Abstracts tagged "pain"

Abstract Number: 1274 • 2012 ACR/ARHP Annual Meeting
Relationship Between Morning Stiffness Duration and Severity, Pain Intensity, and Measures of Disease Activity in a 12 Week Efficacy Study of a Modified (Delayed-Release) Prednisone Plus Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis
Frank Buttgereit¹, John R. Kirwan², Kenneth G. Saag³, Reike Alten⁴, Amy Grahn⁵, Patricia Rice⁶ and Maarten Boers⁷, ¹Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Academic Rheumatology Unit, Bristol Royal Infirmary, Bristol, United Kingdom, ³Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, ⁴Charité Univ Medicine, Berlin, Germany, ⁵Clinical Development, Horizon Pharma, Inc, Deerfield, IL, ⁶Statistics, CliniRx Research, Naperville, IL, ⁷Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: RA patients typically present with pain and morning stiffness (MS). MS is predictive of both functional disability and escalated RA care, but the best…
Abstract Number: 1230 • 2012 ACR/ARHP Annual Meeting
The Role of Sleep Problems in Conditioned Pain Modulation in Rheumatoid Arthritis
Yvonne C. Lee¹, Bing Lu², Robert R. Edwards³, Ajay Wasan⁴, Nicholas Nassikas⁵, Daniel J. Clauw⁶, Daniel H. Solomon⁷ and Elizabeth W. Karlson⁸, ¹Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Anesthesiology, Brigham & Womens Hospital, Chestnut Hill, MA, ⁴Anesthesiology, Brigham and Women's Hospital, Chestnut Hill, MA, ⁵Rheumatology, Brigham and Women's Hospital, Boston, MA, ⁶Anesthesiology/Internal Medicine (Rheum), University of Michigan, Ann Arbor, MI, ⁷Division of Rheumatology, Brigham and Women's Hospital, Boston, MA, ⁸Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Among rheumatoid arthritis (RA) patients, pain may exist out of proportion to peripheral inflammation. This observation suggests that central nervous system pain amplification…
Abstract Number: 954 • 2012 ACR/ARHP Annual Meeting
Diagnosis of Secondary Fibromyalgia in an Established Rheumatoid Arthritis Cohort
Yvonne C. Lee¹, Christine K. Iannaccone¹, Michelle A. Frits¹, M. Weinblatt² and Nancy A. Shadick³, ¹Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Rheumatology & Immunology, Brigham & Women's Hospital, Boston, MA, ³Rheumatology/Immunology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: The prevalence of fibromyalgia (FM) is 7-10 times higher among rheumatoid arthritis (RA) patients than the general population. However, the diagnosis of FM in…
Abstract Number: 960 • 2012 ACR/ARHP Annual Meeting
Cyclobenzaprine (CBP) and Its Major Metabolite Norcyclobenzaprine (nCBP) Are Potent Antagonists of Human Serotonin Receptor 2a (5HT2a), Histamine Receptor H-1 and á-Adrenergic Receptors: Mechanistic and Safety Implications for Treating Fibromyalgia Syndrome by Improving Sleep Quality
Bruce Daugherty, Leland Gershell and Seth Lederman, Research and Development, Tonix Pharmaceuticals, Inc., New York, NY
Background/Purpose: Bedtime cyclobenzaprine (CBP) improves fibromyalgia symptoms (pain, fatigue, tenderness, and mood) and improves sleep quality (decreases Cyclic Alternating Pattern Type A2 + A3) (1).…
Abstract Number: 744 • 2012 ACR/ARHP Annual Meeting
Racial Differences in Reported Knee Pain Severity Persist Even After Adjustment for Knee Examination and Radiographic Findings: Data From the Osteoarthritis Initiative
Paige Luneburg¹, Laura Yerges-Armstrong², Braxton D. Mitchell² and Marc C. Hochberg¹, ¹Department of Medicine, University of Maryland, Baltimore, MD, ²Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: African Americans have a higher prevalence of both radiographic and symptomatic radiographic knee osteoarthritis (OA) than Caucasians. In addition, African Americans with knee OA…
Abstract Number: 558 • 2012 ACR/ARHP Annual Meeting
Rapid Improvements in Patient Reported Outcomes with Certolizumab Pegol in Patients with Axial Spondyloarthritis, Including Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis: 24 Week Results of a Phase 3 Double Blind Randomized Placebo-Controlled Study
Joachim Sieper¹, Alan J. Kivitz², A.M. Van Tubergen³, Atul A. Deodhar⁴, Geoffroy Coteur⁵, Franz Woltering⁶ and Robert B. M. Landewé⁷, ¹Medical Department I, Rheumatology, Charité University Medicine, Berlin, Germany, ²Altoona Center for Clinical Research, Duncansville, PA, ³Department of Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Oregon Health & Science University, Portland, OR, ⁵UCB Pharma, Brussels, Belgium, ⁶UCB Pharma, Monheim, Germany, ⁷Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands
Background/Purpose: Axial spondyloarthritis (axSpA) is a form of spondyloarthritis (SpA) that includes both ankylosing spondylitis (AS) and non-radiographic axial SpA (nr-axSpA), as defined by the…
Abstract Number: 339 • 2012 ACR/ARHP Annual Meeting
Differences Between Juvenile and Adult Rodents with Collagen Induced Arthritis
Tracy D. Wilson-Gerwing¹, Isaac V. Pratt², David M.L. Cooper², Tawni I. Silver³ and Alan M. Rosenberg⁴, ¹Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ²Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada, ³Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada, ⁴Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada
Background/Purpose: Juvenile idiopathic arthritis (JIA) is among the most common chronic diseases of childhood. Arthritis is a potentially disabling disease that can result in ongoing…
Abstract Number: 343 • 2012 ACR/ARHP Annual Meeting
