Abstracts tagged "pathogenesis"

Abstract Number: 2711 • 2015 ACR/ARHP Annual Meeting
The Lung Microbiome in Rheumatoid Arthritis and Associated Local/Systemic Autoimmunity
Jose U. Scher¹, Vijay Joshua², Carles Ubeda³, Alejandro Artacho³, Leopoldo Segal⁴ and Anca I Catrina⁵, ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Cmm L8:04, Karolinska Institutet, Stockholm, Sweden, ³Institute for Research in Public Health, Valencia, Spain, ⁴Medicine, Pulmonay Division, NYU School of Medicine, New York City, NY, ⁵Department of Medicine, Solna, Unit of Rheumatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is a complex autoimmune disorder in which several genetic and environmental factors play a role. Recent data suggest that the gut…
Abstract Number: 483 • 2015 ACR/ARHP Annual Meeting
Antibody to Malondialdehyde-Acetaldehyde (MAA) Adducts Serve As Biomarkers of Treatment Response in Rheumatoid Arthritis
Ted R. Mikuls¹, Brian Coburn¹, Harlan Sayles², Fang Yu³, Mary Brophy⁴, James R. O'Dell¹, Lynell W. Klassen⁵ and Geoffrey M. Thiele¹, ¹Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ²University of Nebraska Medical Center, Omaha, NE, ³Public Health, University of Nebraska Medical Center, Omaha, NE, ⁴VA Boston Heathcare System, Boston, MA, ⁵Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Previous reports have demonstrated that malondialdehyde-acetaldehyde (MAA) adducts are produced as a byproduct of oxidative stress and lipid peroxidation and are expressed in…
Abstract Number: 2723 • 2015 ACR/ARHP Annual Meeting
Basal STAT5 Signaling Is Elevated in Multiple Peripheral Blood Cell Subsets in Rheumatoid Arthritis and Is Markedly Downregulated By IFN-Î³ in T Lymphocytes
Molly Boland¹, Yanna Ding², Surabhi Vinod³, S. Louis Bridges Jr.⁴ and Chander Raman¹, ¹Medicine/Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Medicine/Division of Clinical Immunology and Rheumatology, University of Alabama Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The importance of type I interferons (IFN-α and others) as a driver of pathogenesis in autoimmunity, including rheumatoid arthritis (RA) is well recognized. However,…
Abstract Number: 519 • 2015 ACR/ARHP Annual Meeting
In Indigenous North Americans at High Risk for RA Complement C5 Level Is Associated with ACPA Positivity and C5a with Transition to Synovitis Even after Correcting for in Vitro Complement Activation Found with Prolonged Sample Storage
Ceri Richards¹, Carol Hitchon², Xiaobo Meng³, Irene Smolik⁴, David Robinson⁴ and Hani S. El-Gabalawy⁴, ¹Internal Medicine, University of Manitoba, Winnipeg, MB, Canada, ²Department of Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ³University of Manitoba, Winnipeg, MB, Canada, ⁴Arthritis Center, University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Complement activation, a key component of innate immunity and activator of adaptive immunity has been linked to RA pathogenesis. Anti-citrullinated peptide antibody (ACPA) and…
Abstract Number: 3085 • 2015 ACR/ARHP Annual Meeting
Platelet Activation and Endothelial Reactivity in the Pathogenesis of Tissue Inflammation/Injury in Systemic Lupus Erythematosus
Robert Clancy¹, Sokha Nhek², Jonathan Newman³, Janet Nwaukoni¹, Sara Rasmussen⁴, Jill P. Buyon¹, Maya Rubin⁵, Kristen Lee¹ and Jeffrey Berger⁵, ¹Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²New York University School of Medicine, New York, NY, ³Medicine, New York University School of Medicine, New York, NY, ⁴Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁵Medicine, Division of Cardiology, New York University School of Medicine, New York, NY
Background/Purpose: Patients with systemic lupus erythematosus (SLE) are at increased risk for widespread endothelial dysfunction, vascular thromboses, and premature cardiovascular disease. Enhanced platelet activation and…
Abstract Number: 535 • 2015 ACR/ARHP Annual Meeting
Taurine As a Biomarker for Prediction of Response to Biologic Therapy in Rheumatoid Arthritis
