Abstracts tagged "pain"

Abstract Number: 0326 • ACR Convergence 2025
Gender Disparities in Clinical Outcomes Among Older Adults with Knee Osteoarthritis: A Retrospective Cohort Study
Kinga Grzybowski¹, Ahmer Khan², Samuel Bonomo³ and Arthur Lau⁴, ¹Jefferson Einstein Montgomery Hospital, Maspeth, NY, ²Jefferson Einstein Philadelphia Hospital, Philadelphia, ³Jefferson Einstein Montgomery Hospital, East Norriton, PA, ⁴Jefferson Einstein Hospital, Maple Glen, PA
Background/Purpose: Osteoarthritis (OA) is the most common type of arthritis which classically affects multiple joints, mainly the knees. About 595 million people worldwide suffer from…
Abstract Number: 2096 • ACR Convergence 2025
Gamification and Social Incentivization to Promote Physical Activity in Adults with Knee Osteoarthritis: Results from a Multi-Site Randomized Trial
Kimberly Hayes¹, Bryant England², Katherine Wysham³, Mercedes Quinones⁴, Marianna Olave⁵, Sarah Wetzel⁶, Hannah Brubeck⁷, Rachel Gillcrist⁸, Criswell Lavery⁹, Natalie Keller¹⁰, Bibiana Ateh¹¹, Bridget Kramer², Rui Xiao⁹, Kaitian Jin⁹, Alexis Ogdie¹², Daniel K. White¹³, Tuhina Neogi¹⁴, Carla Scanzello⁹ and Joshua Baker⁹, ¹Teachers College, Columbia University, Philadelphia, PA, ²University of Nebraska Medical Center, Omaha, NE, ³VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, ⁴Washington DC VA Medical Center, Bethesda, MD, ⁵Brown University, Philadelphia, PA, ⁶Drexel University, Pittsburgh, PA, ⁷VA Puget Sound Health Care System, Seattle, WA, ⁸Dartmouth College, Lebanon, NH, ⁹University of Pennsylvania, Philadelphia, PA, ¹⁰University of Oklahoma, Philadelphia, PA, ¹¹Washington VA Medical Center, Washington, District of Columbia, ¹²Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Wilmington, DE, ¹³University of Delaware, Newark, DE, ¹⁴Boston University School of Medicine, Boston, MA
Background/Purpose: Promotion of physical activity is important in the management of knee osteoarthritis (KOA), though effective strategies for behavioral change to promote exercise are lacking.…
Abstract Number: 1737 • ACR Convergence 2025
CR10049, the first intra-articular Src family kinase inhibitor as a long-acting symptom- and disease-modifying drug for the inflammatory OA phenotype
Luigino Giancotti, Tiziana Piepoli, Roberto Artusi, Matteo Ghirri, Michela Visintin, Gianfranco Caselli and Lucio Rovati, Rottapharm Biotech, Monza, Italy
Background/Purpose: The inflammatory osteoarthritis (OA) phenotype is characterized by the presence of synovial membrane inflammation, pain and pathological changes in joint structure leading to rapid…
Abstract Number: 1253 • ACR Convergence 2025
Patient Reported Outcome Measures: Assessing Resident Physician Acceptance of the Routine Assessment of Patient Index Data 3 Survey and its Impact on Physician-Patient Relationship
Nisha Sapkota¹, Chana Birnbaum², Henna Levitansky², Yevheniia Andriushchenko², Saadia Malik², Melissa Andrade², Sarang Choi² and Sima Terebelo², ¹Interfaith Medical Center, One Broolyn Health, Brooklyn, NY, ²Brookdale Hospital Medical Center, One Brooklyn Health, Brooklyn
Background/Purpose: When treating patients with rheumatological conditions, building a strong physician-patient relationship plays an important role in determining disease outcomes. The Routine Assessment of Patient…
Abstract Number: 1229 • ACR Convergence 2025
Extent versus impact: Sex-specific burden of chronic pain in older adults
Gillian Fennell¹, Sarah Tilley², Sayali Dhamne³, Angelo Demalia³, Margaret Clancy³, Mary Gheller³, Robert Edwards⁴, Emelia J Benjamin³ and Tuhina Neogi⁵, ¹Boston University Medical, Boston, MA, ²Boston University School of Medicine, Somerville, MA, ³Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁴Brigham and Women's Hospital & Harvard Medical School, Boston, MA, ⁵Boston University School of Medicine, Boston, MA
