Abstracts tagged "Pathophysiology and systemic lupus erythematosus (SLE)"

Abstract Number: 2723 • ACR/ARHP Annual Meeting 2013
Role Of Interferon-Inducible RNA-Dependent Protein Kinase In The Pathogenesis Of Systemic Lupus Erythematosus
Aurélie De Groof¹, Benoît Van den Eynde², Frédéric A. Houssiau³ and Bernard Lauwerys¹, ¹Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ²Institut de Duve, Université catholique de Louvain, Brussels, Belgium, ³Institut de Recherche Expérimentale et Clinique, Pôle de Maladies Rhumatismales, Université catholique de Louvain, Brussels, Belgium
Background/Purpose: PRKR (interferon-inducible RNA-dependent protein kinase) is an intracytoplasmic molecule that induces the production of interferon(IFN)-induced genes upon binding of double-stranded RNA viruses. PRKR is…