Soshi Takahashi¹, Jun Saegusa², Ikuko Naka¹, Kosaku Tsuda¹, Takaichi Okano¹, Kengo Akashi¹, Miwa Nishida¹, Keisuke Nishimura², Sho Sendo², Yo Ueda¹, Akira Onishi³, Yoshinori Kogata², Goichi Kageyama² and Akio Morinobu², ¹Department of Rheumatology, Kobe University Hospital, Kobe, Japan, ²Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Rheumaology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: To identify a serum biomarker for prediction of the response to biologics (Bio) in patients with rheumatoid arthritis (RA), we performed serum metabolomics analysis…
Abstract Number: 3098 • 2015 ACR/ARHP Annual Meeting
Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease at 12 Months: Results from the Pathobiology of Early Arthritis Cohort
Maria DiCicco¹, Frances Humby¹, Stephen Kelly², Rebecca Hands¹, nora ng³, Arti Mahto³, Illias Lazarou³, Vidalba Rocher¹, Lu Zou³, Michele Bombardieri⁴, Christopher Buckley⁵, A.H.M. van der Helm- van Mil⁶, Robert B.M. Landewé⁷, Désirée van der Heijde⁸, Iain B. McInnes⁹, Peter C. Taylor¹⁰ and Costantino Pitzalis¹¹, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ²William Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, ³William Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, London, United Kingdom, ⁴Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, ⁵University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom, ⁶Leiden University Medical Center, Leiden, Netherlands, ⁷University of Amsterdam and Atrium Medical Center, Amsterdam, Netherlands, ⁸Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁹Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ¹⁰Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford Botnar Research Centre, Oxford, United Kingdom, ¹¹Centre for Experimental Medicine & Rheumatology, Queen Mary's School of Medicine and Dentistry, London, United Kingdom
Background/Purpose: The inflammatory cell infiltrate in RA synovium has been recognised to organise into lymphocytic aggregates (Ags) with data to suggest that these structures are…
Abstract Number: 2447 • 2014 ACR/ARHP Annual Meeting
The Role of TET3-Mediated DNA Demethylation By Pro-Inflammatory Cytokines in Rheumatoid Arthritis
Kazuhisa Nakano¹, Kunihiro Yamaoka¹, Akira Kurozumi², Akio Kawabe², Kaoru Yamagata² and Yoshiya Tanaka³, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The first department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose In the pathogenesis of Rheumatoid arthritis (RA) RA fibroblast-like synoviocytes (RA FLS) exhibit a unique aggressive phenotype that contributes to the cytokine milieu and…
Abstract Number: 2448 • 2014 ACR/ARHP Annual Meeting
DNA Methylation Analysis of Lymph Node Stromal Cells of Rheumatoid Arthritis Patients
Emmanuel Karouzakis¹, Caroline Ospelt¹, Janine Hähnlein², Renate E. Gay³, Paul Peter Tak⁴, Danielle Marie Gerlag⁵, Michel Neidhart¹, Steffen Gay¹ and Lisa G.M. van Baarsen², ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁴University of Cambridge,Cambridge and GlaxoSmithKline, Stevenage, United Kingdom, ⁵GSK,Clinical Unit Cambridge,R&D Projects Clinical Platforms & Sciences, Cambridge, United Kingdom
Background/Purpose Lymph node stromal cells (LNSC) build the scaffold that enables migration and interaction of lymphocytes in the lymph node. More recently, it has been…
Abstract Number: 2449 • 2014 ACR/ARHP Annual Meeting
Microrna-346 Regulation of Follicular Helper T Cells Is Involved in the Pathogenesis of rheumatoid Arthritis Disease
Xinyi Tang¹, Jie Ma² and Shengjun Wang³, ¹Department of Laboratory Medicine, Jiangsu University Affi�liated People’s Hospital, Zhenjiang, China, ²Department of Laboratory Medicine, Jiangsu University Afﬁliated People’s Hospital, Zhenjiang, China, ³Department of Laboratory Medicine, Jiangsu University Affiliated People’s Hospital, Zhenjiang, China
Background/Purpose Follicular helper T (Tfh) cells have been identified as a new subset of effector helper T cells that are essential in regulating the development…
Abstract Number: 2165 • 2014 ACR/ARHP Annual Meeting
Myeloid-Derived Suppressor Cells in Rheumatoid Arthritis: Friend or Foe?
