ACR Meeting Abstracts

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Abstracts tagged "pediatrics and systemic lupus erythematosus (SLE)"

  • Abstract Number: 458 • 2018 ACR/ARHP Annual Meeting

    Validation of the 2012 Systemic Lupus International Collaborating Clinics (SLICC) Classification Criteria Compared to the 1997 Acr Criteria and 2017 Candidate Weighted Criteria for Lupus in Pediatric Patients

    Meiqian Ma1, Jane Cerise2, B. Anne Eberhard3 and Joyce Hui-Yuen4, 1Pediatric Rheumatology, Cohen Children's Medical Center of New York, Lake Success, NY, 2Biostatistics, The Feinstein Institute for Medical Research, Manhasset, NY, 3Pediatric Rheumatology, Cohen Children's Medical center, Lake Success, NY, 4Pediatric Rheumatology, Cohen Children's Medical Center, Lake Success, NY

    Background/Purpose: Different classification criteria for systemic lupus erythematosus (SLE) have been proposed over many years. The most widely used and accepted criteria have been the…
  • Abstract Number: 1271 • 2017 ACR/ARHP Annual Meeting

    Associations between Systemic Lupus Susceptibility (SLE) Loci and Anti-Phospholipid Antibody (aPL) Positivity in Childhood-Onset SLE (cSLE)

    Linda T Hiraki1,2, France Gagnon3, Earl Silverman2, Deborah M. Levy2, Sima Abu Alsaoud4 and Karl Everett1,3, 1Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, 2Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 3Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, 4Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose: Genome-wide association studies have identified nearly 60 susceptibility loci for systemic lupus erythematosus (SLE). However, few studies have investigated their influence on specific disease…
  • Abstract Number: 129 • 2017 Pediatric Rheumatology Symposium

    Cell-bound Complement Activation Products Correlate with Disease Activity in Childhood-onset Systemic Lupus Erythematosus

    Joyce Hui-Yuen1, Derren Barken2, John Conklin3, Tyler O'Malley4, Andrew Eichenfield5, Amy Starr6, Lisa F. Imundo7, Thierry Dervieux4 and Anca Askanase8, 1Cohen Children's Medical Center of New York, Lake Success, NY, 2Exagen Diagnostics, Vista, CA, 31261 Liberty Way Suite C, Exagen Diagnostics, Vista, CA, 4Research and Development, Exagen Diagnostics, Vista, CA, 5Columbia University Medical Center, New York, NY, 6Pediatric Rheumatology, Columbia University Medical Center, New York, NY, 7Pediatrics, Columbia University Medical Center, New York, NY, 8Rheumatology, Columbia University Medical Center, New York, NY

    Background/Purpose: Elevated levels of cell-bound complement activation products (C4d deposition on erythrocytes [EC4d] and B lymphocytes [BC4d], CB-CAPs) have been demonstrated to be sensitive and…
  • Abstract Number: 1398 • 2016 ACR/ARHP Annual Meeting

    Practice-Based Differences Between Pediatric Rheumatologists and Dermatologists Caring for Children with Discoid Lupus

    Lisa Arkin1, Kaveh Ardalan2, Heather Brandling-Bennett3, Yvonne Chiu4, Benjamin Chong5, Megan Curran6, Raegan Hunt7, Amy Paller8, Victoria P. Werth9,10, Marisa Klein-Gitelman6, Emily von Scheven11 and for the CARRA SLE workgroup, 1Department of Dermatology and Pediatrics;, University of Wisconsin School of Medicine & Public Health/American Family Children’s Hospital, Madison, WI, 2Division of Rheumatology; Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago/Northwestern University Feinberg School of Medicine, Chicago, IL, 3Division of Dermatology; Department of Pediatrics, Seattle Children’s Hospital/University of Washington School of Medicine, Seattle, WA, 4Department of Dermatology and Pediatrics, Medical College of Wisconsin / Children's Hospital of Wisconsin, Milwaukee, WI, 5Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, 6Division of Rheumatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago/Northwestern University Feinberg School of Medicine, Chicago, IL, 7Departments of Dermatology and Pediatrics, Baylor College of Medicine / Texas Children’s Hospital, Houston, TX, 8Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine/Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 9Dermatology, University of Pennsylvania, Philadelphia, PA, 10Dermatology, Veterans Affairs Medical Center, Philadelphia, PA, 11Division of Rheumatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Discoid lupus erythematosus (DLE) is rare in children.  There are no consensus guidelines for management or screening for evolution to systemic lupus erythematosus (SLE).…
  • Abstract Number: 2420 • 2016 ACR/ARHP Annual Meeting

    Investigating Genome-Wide Inbreeding Coefficients and Age of Diagnosis in a Multi-Ethnic Population of Childhood-Onset Systemic Lupus Erythematosus (cSLE)

    Chen Di Liao1, Deanna Morra1, Daniela Dominguez1, Shazia Ali1, Deborah M. Levy2, Earl Silverman3, Andrew Paterson1 and Linda T Hiraki1, 1The Hospital for Sick Children, Toronto, ON, Canada, 2Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 3University of Toronto, Toronto, ON, Canada

    Background/Purpose: Genetics plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Up to 20% of those affected with SLE are diagnosed in…
  • Abstract Number: 2421 • 2016 ACR/ARHP Annual Meeting

    Cell-Bound Complement Activation Products Correlate with Disease Activity in Childhood-Onset Systemic Lupus Erythematosus