Background/Purpose: Over one third of older Americans experience chronic pain, accompanied by age-related increases in pain-related activity interference (i.e., pain burden). While pain extent (i.e.,…
Abstract Number: 0816 • ACR Convergence 2025
Persistent Pain Despite Inflammatory Control in RA: A Pooled Analysis of 7 RCTs
Andreas Kerschbaumer¹, Marlene Steiner², William H. Robinson³, Josef Smolen⁴ and Daniel Aletaha⁵, ¹Stanford University / Medical University of Vienna, Stanford, CA, ²Medical University of Vienna, Vienna, Wien, Austria, ³Stanford University, Palo Alto, CA, ⁴Division of Rheumatology, Department of Medicine ³, Medical University of Vienna, Vienna, Austria, Vienna, Austria, ⁵Medical University Vienna, Wien, Austria
Background/Purpose: Joint swelling and tenderness are clinical hallmarks of rheumatoid arthritis (RA) and central to disease assessment. Regardless of treatment type, stringent remission based on…
Abstract Number: 0325 • ACR Convergence 2025
Knee Symptom Phenotyping Incorporating Pain and Function across Different Levels of WOMAC Function in Two Cohorts: Data from the Multicenter Osteoarthritis Study (MOST) and the Osteoarthritis Initiative (OAI)
C. Kent Kwoh¹, Amanda Nelson², Rongrong Tang³, Edward J. Bedrick³, Yong Ge¹, Yvonne Golightly⁴, Zong-Ming Li³, Jean Liew⁵, Xiaoxiao Sun¹, Jeffrey Duryea⁶ and Tuhina Neogi⁵, ¹The University of Arizona Arthritis Center, University of Arizona, Tucson, AZ, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³The University of Arizona Arthritis Center, University of Arizona, Tucson, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵Boston University School of Medicine, Boston, MA, ⁶Brigham and Women’s Hospital, Boston, MA
Background/Purpose: Knee pain and functional limitations are the most common symptoms of knee OA. Understanding the various patterns of symptoms (i.e., pain and function changes…
Abstract Number: 2684 • ACR Convergence 2025
Multimodal Analysis Revealed Altered Brain Connectivity Patterns and Neuroinflammatory Processes in the Background of Difficult-To-Treat Rheumatoid Arthritis
Lilla Gunkl-Tóth¹, Gergely Orsi², Noémi Császár-Nagy³, Lili Duzsik⁴, Gábor Mátay⁴, Gábor Kumánovics⁵, Gábor Sütő², Krisztina Csókási², Szabolcs Takács⁶, Zoltán Vidnyánszky⁷, József Kun², Krisztina Takács-Lovász², Gellért Karvaly⁸, Róbert Farkas⁸, Anett Pintér⁸, Panna Királyhidi⁸, György Nagy⁸ and Zsuzsanna Helyes², ¹Semmelweis University, Budapest, Budapest, Hungary, ²University of Pécs, Pécs, Hungary, ³National University of Public Services, Budapests, Hungary, ⁴Psychosomatic Outpatient Clinic, Budapest, Hungary, ⁵University of Pecs, Pecs, Hungary, ⁶Károli Gáspár University, Budapest, Hungary, ⁷Brain Imaging Centre, Research Centre for Natural Sciences, Budapest, Hungary, ⁸Semmelweis University, Budapest, Hungary
Background/Purpose: Despite advances in rheumatoid arthritis (RA) treatment, 5–20% of patients experience persistent symptoms, particularly pain, and are classified as difficult-to-treat (D2T). Factors such as…
Abstract Number: 2093 • ACR Convergence 2025
Association of Acetaminophen Use with Clinical Outcomes in Older Adults with Osteoarthritis: A Global Propensity-Matched Retrospective Cohort Analysis
Justin Riley Lam¹, Laith Alomari², Emmanuel Otabor², Michael Hamilton², Bal Subedi³, Maxim Barnett², Fabian Rodriguez Quinonez⁴ and Irene Tan⁵, ¹Albert Einstein Medical Center, Philadelphia, PA, ²Jefferson Einstein Hospital Philadelphia, Philadelphia, PA, ³Jefferson Einstein Montogmery Hospital, Philadelphia, ⁴Einstein Medical Center Philadelphia, Philadelphia, PA, ⁵Einstein Healthcare Network Philadelphia - Jefferson Health, Bala Cynwyd, PA
Background/Purpose: Acetaminophen is widely recommended for osteoarthritis (OA) pain management due to its perceived safety profile. However, its long-term effects on clinical outcomes among older…
Abstract Number: 1736 • ACR Convergence 2025
Multi-Model Evaluation of the Impact of CD14 on Synovial Inflammation and Pain During PTOA.