Fanlei Hu¹, Chunqing Guo², Xiang-Yang Wang² and Zhanguo Li¹, ¹Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ²Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA
Background/Purpose Although myeloid-derived suppressor cells (MDSCs) have been linked to T-cell tolerance, their role in rheumatoid arthritis (RA) remains exclusive. Here, we investigated the potential…
Abstract Number: 1963 • 2014 ACR/ARHP Annual Meeting
Hierarchical Role of PI3K/Akt/mTOR Signaling Cascade on: Tissue Inflammation, Organization and Angiogenesis in Autoimmune Arthritis
Siba Raychaudhuri¹, Anupam Mitra², Ananya Datta Mitra³, Christine Abria⁴ and Smriti K. Raychaudhuri³, ¹Med/Rheumatology, Univ California Davis/VA Sac, Davis, CA, ²Dermatology, VA Sacramento Medical Center, Mather, CA, ³Rheumatology, VA Sacramento Medical Center, Mather, CA, ⁴Research, VA Sacramento Medical Center, Mather, CA
Background/Purpose: The PI3K/Akt/mTOR signaling proteins are pro-growth/pro-survival and thus likely to regulate inflammatory cascades in autoimmune diseases (1). The key pathologic outcome in psoriatic arthritis…
Abstract Number: 1740 • 2014 ACR/ARHP Annual Meeting
Predicting the Evolution of Inflammatory Arthritis in ACPA-Positive Individuals: Can T-Cell Subsets Model Help?
Laura Hunt¹, Agata Burska², Elizabeth M.A. Hensor¹, Jackie L. Nam¹, Frederique Ponchel¹ and Paul Emery¹, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds., Leeds, United Kingdom
Background/Purpose: ACPA+ individuals with non-specific musculoskeletal symptoms are at high risk of developing rheumatoid arthritis (RA). We previously demonstrated dys-regulation of T-cell subsets with loss…
Abstract Number: 1466 • 2014 ACR/ARHP Annual Meeting
Patients with Active Rheumatoid Arthritis Display an Expanded Population of GM-CSF Expressing Peripheral B Cells
Sofia Adamidi, Anastasia Makris, Christos Koutsianas, Christina Tsalapaki, Emilia Hadziyannis and Dimitrios Vassilopoulos, 2nd Department of Medicine and Laboratory of Clinical Immunology-Rheumatology, Hippokration General Hospital, University of Athens Medical School, Athens, Greece
Background/Purpose GM-CSF has been implicated in rheumatoid arthritis (RA) pathogenesis and is being investigated as a novel therapeutic target. B cells secreting GM-CSF have been…
Abstract Number: 1457 • 2014 ACR/ARHP Annual Meeting
Stem Cell Growth Factor Expression in Rheumatoid Arthritis
Youn Jung Woo¹, Young Ae Baik¹, Yong-Beom Park², Soo-Kon Lee³, William H. Robinson⁴ and Jason Jungsik Song³, ¹Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ³Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ⁴Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Stem cell growth factor (SCGF) is a member of the C-type lectin superfamily, encoded by gene CLEC11A. SCGF is not related to stem cell…

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