Abstracts tagged "pain"

Abstract Number: 0789 • ACR Convergence 2024
An Online Trial to Assess the Efficacy and Safety of a Supplement Combination in People with Hand Osteoarthritis
Xiaoqian Liu¹, Sarah Robbins¹, Jillian Eyles¹, Leticia Deveza¹, Andrew McLachlan¹ and David Hunter², ¹The University of Sydney, Sydney, New South Wales, Australia, ²Sydney Musculoskeletal Health, University of Sydney, St Leonards, New South Wales, Australia
Background/Purpose: Hand osteoarthritis is a debilitating and highly prevalent disease with limited treatment options. The aim of this study was to investigate the efficacy and…
Abstract Number: 1197 • ACR Convergence 2024
Safety and Immunogenicity of an Active Anti-IL-6 Immunotherapy in a Phase 1 Clinical Trial in Knee Osteoarthritis Patients
François Rannou¹, Christelle Nguyen¹, Camille Daste¹, Quentin Kirren¹, marie-martine Lefevre-Colau¹, Odile Launay², Lucille Desallais³, Edita Dolimier³, René Azoulai³, Jean-Pierre Salles³ and Jean-François Zagury⁴, ¹AP-HP. Centre-Université Paris Cité, Hôpital Cochin, Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis, Paris, Ile-de-France, France, ²Centre d’Investigation Clinique en Vaccinologie (CIC Cochin Pasteur), Hôpital Cochin, Paris, Ile-de-France, France, ³Peptinov, Paris, Ile-de-France, France, ⁴Laboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA 7528, Chaire de Bioinformatique, Conservatoire National des Arts et Métiers, Paris, Ile-de-France, France
Background/Purpose: Interleukin-6 (IL-6) is a major inflammatory cytokine involved in pain and potentially in osteoarthritis (OA) disease progression. PPV-06 is an IL-6-derived peptide coupled with…
Abstract Number: 1227 • ACR Convergence 2024
Longitudinal Patterns of Fibromyalgia Phenotypes in Patients with Systemic Lupus Erythematosus
Brooke Cohen¹, Philip Carlucci², Kelly Corbitt³, Mala Masson⁴, Amit Saxena⁵, H Michael Belmont⁵, Chung-E Tseng⁶, Rachel Wu⁷, Hamleini Martinez⁷, George Kenefati⁷, Lisa Doan⁷, Jing Wang⁸, Kamil Barbour⁹, Heather Gold⁷, Jill Buyon¹⁰ and Peter Izmirly¹¹, ¹NYU Langone, NYC, NY, ²New York University School of Medicine, New York, NY, ³University of Miami Miller School of Medicine, El Portal, FL, ⁴NYU Langone Medical Center- Division of Rheumatology, New York, NY, ⁵NYU School of Medicine, New York, NY, ⁶NYU Langone Health, Flushing, NY, ⁷NYU Langone Health, NYC, ⁸NYU Langone Health, NYC, NY, ⁹CDC, Alpharetta, GA, ¹⁰NYU Grossman School of Medicine, New York, NY, ¹¹New York University Grossman School of Medicine, New York, NY
Background/Purpose: Fibromyalgia (FM) is a common comorbidity in patients with systemic lupus erythematosus (SLE) and a major contributor to poor health related quality of life.…
Abstract Number: 1892 • ACR Convergence 2024
Early Tumor Necrosis Factor Inhibitor Initiation and Chronic Opioid Use in Individuals with Axial Spondyloarthritis
Eva Petrow¹, Jose Meade Aguilar², Christine Peloquin³, S. Reza Jafarzadeh³, Tuhina Neogi³, Maureen Dubreuil⁴ and Jean Liew³, ¹Boston University/Boston Medical Center, Boston, MA, ²Boston Medical Center, Boston, MA, ³Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁴Section of Rheumatology, Boston University School of Medicine, Boston, MA
Background/Purpose: Patients with axial spondyloarthritis (axSpA) bear a substantial burden of chronic opioid use despite the availability of effective treatments like tumor necrosis factor inhibitors…
Abstract Number: 2173 • ACR Convergence 2024
Hope and Health in Adolescents with Chronic Musculoskeletal Pain
Irene Chern¹, Mackenzie McGill², Nellie P Butler² and Sabrina Gmuca², ¹St. Christopher's Hospital for Children, Philadelphia, PA, ²Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Hope, the capability to derive pathways to desired goals and motivate oneself via agency thinking plays a protective role in pediatric health contributing to…
