University Medical Center, New York, NY, ⁷Assoociate Professor of Pediatrics in Medicine - Rheumatology, Columbia University Medical Center, New York, NY, ⁸Research and Development, Exagen Diagnostics, Inc., Vista, CA, ⁹Department of Medicine, Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY
Background/Purpose: Elevated levels of cell-bound complement activation products (C4d deposition on erythrocytes [EC4d] and B lymphocytes [BC4d], CB-CAPs) have been demonstrated to be sensitive and…
Abstract Number: 2665 • ACR/ARHP Annual Meeting 2014
Risk of Hydrocephalus and/or Macrocephaly in Children Born to Mothers with SLE
Catherine Huang¹, Sasha Bernatsky², Christian A. Pineau³, Susan Scott⁴, Ann E. Clarke⁵, Robert W. Platt¹ and Evelyne Vinet⁶, ¹McGill University, Montreal, QC, Canada, ²Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ³Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ⁴McGill University Health Centre, Montreal, QC, Canada, ⁵Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ⁶McGill University Health Center, Montreal, QC, Canada
Background/Purpose Evidence suggests that both hydrocephalus and macrocephaly could be potential manifestations of neonatal lupus. In a recent study of 87 children born to mothers…
Abstract Number: 2664 • ACR/ARHP Annual Meeting 2014
Increased Risk of Hematological Malignancies in Children Born to Women with SLE
Evelyne Vinet¹, Ann E. Clarke², Christian A. Pineau³, Susan Scott⁴, Robert W. Platt⁵ and Sasha Bernatsky⁶, ¹McGill University Health Center, Montreal, QC, Canada, ²Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ³Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ⁴McGill University Health Centre, Montreal, QC, Canada, ⁵McGill University, Montreal, QC, Canada, ⁶Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose Patients with SLE have an increased risk of hematological malignancies, particularly non-Hodgkin lymphoma, compared to the general population. Recently, in utero exposures, such as…
Abstract Number: 1698 • ACR/ARHP Annual Meeting 2013
Sex-Related Differences and Trends In Mortality Of Juvenile-Onset Systemic Lupus Erythematosus (SLE) In The United States Over The Last Forty Years, 1971-2010
Eric Y. Yen¹, Jennifer M.P. Woo² and Deborah K. McCurdy³, ¹Pediatrics/Rheumatology, UCLA Division of Pediatric Rheumatology, Los Angeles, CA, ²Pediatric Rheumatology, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA, ³Pediatric Rheumatology, UCLA Division of Pediatric Rheumatology, Los Angeles, CA
Background/Purpose: To date, SLE-specific mortality studies in children and adolescents are few. Estimations of mortality in adult cohorts of SLE patients have shown that male…
Abstract Number: 1268 • ACR/ARHP Annual Meeting 2013
Long-Term Follow-Up Of a Pediatric Lupus Cohort: Transition Of Care and Health Related Outcomes
Susanna Felsenstein¹, Anusha Ramanathan², Beatriz Gonzalez³ and Andreas Reiff⁴, ¹Pediatric Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA, ²Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA, ³Pediatric Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA, ⁴Division of Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA
Background/Purpose: Transition from pediatric to adult care is a difficult process with the potential for negative impact on medical, psychological and social outcomes. In this…
Abstract Number: 2262 • ACR/ARHP Annual Meeting 2012
Hypogammaglobulinemia in Pediatric Systemic Lupus Erythematosus
Emilina Lim¹ and Megan A. Cooper², ¹Pediatric Rheumatology, Washington University in Saint Louis- St. Louis Children's Hospital, St. Louis, MO, ²Pediatrics, Washington University School of Medicine, St. Louis, MO
Background/Purpose: : Systemic lupus erythematosus (SLE) is characterized by B cell activation, elevated serum IgG and prominent circulating immune complexes. However, hypogammaglobulinemia in SLE patients…
Abstract Number: 302 • ACR/ARHP Annual Meeting 2012
Accuracy of Systemic Lupus International Collaborating Clinics Classiffication Criteria Applied to Juvenile Systemic Lupus Erythematosus Patients
Marìa M. Katsicas¹, Ezequiel Borgia², Ileana Villarroel² and Ricardo Russo³, ¹Service of Immunology & Rheumatology. Hospital de Pediatrìa Prof Dr.Juan.P. Garrahan, MD, Buenos Aires, Argentina, ²Service of Immunology & Rheumatology. Hospital de Pediatrìa Prof Dr.Juan.P. Garrahan, MD, Caba, Argentina, ³Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genova, Italy
Background/Purpose: Systemic lupus erythematosus (SLE) is a prototype autoimmune disease. The most widely used classification criteria for SLE were those developed by the American College…