Abstracts tagged "pathogenesis"

Abstract Number: 408 • 2012 ACR/ARHP Annual Meeting
Alpha-Enolase Facilitates Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
Kichul Shin¹, Ji Ah Park², Seyeon Bae³, Jae Seung Kang³ and Yeong Wook Song⁴, ¹Rheumatology, College of Medicine, Seoul National University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine,, Seoul National Hospital, Seoul, South Korea, ³Department of Anatomy and Tumor Immunity Medical Research Center, College of Medicine, Seoul National University, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea
Background/Purpose:Alpha-enolase (ENO1) is a multifunctional glycolytic enzyme ubiquitously expressed in the cytoplasm. Citrullinated ENO1 is reported to be a candidate autoantigen in rheumatoid arthritis (RA),…
Abstract Number: 1767 • 2012 ACR/ARHP Annual Meeting
Circulating Plasmablasts As a Source of Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis
Priscilla Kerkman, Ellen I.H. van der Voort, Leendert A. Trouw, Tom W.J. Huizinga, René E.M. Toes and Hans Ulrich Scherer, Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Anti citrullinated protein antibodies (ACPA) are highly specific for rheumatoid arthritis (RA) and predict disease onset and severity. Accumulating evidence indicates that ACPA could…
Abstract Number: 328 • 2012 ACR/ARHP Annual Meeting
IL-7; An Important Pro-Inflammatory Factor That Affects Myeloid Cell Function in RA and CIA
Nathan D. Chamberlain¹, Seung-jae Kim², Michael Volin³, Anjali Mehta², Nadera J. Sweiss⁴ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²University of Illinois at Chicago, Chicago, IL, ³Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ⁴internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of the study was to examine the role of IL-7 in the pathogenesis of rheumatoid arthritis (RA) as well as in collagen…
Abstract Number: 1690 • 2012 ACR/ARHP Annual Meeting
Citrullination within the Atherosclerotic Plaque: A New Potential Target for Anti-Citrullinated Protein Antibodies
Jeremy Sokolove¹, Orr Share¹, Matthew Brennan¹, Lauren J. Lahey¹, Amy H. Kao², Eswar Krishnan³, Mary Chester M. Wasko⁴ and William H. Robinson⁵, ¹Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ²Lupus Center of Excellence, Allegheny Singer Research Institute, Pittsburgh, PA, ³Medicine, Standford University, Palo Alto, CA, ⁴West Penn Allegheny Health System, Temple University School of Medicine, Pittsburgh, PA, ⁵Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk for cardiovascular disease due to accelerated atherosclerosis. This risk has mainly been limited to seropositive…
Abstract Number: 36 • 2012 ACR/ARHP Annual Meeting
Role of FK506 Binding Protein 5 in Osteoclast Differentiation
Miho Kimura¹, Tatsuo Nagai², Reiko Matsushita², Atsushi Hashimoto³, Toshiyuki Miyashita⁴ and Shunsei Hirohata⁵, ¹Rheumatology and Infectious diseases, Kitasato University School of Medicine, Sagamihara, Japan, ²Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, ³Department of Rheumatology, National Hospital Organization Sagamihara Hospital, Kanagawa, Japan, ⁴Molecular Genetics, Kitasato University School of Medicine, Sagamihara, ⁵Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: RA is a chronic, systemic inflammatory disease characterized by the destruction of bone in the joints. Moreover, it is well appreciated that systemic osteoporosis…
Abstract Number: 1692 • 2012 ACR/ARHP Annual Meeting
Lung Microbiome Differs in Subjects with Rheumatoid Arthritis-Related Autoimmunity without Inflammatory Arthritis Compared to Healthy Seronegative Controls
M. Kristen Demoruelle¹, Jill M. Norris², V. Michael Holers³, Kevin D. Deane¹ and J. Kirk Harris⁴, ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁴University of Colorado Anschutz Medical Campus, Aurora, CO
Background/Purpose: Emerging data suggest that microorganisms and mucosal inflammation may play a role in the etiology of rheumatoid arthritis (RA). Furthermore, our published findings…
Abstract Number: 2669 • 2012 ACR/ARHP Annual Meeting
TLR7 Ligation Contributes to Monocyte Migration in Rheumatoid Arthritis
Nathan D. Chamberlain¹, Seung-jae Kim¹, Michael Volin², William Swedler³, Suncica Volkov¹ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ³Section of Rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of the study was to characterize the expression of TLR7 in rheumatoid arthritis (RA) peripheral blood (PB) cells and to examine the…

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