Abstracts tagged "paraoxonase and rheumatoid arthritis (RA)"

Abstract Number: 66 • 2018 ACR/ARHP Annual Meeting
Suppression of Inflammatory Arthritis, in Human Paraoxonase 1 Transgenic Mice, Correlates with Upregulation of the Hepatic Glutathione Pathway and Reduction of Bioactive Lipid Mediators
Christina Charles-Schoeman¹, Ani Shahbazian², Jennifer Wang³, Xiaoyan Wang², Ernest Brahn², Jeremy Papesh², Victor Grijalva⁴ and Srinivasa T. Reddy², ¹Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²University of California, Los Angeles, Los Angeles, CA, ³University of California Los Angeles, Los Angeles, CA, ⁴Medicine-Cardiology, University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Paraoxonase 1 (PON1) is an HDL-associated protein, which hydrolyzes biologically active oxidized phospholipids and prevents oxidation of lipids in LDL and HDL. Increased lipid…
Abstract Number: 1562 • 2016 ACR/ARHP Annual Meeting
Interaction Between Antibodies to Paraoxonase 1 and PON1 rs662 Polymorphism: New Clues to Understand HDL Dysfunction and Oxidative Stress in Rheumatoid Arthritis
Javier Rodríguez-Carrio¹, Mercedes Alperi-López², Raquel López-Mejías³, Patricia López¹, Francisco Javier Ballina-García², Francisco Abal⁴, Miguel Angel Gonzalez-Gay^3,5 and Ana Suárez¹, ¹Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ²Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, ³Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ⁴Centro de Salud Sariego, Siero, Servicio de Salud del Principado de Asturias (SESPA), Siero, Spain, ⁵School of Medicine, University of Cantabria, Santander, Spain
Background/Purpose: Traditional and non-traditional cardiovascular (CV) risk factors underlie CV disease occurrence in rheumatoid arthritis (RA). Recently, a functional impairment of HDL antioxidant capacity has…