Abstracts tagged "Pediatric rheumatology and systemic lupus erythematosus (SLE)"

Abstract Number: 400 • 2015 ACR/ARHP Annual Meeting
Disease Activity and Health Care Utilization Among Young Adults with Childhood-Onset Lupus Transitioning to Adult Care: Data from the Pediatric Lupus Outcomes Study
Erica F. Lawson¹ and Aimee O. Hersh², ¹Pediatrics/Rheumatology, UC San Francisco, San Francisco, CA, ²Pediatrics/Rheumatology, University of Utah, Salt Lake City, UT
Background/Purpose: Individuals with childhood-onset systemic lupus erythematosus (cSLE) must transfer from pediatric- to adult-oriented health care as they enter adulthood. However, few studies have assessed…
Abstract Number: 2043 • 2015 ACR/ARHP Annual Meeting
Cell-Bound Complement Activation Products Have High Sensitivity and Specificity in Childhood-Onset Systemic Lupus Erythematosus and Juvenile Idiopathic Arthritis
Anca Askanase¹, Joyce Hui-Yuen², John Conklin³, Derren Barken⁴, Tyler O'Malley⁵, Xiao Qing Li⁶, Liza Mariel Bermudez², Andrew Eichenfield⁷, Amy J. Starr⁸, Lisa F. Imundo^9,10 and Thierry Dervieux¹¹, ¹Columbia University College of Physicians & Surgeons, New York, NY, ²Pediatric Rheumatology, Columbia University Medical Center, New York, NY, ³1261 Liberty Way Suite C, Exagen Diagnostics, Vista, CA, ⁴Exagen Diagnostics, Inc., Vista, CA, ⁵Research and Development, Exagen Diagnostics, Vista, CA, ⁶Adult Rheumatology, Columbia University Medical Center, New York, NY, ⁷Morgan Stanley Children's Hospital of NY-Presbyterian, Columbia University, New York, NY, ⁸Columbia University Medical Center, New York, NY, ⁹Assoociate Professor of Pediatrics in Medicine - Rheumatology, Columbia University Medical Center, New York, NY, ¹⁰New York Presbyterian Hospitsl, Columbia University, New York, NY, ¹¹Research and Development, Exagen Diagnostics, Inc., Vista, CA
Background/Purpose: Elevated levels of cell-bound complement activation products (C4d deposition on erythrocytes [EC4d] and B lymphocytes [BC4d], CBCAPS) have been demonstrated to be sensitive and…
Abstract Number: 1299 • 2014 ACR/ARHP Annual Meeting
A Cross-Sectional Study of Mental Health Symptoms and Mental Health Care in Pediatric SLE/MCTD Patients and Their Peers
Andrea Knight^1,2, Michelle Vickery¹, Pamela Weiss^1,2,3, Knashawn Morales³ and Ron Keren^3,4, ¹Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, ²Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ³Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, ⁴Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Mental health problems are prevalent in pediatric systemic lupus erythematosus (SLE). We aimed to compare the rates of mental health problems and mental health…
Abstract Number: 1296 • 2014 ACR/ARHP Annual Meeting
Pulse- Pediatric Update on Lupus in South Africa: Epidemiology and Management
Laura Lewandowski¹, Laura Schanberg¹, Nathan Thielman² and Christiaan Scott³, ¹Pediatric Rheumatology, Duke University Medical Center, Durham, NC, ²Duke Hubert Yeargan Center for Global Health, Durham, NC, ³Rheumatology, Red Cross War Memorial Children's Hospital, Cape Town, South Africa
Background/Purpose: In developed nations, SLE is more common and severe in people of African extraction than in Caucasians; however, the epidemiology of SLE in Africa…
Abstract Number: 1295 • 2014 ACR/ARHP Annual Meeting
Childhood-Onset Systemic Lupus Erythematosus: Short-Term Treatment Response Rates in Proliferative Lupus Nephritis
Andrea Human¹, Simon Yu Tian², Earl D. Silverman³ and Deborah M. Levy¹, ¹Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ²Rheumatology and Program of Child Health Evaluative Sciences, The Hospital for Sick Children, Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Proliferative Lupus Nephritis (PLN) occurs in up to 50% of patients with childhood-onset systemic lupus erythematosus (cSLE). PLN is a significant source of morbidity and…
Abstract Number: 672 • 2014 ACR/ARHP Annual Meeting
Favorable Response to Belimumab in Pediatric-Onset Systemic Lupus Erythematosus