Functional Impairment in an Animal Model for Rheumatoid Arthritis Assessed As Changes in Gait Is Due to Joint Destruction but Not Synovial Inflammation Per Se
Gregor Bauer¹, Constantin Aschauer¹, Birgit Niederreiter², Josef S. Smolen³, Kurt Redlich² and Silvia Hayer², ¹Dep. of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Department of Internal Medicine III,, Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Background/Purpose: To investigate the individual impact of synovial inflammation, subchondral bone erosion or cartilage damage on functional impairment in an animal model of Rheumatoid Arthritis…
Abstract Number: 2448 • 2012 ACR/ARHP Annual Meeting
Sustained Improvement Physical Function Following an Integrated Rehabilitation Programme for Chronic Knee Pain
Mike Hurley¹ and Dr Nicola E. Walsh², ¹School of Rehabilitation Sciences, St George's University of London, London, United Kingdom, ²Allied Health Professions, University of the West of England Bristol, Bristol, United Kingdom
Background/Purpose: Chronic knee pain causes personal suffering and impairs physical function and quality of life. Usual primary care involves prolonged drug therapy in spite of…
Abstract Number: 95 • 2012 ACR/ARHP Annual Meeting
Smoking Is Associated with Worse and More Widespread Pain, Worse Disease Activity, Function, Fatigue and Health Related Quality of Life in Patients with Axial Spondyloarthritis –Results From a Population Based Cohort
Ann B. I. Bremander¹, Ingemar F. Petersson², Emma Haglund³, Stefan Bergman⁴ and Lennart TH Jacobsson⁵, ¹Department of Exercise Physiology, Biomechanics and Health, Halmstad University School of Business and Engineering, Halmstad, Sweden, ²Lund University, Lund, Sweden, ³Research and Development Centre, Spenshult Hospital for Rheumatic Diseases, Halmstad, Sweden, ⁴Spenshult Research and Development Center, Halmstad, Sweden, ⁵Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Background/Purpose: In subjects with early axial Spondyloarthritis (SpA) smoking has recently been associated with earlier onset of disease, worse lesions of the sacroiliac joints and…
Abstract Number: 2436 • 2012 ACR/ARHP Annual Meeting
Clinical Effectiveness and Costs of an Integrated Rehabilitation Programme Compared with Outpatient Physiotherapy for Chronic Knee Pain
Mike Hurley¹, Dr Nicola E. Walsh² and Sally Jessep³, ¹School of Rehabilitation Sciences, St George's University of London, London, United Kingdom, ²Allied Health Professions, University of the West of England Bristol, Bristol, United Kingdom, ³Physiotherapy Out-Patients Department, Kent, United Kingdom
Background/Purpose: Chronic knee pain is a major cause of disability. Management guidelines recommend exercise and self-management interventions. We previously described a rehabilitation programme that integrates…
Abstract Number: 1867 • 2012 ACR/ARHP Annual Meeting
Assessment of ART Therapy Program for Women with Fibromyalgia: Randomized, Controlled, Blinded Study
Andreia S. Baptista¹, Anamaria Jones¹, Fernanda P. Cardoso¹, Betina C. Schaffir¹, Elisa R. W. Coelho¹, Aline Orlandi¹ and Jamil Natour², ¹Unifesp-EPM, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ²Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: Fibromyalgia (FM) is a chronic non-inflammatory syndrome characterized by diffuse pain throughout the body, sleep disorder, stiffness, fatigue, depression and other psychological problems. Patients…
Abstract Number: 2632 • 2012 ACR/ARHP Annual Meeting
Doing Is Believing: Health Beliefs Before and After an Exercised-Based Rehabilitation Programme for Chronic Knee Pain
Mike Hurley¹ and Dr Nicola E. Walsh², ¹School of Rehabilitation Sciences, St George's University of London, London, United Kingdom, ²Allied Health Professions, University of the West of England Bristol, Bristol, United Kingdom
Background/Purpose: An integrated exercise-based rehabilitation programme, Enabling Self-management and Coping with Arthritis knee Pain through Exercise (ESCAPE-knee pain), improves pain and physical disability of people…
Abstract Number: 1828 • 2012 ACR/ARHP Annual Meeting
Smoking Is Associated with Worse and More Widespread Pain, Worse Fatigue, General Health and Quality of Life in a Swedish Population Based Cohort of Patients with Psoriatic Arthritis
Ann B. I. Bremander¹, Lennart TH Jacobsson², Stefan Bergman³, Emma Haglund⁴ and Ingemar F. Petersson⁵, ¹Department of Exercise Physiology, Biomechanics and Health, Halmstad University School of Business and Engineering, Halmstad, Sweden, ²Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ³Spenshult Research and Development Center, Halmstad, Sweden, ⁴Research and Development Centre, Spenshult Hospital for Rheumatic Diseases, Halmstad, Sweden, ⁵Lund University, Lund, Sweden
Background/Purpose: Smoking has been found to be associated with an increased risk of developing psoriatic arthritis (PsA). The purpose of this study was analyse possible…
Abstract Number: 1582 • 2012 ACR/ARHP Annual Meeting
Long Term Costs and Cost-Effectiveness of an Integrated Rehabilitation Programme for Chronic Knee Pain
Mike Hurley¹ and Dr Nicola E. Walsh², ¹School of Rehabilitation Sciences, St George's University of London, London, United Kingdom, ²Allied Health Professions, University of the West of England Bristol, Bristol, United Kingdom
Background/Purpose: Management of chronic knee pain incurs enormous direct and indirect healthcare costs. Enabling Self-management and Coping with Arthritic knee Pain through Exercise (ESCAPE-knee pain)…

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