Abstract Number: L19 • ACR Convergence 2023
A Phase 3 Study of Repeat Injection of TLC599 in Osteoarthritis of the Knee: Benefits to 52 Weeks
George Spencer-Green¹, David Hunter², Thomas Schnitzer³, Sheue-Fang Shih⁴, Tien-Tzu Tai⁴, Cathy Kao⁴ and Siao-Ning Huang⁴, ¹Taiwan Liposome Company, Cambridge, MA, ²Sydney Musculoskeletal Health, University of Sydney, St Leonards, New South Wales, Australia, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Taiwan Liposome Company, Taipei, Taiwan (Republic of China)
Background/Purpose: In osteoarthritis (OA) of the knee, intraarticular injections of corticosteroids can relieve pain, reduce inflammation, and improve mobility, but the effect is not predictable,…
Abstract Number: 0309 • ACR Convergence 2023
Efficacy, Safety, Pharmacokinetics and Immunogenicity of Repeated Dosing of GSK3858279 in Patients with Knee Osteoarthritis: A Phase I, Randomized, Double-Blind, Placebo-Controlled Study
Jagtar Singh Nijjar¹, Kathy Abbott-Banner², Riju Ray³, Sam Munoz Vicente¹, Jane H. Bentley¹, Catherine Muya¹, Sarah Siederer¹, Eirini Panoilia¹, Damon Bass⁴, Disala Fernando⁵ and Edward C. Emery¹, ¹GlaxoSmithKline, Stevenage, United Kingdom, ²GlaxoSmithKline, Brentford, United Kingdom, ³GSK Research, Triangle Park, ⁴GlaxoSmithKline, Upper Providence, RI, ⁵GlaxoSmithKline, Cambridge, United Kingdom
Background/Purpose: Chronic pain is an unmet need in osteoarthritis (OA) as current therapies have limited analgesia and side effects. The chemokine CCL17 mediates inflammatory pain…
Abstract Number: 0721 • ACR Convergence 2023
Characterization of Numeric Rating Scales for Symptom Assessment in Polymyalgia Rheumatica
Tonya K Marmon¹, Jason C Cole², Claire Owen³, Sarah Mackie⁴ and David Katz⁵, ¹Marmon Biostatistics, Seattle, WA, ²P3 Research Consulting, Torrance, CA, ³Austin Health, Malvern East, Australia, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁵Sparrow Pharmaceuticals, Portland, OR
Background/Purpose: Pain, stiffness, and fatigue have been defined as core assessment domains in polymyalgia rheumatica (PMR) by the OMERACT PMR Working Group (PMRWG). Patient partners…
Abstract Number: 1184 • ACR Convergence 2023
A Wearable-Sensor for Assessment of Gait and Chair Stand Patterns in People with Knee Osteoarthritis: Validation and Responsiveness to Treatment of a Potential Digital Biomarker
Deepak Kumar¹, Lukas Adamowicz², Benjamin Senderling¹, Mary Gheller¹, Michael LaValley³, Kathryn Bacon¹, Pirinka Georgiev², Charmaine Demanuele², Paul Wacnik² and Tuhina Neogi⁴, ¹Boston University, Boston, MA, ²Pfizer Inc., Cambridge, MA, ³Boston University School of Public Health, Arlington, MA, ⁴Boston University School of Medicine, Boston, MA
Background/Purpose: The objectives of this study in people with knee osteoarthritis (OA) were to (a) examine the agreement between measures of gait and chair stand…
Abstract Number: 1595 • ACR Convergence 2023
Pharmacological Modulation of Krüppel-like Factor 4 Reduces the Severity of Experimental Osteoarthritis via Tissue Protection and Regeneration
Manabu Kawata¹, Merissa Olmer², Kristen Johnson³ and Martin K Lotz², ¹Scripps Research Institute, San Diego, CA, ²Scripps Research Institute, La Jolla, CA, ³CALIBR, La Jolla, CA
Background/Purpose: Krüppel-like factors (KLFs) are members of the zinc finger family of transcription factors, which includes 17 members in mammals. We found that expression of…
Abstract Number: 1836 • ACR Convergence 2023
Embracing a Biopsychosocial Approach to Fibromyalgia-like Symptoms in People with SLE: Insights from the Type 2 SLE Consortium
Jennifer Rogers¹, Megan Clowse² and Amanda Eudy³, ¹Duke University, Durham, NC, ²Duke University, Chapel Hill, NC, ³Duke University, Raleigh, NC