Kevin Burt¹, Sanique South², Natalie Adamczyk³, Shingo Ishihara³, Vu Nguyen⁴, Robert Mauck⁴, Anne-Marie Malfait⁵, Timothy Griffin⁶, Rachel Miller⁷ and Carla Scanzello¹, ¹University of Pennsylvania, Philadelphia, PA, ²University of Oregon, Eugene, ³Rush University, Chicago, ⁴University of Pennsylvania, Philadelphia, ⁵Rush University, Oak Park, IL, ⁶Oklahoma Medical Research Foundation, Oklahoma City, ⁷Rush University Medical Center, Chicago, IL
Background/Purpose: Soluble CD14, a co-receptor of inflammatory toll-like receptor signaling that is produced primarily by monocytes/macrophages, is present in synovial fluid in patients with OA…
Abstract Number: 1249 • ACR Convergence 2025
Association between Positive Emotions and Physical Function in Early Rheumatoid Arthritis Patients
Burcu Aydemir¹, Jing Song², Lutfiyya muhammad¹, Dorothy Dunlop³, Rowland Chang¹, Wendy Marder⁴, Kevin Deane⁵, Clifton Bingham⁶, Vivian Bykerk⁷, Robert Edwards⁸, Judy Moskowitz¹ and Yvonne Lee⁹, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Worthington, MN, ³Northwestern University Feinberg School of Medicine, Chicago, ⁴University of Michigan, Ann Arbor, MI, ⁵University of Colorado Denver Anschutz Medical Campus, Aurora, CO, ⁶Johns Hopkins University, Baltimore, MD, ⁷Hospital For Special Surgery, New York, NY, ⁸Brigham and Women's Hospital & Harvard Medical School, Boston, MA, ⁹Northwestern University, Chicago, IL
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that can significantly impair physical function and quality of life. While physical symptoms such as joint…
Abstract Number: 1228 • ACR Convergence 2025
Transcending barriers to pain care in rural America: a pragmatic comparative effectiveness trial of evidence-based, on-demand, digital behavioral treatments for chronic pain
Brennan Spiegel¹, Jeffrey Curtis², Yashar Eshraghi³, Maged Guirguis³, Beth Darnall⁴, Christine Rini⁵, Emily Holladay⁶, Mehra Muskaan¹, So Yung Choi¹ and Samuel Eberlein¹, ¹Cedars Sinai, Los Angeles, CA, ²Foundation for Advancing Science, Technology, Education and Research, Birmingham, AL, ³University of Queensland Ochsner Medical School, New Orleans, LA, ⁴Stanford University School of Medicine, Palo Alto, CA, ⁵Northwestern University, Chicago, IL, ⁶University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Evidence-based behavioral treatments for chronic pain are largely inaccessible, particularly to rural patients. This decentralized randomized controlled trial compared the effectiveness of two digital,…
Abstract Number: 0813 • ACR Convergence 2025
Impact of Tirzepatide on Musculoskeletal Pain and High-Risk Analgesic Use Among Non-Diabetic Patients with Overweight or Obesity: A Propensity Score-Matched, Active Comparator, New User Study
Gregory Challener¹, Kevin Sheng-Kai Ma², Natalie McCormick³, Minna Kohler⁴, Janeth Yinh³, Chio Yokose⁵, Sharan Rai⁶, Florence Porterfield⁷, Fatima Stanford⁸, Dong Wook Kim⁹, April Jorge³ and Hyon K. Choi¹⁰, ¹Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, ²Center for Global Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States, Philadelphia, PA, ³Massachusetts General Hospital, Boston, MA, ⁴Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Massachusetts General Hospital, Waltham, MA, ⁶Massachusetts General Hospital/Harvard Medical School, Boston, MA, ⁷Division of Endocrinology, Massachusetts General Hospital, Boston, ⁸Neuroendocrine Unit, Pediatric Endocrinology, Massachusetts General Hospital, Boston, ⁹Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital, Boston, ¹⁰MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA
