Abstracts tagged "pathogenesis"

Abstract Number: 2669 • 2012 ACR/ARHP Annual Meeting
TLR7 Ligation Contributes to Monocyte Migration in Rheumatoid Arthritis
Nathan D. Chamberlain¹, Seung-jae Kim¹, Michael Volin², William Swedler³, Suncica Volkov¹ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ³Section of Rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of the study was to characterize the expression of TLR7 in rheumatoid arthritis (RA) peripheral blood (PB) cells and to examine the…
Abstract Number: 1595 • 2012 ACR/ARHP Annual Meeting
Genome-Wide Association Study to High -Throughput Cell-Based Phenotypic Screen Identifies Novel Chemical Inhibitors of CD40 Signaling
Gang Li¹, Dorothee Diogo², Di Wu¹, Jim Spoonamore³, Rheumatoid Arthritis Consortium International (RACI)⁴, Eli Stahl⁵, Nicola Tolliday³ and Robert M. Plenge⁶, ¹Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ³Broad Institute, Cambridge, MA, ⁴Boston, ⁵Brigham and Women's Hospital, ⁶Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Deriving therapeutic targets from human genetics linked with biological alterations of risk alleles may provide a more successful approach to drug development than traditional…
Abstract Number: 1199 • 2012 ACR/ARHP Annual Meeting
Proteases Produced by Porphyromonas Gingivalis Can Cleave and Citrullinate Substrates Found in the Joint and Oral Mucosa: Implications for Autoimmunity in Rheumatoid Arthritis
Nidhi Sofat¹, Saralili Robertson² and Robin Wait³, ¹Rheumatology, St. George's University of London, London, United Kingdom, ²Biomedical Sciences, St. George's University of London, London, United Kingdom, ³Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterised by inflammation followed by tissue rebuilding or fibrosis. Failure by the body to effectively regulate inflammation…
Abstract Number: 1201 • 2012 ACR/ARHP Annual Meeting
Anti-Citrullinated Protein Antibody Specific Fc Glycosylation Patterns in Arthralgia Patients
Hans Ulrich Scherer¹, Yoann Rombouts², Ewoud Ewing³, Lotte van de Stadt⁴, Maurice H.J. Selman⁵, André M. Deelder³, Tom W.J. Huizinga², Manfred Wuhrer⁵, Dirkjan van Schaardenburg⁶ and René E.M. Toes², ¹Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands, ⁴Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ⁵Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands, ⁶Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) exhibit a specific, pro-inflammatory Fc glycosylation profile characterized by a low content of galactose and sialic acid residues. The absence…
Abstract Number: 1204 • 2012 ACR/ARHP Annual Meeting
Porphyromonas Gingivalis Antibody Responses and Clinical Associations in Patients with Early Rheumatoid Arthritis
Sheila L. Arvikar¹, Klemen Strle², Deborah S. Collier³, Mark C. Fisher¹, Gail McHugh⁴, Toshihisa Kawai⁵, Alpdogan Kantarci⁶ and Allen C. Steere⁷, ¹Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Rheumatology, Massachusetts General Hospital, Boston, MA, ⁴Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ⁵Forsyth Institute, Cambridge, MA, ⁶Forsyth Institute, Forsyth Institute, Cambridge, MA, ⁷Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA
Background/Purpose: Three prior studies have demonstrated an increased frequency of antibody responses to P. gingivalis (Pg), a leading agent of periodontal disease (PD), in RA…
Abstract Number: 1177 • 2012 ACR/ARHP Annual Meeting
Talin Is Cleaved and Expressed As a Short Form in Patients with Rheumatoid Arthritis
Kensei Tsuzaka¹, Masako Takao¹, Naoshi Shinozaki² and Jiro Nishida¹, ¹Dept of Internal Medicine, Ichikawa General Hospital,TDC, Ichikawa, Chiba, Japan, ²Cornea Center, Ichikawa General Hospital, TDC, Ichikawa, Japan
Methods: Western Blot analysis showed that the N-terminal 32kDa and the C-terminal 15kDa of calpain1 fragment of talin (32kDa and 15kDa short-talin, respectively) was expressed…
Abstract Number: 1181 • 2012 ACR/ARHP Annual Meeting
The Role of á-Defensin-1 and Its Signal Transduction Mechanisms in the Production of IL-6, IL-8 and MMPs in Rheumatoid Fibroblast-Like Synoviocytes
Joong Kyong Ahn¹, Bo Huang², Eun-Jung Park², Jiwon Hwang³, Jaejoon Lee², Chan Hong Jeon⁴, Eunmi Koh² and Hoon-Suk Cha⁵, ¹Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³Department of Medicine,Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea, ⁵Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose: Fibroblast-like synoviocytes (FLS) play an essential role in the pathophysiology of rheumatoid arthritis (RA). Also, neutrophils are the most abundant cell type of synovial…

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