Joyce Hui-Yuen¹, Jennifer Taylor², Xiao Qing Li³, Liza Mariel Bermudez¹, Josephine Isgro¹, Andrew H. Eichenfield⁴, Amy J. Starr⁴, Lisa F. Imundo⁵, Jill P. Buyon⁶, Richard Furie⁷, Diane L. Kamen⁸, Susan Manzi⁹, Michelle Petri¹⁰, Rosalind Ramsey-Goldman¹¹, Ronald van Vollenhoven¹², Daniel J. Wallace¹³ and Anca Askanase⁴, ¹Pediatric Rheumatology, Columbia University Medical Center, New York, NY, ²Pediatrics, Columbia University Medical Center, New York, NY, ³Adult Rheumatology, Columbia University Medical Center, New York, NY, ⁴Columbia University Medical Center, New York, NY, ⁵Assoociate Professor of Pediatrics in Medicine - Rheumatoology, Columbia University Medical Center, New York, NY, ⁶Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁷Division of Rheumatology, North Shore-LIJ Health System, Great Neck, NY, ⁸Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁹Division of Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ¹⁰Johns Hopkins University School of Medicine, Baltimore, MD, ¹¹Rheumatology, Northwestern University and Feinberg School of Medicine, Chicago, IL, ¹²Karolinska Institute, Stockholm, Sweden, ¹³Cedars-Sinai Medical Center, Los Angeles, CA
Background/Purpose: Belimumab (Benlysta) is a human monoclonal antibody that inhibits soluble B-lymphocyte stimulator. It was approved by the FDA in 2011 for treatment of active,…
Abstract Number: 10 • 2014 ACR/ARHP Annual Meeting
Antiphospholipid Antibodies and Neuropsychiatric Events in Pediatric Patients
Mileka Gilbert¹ and Lenore M. Buckley², ¹Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, ²Section of Rheumatology, Yale School of Medicine, New Haven, CT
Background/Purpose: An association between anti-phospholipid antibodies (aPL abs) and non-thrombotic neuropsychiatric events has been reported in pediatric and adult patients, including patients who do not…
Abstract Number: 1785 • 2013 ACR/ARHP Annual Meeting
Structural Determinants Of Low Vertebral Strength In Pediatric Systemic Lupus Erythematosus
Jon M. Burnham¹, Babette S. Zemel¹, David C. Lee², Tony M. Keaveny³ and Mary Beth Leonard¹, ¹Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ²O.N. Diagnostics, LLC, Berkeley, CA, ³Founder and Chief Science Officer, University of California, Berkeley, CA and O.N. Diagnostics, LLC, Berkeley, CA
Background/Purpose: Children with systemic lupus erythematosus (SLE) are at high risk for bone fragility. Studies in pediatric SLE using two-dimensional lumbar spine (LS) dual X-ray…
Abstract Number: 1716 • 2013 ACR/ARHP Annual Meeting
Childhood-Onset Systemic Lupus Erythematosus With Clinical Neurocognitive Dysfunction Have Lower Nodal Density and Connectivity On Diffusion Tensor Imaging
Jordan T. Jones¹, Mark DiFrancesco², Ahmad I. Zaal¹, Marisa S. Klein-Gitelman³, Darren Gitelman⁴, Jun Ying⁵ and Hermine Brunner¹, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Division of Rheumatology, Children's Memorial Hospital, Chicago, IL, ⁴Neurology, Northwestern University, Chicago, IL, ⁵Medicine-Internal Medicine-General Medicine, University of Cincinnati, Cincinnati, OH
Background/Purpose: Neurocognitive dysfunction (NCD) is common in childhood-onset systemic lupus erythematosus (cSLE), and often difficult to detect with current resources. Diffusion tensor imaging (DTI) is…
Abstract Number: 1615 • 2013 ACR/ARHP Annual Meeting
Type I Interferons As a Serum Biomarker Of Subclinical Atherosclerosis In Pediatric Systemic Lupus Erythematosus Patients
Smriti Mohan¹, Julie Barsalou², Timothy J. Bradley³, Cameron Slorach³, Lawrence Ng⁴, Deborah M. Levy⁵, Earl D. Silverman² and Mariana J. Kaplan⁶, ¹Pediatric Rheumatology, University of Michigan, Ann Arbor, MI, ²Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ³Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁵Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ⁶Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder with a marked increase in cardiovascular (CV) morbidity and mortality due to premature atherosclerosis, distinct…
Abstract Number: 1257 • 2013 ACR/ARHP Annual Meeting
Feasibility and Clinical Implications Of The Pediatric Automated Neuropsychological Assessment Metrics for Screening Of Childhood-Onset Neuropsychiatric Systemic Lupus Erythematosus
Patricia Vega-Fernandez¹, Natasha M. Ruth², Deborah M. Levy³, Frank Zelko⁴, Eyal Muscal⁵, Marisa S. Klein-Gitelman⁶, HaiMei Liu⁷, Adam Huber⁸, Jiha Lee⁹, Jessica Hummel⁹, Lori B. Tucker¹⁰, Tresa Roebuck-Spencer¹¹ and Hermine Brunner^12,13, ¹Division of Rheumatology, Cincinanti Children's Hospital Medical Center, Cincinnati, OH, ²Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, ³Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ⁴Pediatric Neuropsychology Service, Children's Memorial Hospital, Chicago, IL, ⁵TCH Pediatric Rheum Center, Baylor College of Medicine, Houston, TX, ⁶Division of Rheumatology, Children's Memorial Hospital, Chicago, IL, ⁷Children's Hospital of Fundan University, Shanghai, China, ⁸IWK Health Centre, Halifax, NS, Canada, ⁹Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁰Rheumatology, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, ¹¹Cognitive Science Research Center, University of Oklahoma, Norman, OK, ¹²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹³Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Neuropsychiatric disease is common in childhood-onset Systemic Lupus Erythematosus (cSLE). Signs of cNPSLE can be subtle and difficult to ascertain in daily clinical practice.…