Background/Purpose: Patients with SLE experience distressing fibromyalgia-like symptoms of fatigue, widespread pain, mood disturbance, and brain fog that negatively impact quality of life and are…
Abstract Number: 2155 • ACR Convergence 2023
The Impact of Filgotinib on Disease Activity Outcomes with Concomitant Pain Control in the Phase 3 FINCH Studies
Peter C. Taylor¹, Arthur Kavanaugh², Peter Nash³, Janet Pope⁴, Georg Pongratz⁵, Bruno Fautrel⁶, Rieke Alten⁷, Ken Hasegawa⁸, Shangbang Rao⁹, Dick de Vries¹⁰, Pieter-Jan Stiers¹¹, Chris Watson¹² and René Westhovens¹³, ¹Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Division of Rheumatology, Allergy, and Immunology, University of California San Diego, La Jolla, CA, ³School of Medicine, Griffith University, Brisbane, Australia, ⁴University of Western Ontario, London, ON, Canada, ⁵Faculty of Medicine, Regensburg University, Regensburg, Germany, Regensburg, Germany, ⁶Sorbonne Université APHP, Paris, France, ⁷Department of Internal Medicine and Rheumatology, Schlosspark Klinik, University Medicine Berlin, Berlin, Germany, ⁸Global Medical Affairs Research, Gilead Sciences, Inc., Foster City, CA, ⁹Biostatistics, Gilead Sciences, Inc., Foster City, CA, ¹⁰Research and Development, Clinical Research, Galapagos BV, Leiden, Netherlands, ¹¹Biostatistics, Galapagos NV, Mechelen, Belgium, ¹²Medical Affairs, Galapagos Biotech Ltd., Cambridge, United Kingdom, ¹³Department of Rheumatology, KU Leuven, Skeletal Biology and Engineering Research Center, Leuven, Belgium
Background/Purpose: Patients (pts) with rheumatoid arthritis (RA) often experience substantial pain despite treatment, and consider pain control an important treatment outcome. This post hoc analysis…
Abstract Number: 0313 • ACR Convergence 2023
The Influence of Pain Catastrophizing on Pain and Function After Knee Arthroplasty for Osteoarthritis
Diana, Xin Hui Chan¹, Seyed Ehsan Saffari², Steven, Bak Siew Wong³, Seng Jin Yeo¹, Vikki Wylde⁴, Julian Thumboo¹ and Ying Ying Leung¹, ¹Singapore General Hospital, Singapore, Singapore, ²Center for Quantitative Medicine, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore, ³Sengkang General Hospital, Singapore, Singapore, ⁴University of Bristol, Bristol, United Kingdom
Background/Purpose: To evaluate the association between pre-operative pain catastrophizing and pain and function outcomes up to one year after knee arthroplasty. Methods: We used data…
Abstract Number: 0756 • ACR Convergence 2023
Validation of Quantitative Effusion-synovitis Volume Measured by Deep-learning: Data from the Osteoarthritis Initiative
Banafshe Felfeliyan¹, Stephanie Wichuk², Abhilash Hareendranathan³, Janet Ronsky⁴ and Jacob Jaremko², ¹University of Alberta, Calgary, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³Radiology and Diagnostic Imaging, Edmonton, AB, Canada, ⁴University of Calgary, Calgary, AB, Canada
Background/Purpose: Knee effusion-synovitis (ES) is an attractive target for therapeutic interventions in arthritis, since it is associated with stiffness, pain, and disease progression to arthroplasty.…
Abstract Number: 1189 • ACR Convergence 2023
Evaluating Neuropathic and Nociplastic Pain in Patients with Hip and Knee Osteoarthritis
Carly Conran¹, Larry Moreland², Andrew Clauw¹, Jennifer Seifert¹, Carson Keeter³, Craig Hogan¹ and Michael Dayton¹, ¹University of Colorado Anschutz Medical Campus, Aurora, CO, ²University of Colorado, Denver, CO, ³University of Colorado, Aurora, CO

Background/Purpose: Chronic pain in patients with hip and knee osteoarthritis (OA) has been classically attributed to nociceptive pain pathways. Emerging evidence has demonstrated influence from…

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