Abstracts tagged "PAD and citrullination"

Abstract Number: 1004 • 2018 ACR/ARHP Annual Meeting
Reevaluating Citrullination and Peptidylarginine Deiminases in Neutrophil Extracellular Trap-like Structures
Caitlyn L. Holmes¹, Daeun Shim², John Kernien¹, Chad J. Johnson¹, Jeniel E. Nett³ and Miriam A. Shelef^4,5, ¹University of Wisconsin - Madison, Madison, WI, ²Medicine, University of Wisconsin - Madison, Madison, WI, ³Medicine and Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI, ⁴Department of Medicine, Division of Rheumatology, University of Wisconsin - Madison, Madison, WI, ⁵William S. Middleton Memorial Veterans Hospital, Madison, WI
Background/Purpose: Neutrophil extracellular traps (NETs) are webs of chromatin and proteins extruded from neutrophils during NETosis. NETs are increased and display citrullinated proteins that are…
Abstract Number: 488 • 2017 ACR/ARHP Annual Meeting
Increased Expression of TNF-α and PAD-2 in Human Monocytes Following Treatment with Protein Modified with Malondialdehyde-Acetaldehyde (MAA) and Citrulline
Logan M. Duryee¹, Michael J. Duryee², Dahn L Clemens¹, Evan M. Ryan¹, Carlos D. Hunter², Lynell W. Klassen³, James R. O'Dell³, Daniel R. Anderson¹, Ted R. Mikuls⁴ and Geoffrey M. Thiele¹, ¹University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁴Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: We have previously shown that malondialdehyde-acetaldehyde (MAA) and citrullinated proteins are present together in the synovial tissues of rheumatoid arthritis (RA) patients. Macrophage are…
Abstract Number: 2183 • 2014 ACR/ARHP Annual Meeting
Release of Enzymatically Active Peptidyl Arginine Deiminases (PADs) By Neutrophils Allows Generation of Citrullinated Extracellular Autoantigens in the Synovial Fluid of Patients with Rheumatoid Arthritis
Julia Spengler¹, Bozo Lugonja², Andrew Creese¹, Jimmy Ytterberg³, Karin Lundberg⁴, Michael Milward¹, Mark Pearson⁵, Christopher Buckley⁶, Andrew Filer¹, Karim Raza⁷, Paul Cooper¹, Iain Chapple⁸ and Dagmar Scheel-Toellner¹, ¹University of Birmingham, Birmingham, United Kingdom, ²Rheumatology Research Group, University of Birmingham Research Laboratories, University of Birmingham, Birmingham, United Kingdom, ³Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁵University of Birmihgham, Birmingham, United Kingdom, ⁶Rheumathology Research Group, University of Birmingham, Birmingham, United Kingdom, ⁷Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom, ⁸Periodontology Dept, School of Dentistry, University of Birmingham, Birmingham, United Kingdom
Background/Purpose Citrullinated proteins are important autoantigens in the inflamed joints of patients with rheumatoid arthritis (RA). Several of these proteins are derived from proteins generally…
Abstract Number: 1201 • 2014 ACR/ARHP Annual Meeting
Hypoxia Modulates Peptidyl Arginine Deiminase 4 Activity and Neutrophil Extracellular Trap Formation
Akif A. Khawaja^1,2, Charis Pericleous¹, Luke W. Thomas³, Margaret Ashcroft³, Joanna C. Porter² and Ian Giles¹, ¹Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ²Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, ³Centre for Cell Signalling and Molecular Genetics, Centre for Cell Signalling and Molecular Genetics, University College London, London, United Kingdom
Background/Purpose RA is an autoimmune rheumatic disease characterised by ACPA, endothelial dysfunction, platelet activation, synovial hyperplasia and hypoxia in affected joints. ACPA recognise citrullinated proteins,…

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