Abstract Number: 1263 • 2013 ACR/ARHP Annual Meeting
Childhood-Onset Systemic Lupus Erythematosus In Ontario: Long Term Outcomes In a Population-Based Cohort With Universal Health Care Coverage
Deborah M. Levy¹, Nadia Gunraj², Janet E. Pope³, J. Carter Thorne⁴, Wesley Fidler⁵, Peter B. Dent⁶, Johannes Roth⁷, Roberta A. Berard⁸, Murray Berall⁹, Astrid Guttmann¹⁰ and Earl D. Silverman¹¹, ¹Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ²Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, ³Medicine/Rheumatology, St. Joseph's Health Care, University of Western Ontario, London, ON, Canada, ⁴Southlake Regional Health Centre, Newmarket, ON, Canada, ⁵Rheumatology, St. Joseph's Hospital, Thunder Bay, ON, Canada, ⁶McMaster University, Hamilton, ON, Canada, ⁷University of Ottawa, Ottawa, ON, Canada, ⁸Children's Hospital of Western Ontario, London, ON, Canada, ⁹Nephrology, Humber River Regional Hospital, Toronto, ON, Canada, ¹⁰Pediatrics, Institute for Clinical Evaluative Sciences, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ¹¹Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Background/Purpose: Little is known about the long-term morbidity and mortality of childhood-onset SLE (cSLE) after transition to adult care; however, linking clinical data to administrative…
Abstract Number: 1264 • 2013 ACR/ARHP Annual Meeting
Evaluation Of Quality Indicators and Disease Damage In Childhood-Onset Systemic Lupus Erythematosus Patients
Julia G. Harris^1,2, Kristyn I. Maletta³, Evelyn M. Kuhn³ and Judyann C. Olson^1,2, ¹Medical College of Wisconsin, Milwaukee, WI, ²Children's Hospital of Wisconsin, Milwaukee, WI, ³National Outcomes Center, Children's Hospital of Wisconsin, Milwaukee, WI
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect virtually every organ system and may lead to significant morbidities. A…
Abstract Number: 1267 • 2013 ACR/ARHP Annual Meeting
Impact Of Disease Duration On Vascular Surrogates Of Early Atherosclerosis In Childhood-Onset Systemic Lupus Erythematosus
Julie Barsalou¹, Timothy J. Bradley², Cameron Slorach², Lawrence W.K. Ng³, Deborah M. Levy⁴ and Earl D. Silverman¹, ¹Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ²Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ³Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
Background/Purpose: Cardiovascular disease is a leading cause of morbidity and mortality in adults with systemic lupus erythematosus. Exposure to atherogenic risk factors in childhood-onset SLE…
Abstract Number: 1270 • 2013 ACR/ARHP Annual Meeting
Risk Factors For The Development Of Avascular Necrosis In Pediatric Systemic Lupus Erythematosus Patients
Reut Gurion¹, Howard Yang², Hong Li³, Stephanie Frenkian², Kathleen A. Haines⁴, Jennifer E. Weiss⁵, Yukiko Kimura⁵, Andrew S. Zeft⁶, Angela B. Robinson⁷, Suzanne C. Li⁸ and for The CARRA Registry Investigators⁹, ¹Pediatric Infectious Diseases, Rheumatology, and Geographic Medicine, Rainbow Babies and Children's Hospital / Case Medical Center, Cleveland, OH, ²Joseph M Sanzari Children’s Hospital, Hackensack University Medical Center, Hackensack, NJ, ³Case Western Reserve University, Cleveland, OH, ⁴Department of Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack University Medical Center, Hackensack, NJ, ⁵Pediatric Rheumatology, Joseph M Sanzari Children’s Hospital, Hackensack University Medical Center, Hackensack, NJ, ⁶Pediatric Institute, Department of Pediatric Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, ⁷Pediatric Infectious Disease, Rheumatology and Geographic Medicine, Rainbow Babies and Children's Hospital / Case Medical Center, Cleveland, OH, ⁸Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack University Medical Center, Hackensack, NJ, ⁹Duke Clinical Research Institute, Durham, NC
Background/Purpose: Avascular necrosis (AVN) is a serious morbidity of pediatric systemic lupus erythematosus (pSLE) associated with disability, impaired quality of life, and increased cost of…

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