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Abstracts tagged "pathogenesis and synovitis"

  • Abstract Number: 575 • ACR/ARHP Annual Meeting 2016

    Differences in Histological Scores and Histoclinical Correlations in ACPA- Versus ACPA+ Rheumatoid Arthritis Patients

    Fadil Pirbuccus1, Christine Galant1, Adrien Nzeusseu Toukap2, Frédéric A. Houssiau1, Patrick Durez2 and Bernard R. Lauwerys1, 1Pôle de pathologies rhumatismales inflammatoires et systémiques, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, 2Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium

    Background/Purpose:  Differences in the pathogenesis of ACPA- versus ACPA+ rheumatoid arthritis are still poorly understood. In this study, we compared patterns of synovial changes in…
  • Abstract Number: 3124 • ACR/ARHP Annual Meeting 2016

    Huntingtin Interacting Protein 1 (Hip1) Is a New Arthritis Severity Gene

    Teresina Laragione1, Percio Gulko1 and Max Brenner2, 1Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, 2Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose:  Cia25/Pia42 is an arthritis severity and joint damage quantitative trait locus on rat chromosome 12 previously identified in an intercross between MHC identical but…
  • Abstract Number: 2401 • ACR/ARHP Annual Meeting 2013

    Disease Activity (DAS-28CRP) In Rheumatoid Arthritis Correlates With Synovial Expression Of Tumor-Associated and IL-6-Dependent Genes

    Bernard Lauwerys1, Julie Ducreux2, Adrien Nzeusseu Toukap1, Valérie Badot3, Frédéric A. Houssiau2 and Patrick Durez1, 1Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, 2Institut de Recherche Expérimentale et Clinique, Pôle de Maladies Rhumatismales, Université catholique de Louvain, Brussels, Belgium, 3Department of Rheumatology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium

    Background/Purpose: The molecular mechanisms that regulate disease activity in rheumatoid arthritis (RA) are unknown. Using high-throughput transcriptomic data sets generated in knee synovial biopsies from…

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