Abstracts tagged "pathogenesis and systemic sclerosis"

Abstract Number: 1109 • 2018 ACR/ARHP Annual Meeting
Gene Expressions of TMEM176A and TMEM176B Were Prominent at the Stage of Subclinical Pulmonary Vascular Disease in Systemic Sclerosis
Yoshinobu Koyama¹, Soichiro Fuke², Takashi Ohno³, Yoshiharu Sato⁴ and Toshie Higuchi¹, ¹Center for Autoimmune Diseases, Division of Rheumatology, Japan Red Cross Okayama Hospital, Okayama, Japan, ²Department of Cardiology, Japan Red Cross Okayama Hospital, Okayama, Japan, ³Management of medical safety, Okayama University Hospital, Okayama, Japan, ⁴DNA Chip Research Inc, Tokyo, Japan
Background/Purpose: Pulmonary arterial hypertension (PAH) is prominent as a vascular involvement of systemic sclerosis (SSc), which remains a leading cause of death in spite of…
Abstract Number: 1920 • 2015 ACR/ARHP Annual Meeting
Differential Production of Th17-Related Cytokines By Toll like Receptor (TLR)-Ligands-Stimulated Monocyte-Derived Dendritic Cells (Mo-DCs) from Systemic Sclerosis (SSc) Patients; Relevance of IL-22 and IL-33 According to Disease Subtype and Stage
Tatiana Sofia Rodriguez-Reyna¹, Adrián Caballero¹, Luís Jiménez-Álvarez², Gustavo Ramirez², José Eduardo Márquez García², Alfredo Cruz Lagunas³, Guadualupe Lima⁴, Janette Furuzawa-Carballeda⁵, Luis Llorente¹ and Joaquin Zuniga⁶, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Immunology, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico, ³Immunology, Instituto Nacional de Enfermedades Respiratorias, Mexico, Mexico, ⁴Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, ⁶Immunology, Instituo Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico, Mexico
Background/Purpose: Systemic sclerosis (SSc) patients exhibit alterations in innate and acquired cellular responses including an enhanced inflammatory response to toll like receptor (TLR) agonists that…
Abstract Number: 3012 • 2015 ACR/ARHP Annual Meeting
Over-Expression of Ubiquitin-Specific Peptidases in Systemic Sclerosis Fibroblasts Increases Responses to TGF-Beta
Christine Galant, Joëlle Marchandise, Julie Ducreux, Maria Stoenoiu, Frédéric A. Houssiau and Bernard R. Lauwerys, Pôle de pathologies rhumatismales inflammatoires et systémiques, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium
Background/Purpose: Ubiquitination of proteins leads to their degradation by the proteasome, and is regulated by a small number of ubiquitin ligases, and a large number…
Abstract Number: 2703 • 2014 ACR/ARHP Annual Meeting
Elevated Serum Levels of Endostatin in Mixed Connective Tissue Disease – Association with Pulmonary Fibrosis and Digital Ulcers
Silje Reiseter¹, Ragnar Gunnarsson², Torhild Garen², May Brit Lund³, T. Mogens Aalokken⁴, Anna-Maria Hoffmann-Vold⁵, Øyvind Molberg^2,6 and Thor Ueland⁷, ¹Department of Rheumatology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, ²Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway, ³Department of Respiratory Medicine, Oslo University Hospital Rikshopitalet, Oslo, Norway, ⁴Department of Radiology, Oslo University Hospital Rikshospitalet, Oslo, Norway, ⁵Department of Rheumatology, Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway, ⁶Institute of Clinical Medicine, University of Oslo, Oslo, Norway, ⁷Research Institute for Internal Medicine, University of Oslo, Oslo, Norway
Background/Purpose Mixed Connective Tissue Disease (MCTD) is a chronic, immune-mediated disorder defined by the combined presence of serum anti-RNP antibodies and selected clinical features of…
Abstract Number: 1708 • 2014 ACR/ARHP Annual Meeting
The Pathogenic Role of Immune Complexes Containing Scleroderma-Specific Autoantibodies in the Inductor Phase of the Disease