    Joyce Hui-Yuen1, Derren Barken2, John Conklin3, Tyler O'Malley4, Andrew Eichenfield5, Amy Starr6, Lisa F. Imundo7, Thierry Dervieux8 and Anca D. Askanase9, 1North Shore-Long Island Jewish Health System, Lake Success, NY, 2Exagen Diagnostics, Inc., Vista, CA, 31261 Liberty Way Suite C, Exagen Diagnostics, Vista, CA, 4Research and Development, Exagen Diagnostics, Vista, CA, 5Morgan Stanley Children's Hospital of NY-Presbyterian, Columbia University, New York, NY, 6Pediatric Rheumatology, Columbia University Medical Center, New York, NY, 7Assoociate Professor of Pediatrics in Medicine - Rheumatology, Columbia University Medical Center, New York, NY, 8Research and Development, Exagen Diagnostics, Inc., Vista, CA, 9Department of Medicine, Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY

    Background/Purpose: Elevated levels of cell-bound complement activation products (C4d deposition on erythrocytes [EC4d] and B lymphocytes [BC4d], CB-CAPs) have been demonstrated to be sensitive and…
  • Abstract Number: 2665 • 2014 ACR/ARHP Annual Meeting

    Risk of Hydrocephalus and/or Macrocephaly in Children Born to Mothers with SLE

    Catherine Huang1, Sasha Bernatsky2, Christian A. Pineau3, Susan Scott4, Ann E. Clarke5, Robert W. Platt1 and Evelyne Vinet6, 1McGill University, Montreal, QC, Canada, 2Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, 3Rheumatology, McGill University Health Centre, Montreal, QC, Canada, 4McGill University Health Centre, Montreal, QC, Canada, 5Division of Rheumatology, University of Calgary, Calgary, AB, Canada, 6McGill University Health Center, Montreal, QC, Canada

    Background/Purpose Evidence suggests that both hydrocephalus and macrocephaly could be potential manifestations of neonatal lupus. In a recent study of 87 children born to mothers…
  • Abstract Number: 2664 • 2014 ACR/ARHP Annual Meeting

    Increased Risk of Hematological Malignancies in Children Born to Women with SLE

    Evelyne Vinet1, Ann E. Clarke2, Christian A. Pineau3, Susan Scott4, Robert W. Platt5 and Sasha Bernatsky6, 1McGill University Health Center, Montreal, QC, Canada, 2Division of Rheumatology, University of Calgary, Calgary, AB, Canada, 3Rheumatology, McGill University Health Centre, Montreal, QC, Canada, 4McGill University Health Centre, Montreal, QC, Canada, 5McGill University, Montreal, QC, Canada, 6Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose Patients with SLE have an increased risk of hematological malignancies, particularly non-Hodgkin lymphoma, compared to the general population. Recently, in utero exposures, such as…
  • Abstract Number: 1698 • 2013 ACR/ARHP Annual Meeting

    Sex-Related Differences and Trends In Mortality Of Juvenile-Onset Systemic Lupus Erythematosus (SLE) In The United States Over The Last Forty Years, 1971-2010

    Eric Y. Yen1, Jennifer M.P. Woo2 and Deborah K. McCurdy3, 1Pediatrics/Rheumatology, UCLA Division of Pediatric Rheumatology, Los Angeles, CA, 2Pediatric Rheumatology, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA, 3Pediatric Rheumatology, UCLA Division of Pediatric Rheumatology, Los Angeles, CA

    Background/Purpose:  To date, SLE-specific mortality studies in children and adolescents are few.  Estimations of mortality in adult cohorts of SLE patients have shown that male…
  • Abstract Number: 1268 • 2013 ACR/ARHP Annual Meeting

    Long-Term Follow-Up Of a Pediatric Lupus Cohort: Transition Of Care and Health Related Outcomes

    Susanna Felsenstein1, Anusha Ramanathan2, Beatriz Gonzalez3 and Andreas Reiff4, 1Pediatric Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA, 2Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA, 3Pediatric Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA, 4Division of Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA

    Background/Purpose: Transition from pediatric to adult care is a difficult process with the potential for negative impact on medical, psychological and social outcomes.  In this…
  • Abstract Number: 2262 • 2012 ACR/ARHP Annual Meeting

    Hypogammaglobulinemia in Pediatric Systemic Lupus Erythematosus

    Emilina Lim1 and Megan A. Cooper2, 1Pediatric Rheumatology, Washington University in Saint Louis- St. Louis Children's Hospital, St. Louis, MO, 2Pediatrics, Washington University School of Medicine, St. Louis, MO

    Background/Purpose: : Systemic lupus erythematosus (SLE) is characterized by B cell activation, elevated serum IgG and prominent circulating immune complexes. However, hypogammaglobulinemia in SLE patients…
  • Abstract Number: 302 • 2012 ACR/ARHP Annual Meeting

    Accuracy of Systemic Lupus International Collaborating Clinics Classiffication Criteria Applied to Juvenile Systemic Lupus Erythematosus Patients

    Marìa M. Katsicas1, Ezequiel Borgia2, Ileana Villarroel2 and Ricardo Russo3, 1Service of Immunology & Rheumatology. Hospital de Pediatrìa Prof Dr.Juan.P. Garrahan, MD, Buenos Aires, Argentina, 2Service of Immunology & Rheumatology. Hospital de Pediatrìa Prof Dr.Juan.P. Garrahan, MD, Caba, Argentina, 3Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genova, Italy

    Background/Purpose: Systemic lupus erythematosus (SLE) is a prototype autoimmune disease. The most widely used classification criteria for SLE were those developed by the American College…
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