Background/Purpose: Tirzepatide is a dual GIP/GLP-1 receptor co-agonist approved for weight loss in patients with obesity or body mass index (BMI) > 27 kg/m2 with…
Abstract Number: 0320 • ACR Convergence 2025
Transcriptomic profiling of the skeletal muscle of knee OA patients uncovers elevated glucocorticoid and GABA signaling as mediators of skeletal muscle dysfunction in advanced disease
Gina Many¹, Tyler Mansfield², Tyler Sagendorf³, Daniel Evans², Sameneh Farsijani⁴, Bret Goodpaster⁵, Lauren Sparks⁵ and NANCY LANE⁶, ¹Pacific Northwest National Laboratory, Richland, WA, Richland, WA, ²California Pacific Medical Research Institute, San Francisco, CA, ³Pacific Northwest National Laboratory, Richland, WA, ⁴University of Pittsburgh, Pittsburgh, PA, ⁵Translational Research Institute, AventHealth, Orlando, FL, ⁶University of California at Davis, School of Medicine, Sacramento, CA
Background/Purpose: Age-related declines in muscle mass and function are leading causes for hospitalizations and mortality in elderly individuals. The risk of developing knee osteoarthritis also…
Abstract Number: L08 • ACR Convergence 2024
A Phase 2b, Randomized, Double-blind, Placebo-controlled, Dose-ranging and Parallel-group Study to Evaluate the Safety and Efficacy of XG005 in Subjects with Painful Osteoarthritis of the Knee
Limin Ren¹, Wenjie Zheng², Zhenpeng Guan³, Yang Zhang⁴, Zeyu Huang⁵, Tong Li⁶, Yuwei Peng⁷, Qiuli Wu⁸, Wei Gou⁹, Wei Zhao¹⁰, Pengyan Qiao¹¹, Xiaoli Pan¹² and Guang-Liang Jiang¹³, ¹Peking University, People’s Hospital, Rheumatology and Immunology Department, Beijing, China, ²Yantai Yuhuangding Hospital of Qingdao University, Department of Orthopedics, Yantai, China, ³Peking University, Shougang Hospital, Department of Orthopedics, Beijing, China, ⁴Division of Orthopaedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁵West China Hospital of Sichuan University, Department of Orthopedics, Chengdu, China, ⁶Xiangya Hospital of Central South University, Rheumatology and Immunology Department, Changsha, China, ⁷PingXiang People’s Hospital, Rheumatology and Immunology Department, Pingxiang, China, ⁸Tianjin Medical University General Hospital, Department of Orthopedics, Tianjin, China, ⁹Hebei Petrochina Central Hospital, Rheumatology and Immunology Department, Langfang, China, ¹⁰Central Hospital Affiliated to Shenyang Medical College, Department of Orthopedics, Shenyang, China, ¹¹Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Rheumatology and Immunology Department, Taiyuan, China, ¹²Affiliated Hospital of Zunyi Medical University, Rheumatology and Immunology Department, Zunyi, China, ¹³Xgene Pharmaceutical, Lexington, MA
Background/Purpose: Osteoarthritis (OA) affects 595 million people globally; cases are projected to increase 49-95% for various joints by 2050 as populations age (GBD 2023). OA…

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