Cecilia B. Chighizola¹, Elena Raschi², Laura Cesana², Silvana Zeni³, Maria Orietta Borghi⁴ and Pier Luigi Meroni^5,6, ¹Rheumatology, Istituto Auxologico Italiano, University of Milan, Cusano Milanino, Italy, ²Istituto Auxologico Italiano, Milan, Italy, ³Division of Rheumatology, Istituto G. Pini, Milano, Italy, ⁴Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy, ⁵Department of Clinical Sciences and Community Health, Division of Rheumatology, Istituto G. Pini, Milan, Italy, ⁶Chair and Division of Rheumatology, Gaetano Pini Institute, University of Milan, Milan, Italy
Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune condition characterized by excessive tissue fibrosis, microvascular alterations and immune dysfunction with the production of peculiar autoantibodies.…
Abstract Number: 2564 • 2013 ACR/ARHP Annual Meeting
Functional Activation Of The TRPV1 and TRPV2 Non-Selective Cation Channels Potentiates TGF-β1-Induced Endothelial-To-Mesenchymal Transition In Murine Pulmonary Endothelial Cells Suggest a Potential Role Of Trpv Channels In The Pathogenesis Of Systemic Sclerosis
Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Transient receptor potential (Trp) cation channel, subfamily V (TRPV) members can impact a diverse range of vascular functions, including vascular tone, vascular permeability, mechanosensing,…
Abstract Number: 2565 • 2013 ACR/ARHP Annual Meeting
Synergistic Effects Of Endothelin-1 On Transforming Growth Factor-β1 (TGF-β1) Induced Endothelial-To-Mesenchymal Transition. A Novel Mechanism For The Fibrogenic Effects Of Endothelin
Peter J. Wermuth, Zhaodong Li and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: The process of endothelial-to-mesenchymal transition (EndoMT) may be a crucial pathway in the generation of activated myofibroblasts, cells that play a pivotal role in…
Abstract Number: L2 • 2013 ACR/ARHP Annual Meeting
Proteome-Wide Analysis and CXCL4 As a Pathogenic Biomarker in Systemic Sclerosis
Timothy Radstake¹, Lenny van Bon², Alsya Affandi¹, Jasper Broen³, Romy Christmann⁴, Lukasz Stawski⁵, Giuseppina Farina⁶, Allison Mathes⁷, Marta Cossu⁸, MArk Wenink⁹, Roger Hesselstrand¹⁰, Tore Saxne¹¹, Dirk Wuttge¹⁰, John D. Reveille¹², Shervin Assassi¹², Maureen D. Mayes¹³, Wim B van den Berg¹⁴, Vanessa Smith¹⁵, Filip De Keyser¹⁵, Claudio Lunardi¹⁶, Piet L.C. Van Riel¹⁷, Madelon C. Vonk¹⁸, Lorenzo Beretta¹⁹, Maria Trojanowska²⁰ and Robert Lafyatis⁴, ¹Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Utrecht/Radboud University Nijmegen Medical Center, Utrecht/Nijmegen, Netherlands, ³Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Rheumatology, Boston University School of Medicine, Boston, MA, ⁵Rheumatology, Boston Medical Center, Boston, MA, ⁶Arthritis center, Boston University, Boston, MA, ⁷rheumatology, Boston Medical Center, boston, MA, ⁸Rheumatology and Clinical Immunology, University Medical Center Utrecht, utrecht, Netherlands, ⁹rheumatology and Clinical Immunology, university Medical Center Utrecht, utrecht, Netherlands, ¹⁰Rheumatology, Lund University, Lund, Sweden, ¹¹Section of Rheumatology, Deparment of Clinical Sciences, Lund, Lund University, Lund, Sweden, ¹²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ¹³University of Texas Health Science Center at Houston, Houston, TX, ¹⁴Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ¹⁵Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ¹⁶Department of Medicine, Università degli Studi di Verona, Verona, Italy, ¹⁷Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹⁸Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹⁹Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ²⁰Arthritis Center, Boston University, Boston, MA
Background/Purpose: We hypothesized that plasmacytoid dendritic cells are implicated in the pathogenesis of systemic sclerosis via mechanisms beyond previously suggested type I interferon production. Methods:…

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