Abstracts tagged "outcome measures and psoriatic arthritis"

Abstract Number: 641 • 2018 ACR/ARHP Annual Meeting
Construct Validity of the Swollen and Tender Joint Counts for the Measurement of MSK Disease Activity in Psoriatic Arthritis
Ali Duarte-Garcia¹, Lihi Eder², Alisa Stephens-Shields³, Niti Goel⁴, Maarten de Wit⁵, Dafna D Gladman⁶, Oliver FitzGerald⁷, Philip Helliwell⁸, Ying Ying Leung⁹, Philip J. Mease¹⁰, Ana-Maria Orbai¹¹, Beverly Shea¹², Vibeke Strand¹³, William Tillett¹⁴, Laura C. Coates¹⁵ and Alexis Ogdie¹⁶, ¹Mayo Clinic College of Medicine and Science, Rochester, MN, ²Women's College Research Institute, University of Toronto, Women's College Hospital, Toronto, ON, Canada, ³Department of Biostatistics, University of Pennsylvania, Philadelphia, PA, ⁴Kezar Life Sciences; Duke University School of Medicine, Durham, NC, ⁵EULAR standing committee of PARE, Zurich, Switzerland, ⁶Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ⁷Department of Rheumatology, St Vincent's University Hospital and Conway Institute, University College Dublin, Ireland, Dublin, Ireland, ⁸LIMM, Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, ⁹North District Hospital, Hong Kong, China, ¹⁰Swedish Medical Center and University of Washington School of Medicine, Seattle, WA, ¹¹Johns Hopkins University School of Medicine, Baltimore, MD, ¹²University of Ottawa, Ottawa, ON, Canada, ¹³Stanford University School of Medicine, Palo Alto, CA, ¹⁴Royal National Hospital for Rheumatic Diseases and University of Bath, Bath, United Kingdom, ¹⁵University of Oxford, Oxford, United Kingdom, ¹⁶Medicine/Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Joint counts are central to the measurement of musculoskeletal disease activity in psoriatic arthritis (PsA). Few studies have addressed whether the three most commonly…
Abstract Number: 650 • 2018 ACR/ARHP Annual Meeting
Can Disease Activity in Patients with Psoriatic Arthritis be Adequately Assessed By a Modified Disease Activity Index for Psoriatic Arthritis (DAPSA) Based on 28 Joints?
Brigitte Michelsen^1,2, Joseph Sexton¹, Josef S. Smolen³, Daniel Aletaha⁴, Niels Steen Krogh⁵, Désirée van der Heijde⁶, Tore Kvien⁷ and Merete Lund Hetland^8,9, ¹Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Division of Rheumatology, Department of Internal Medicine, Hospital of Southern Norway Trust, Kristiansand, Norway, ³Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, ⁴Medical University of Vienna, Vienna, Austria, ⁵ZiteLab ApS, Copenhagen, Denmark, ⁶Leiden University Medical Centre, Leiden, Netherlands, ⁷Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁸Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, The DANBIO Registry, Glostrup, Denmark, ⁹University of Copenhagen, Copenhagen, Denmark
Background/Purpose: Many registries routinely collect only 28 joint count, although 66/68 joint count has higher face validity in PsA. We aimed to compute and test…
Abstract Number: 1406 • 2018 ACR/ARHP Annual Meeting
Longitudinal Construct Validity of the Psaid Individual Items: Can We Eliminate Other Questionnaires If Using the Psaid?
Jessica Walsh¹, Jose U. Scher², Soumya M. Reddy³, M. Elaine Husni⁴ and Alexis Ogdie⁵, ¹University of Utah School of Medicine, Salt Lake City, UT, USA, Salt Lake City, UT, ²New York University School of Medicine, New York, NY, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, ⁵Medicine/Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: The Psoriatic Arthritis Impact of Disease (PsAID) questionnaire is a patient reported measure of disease impact. The 12-item questionnaire has many advantages including demonstrated…
Abstract Number: 1606 • 2018 ACR/ARHP Annual Meeting
The 66/68 Joint Count for the Measurement of MSK Disease Activity/Peripheral Joint Activity in Psa: A Grappa-Omeract Working Group Initiative
Ali Duarte-Garcia¹, Lihi Eder², Niti Goel³, Robin Christensen⁴, Maarten de Wit⁵, Oliver FitzGerald⁶, Dafna D Gladman⁷, Richard Holland⁸, Ying Ying Leung⁹, Christine Lindsay¹⁰, Neil McHugh¹¹, Philip J. Mease¹², Ana-Maria Orbai¹³, Beverly Shea¹⁴, Vibeke Strand¹⁵, William Tillett¹⁶, Laura C. Coates¹⁷ and Alexis Ogdie¹⁸, ¹Mayo Clinic College of Medicine and Science, Rochester, MN, ²Women's College Research Institute, University of Toronto, Women's College Hospital, Toronto, ON, Canada, ³Kezar Life Sciences; Duke University School of Medicine, Durham, NC, ⁴Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg, Denmark, ⁵EULAR standing committee of PARE, Zurich, Switzerland, ⁶Department of Rheumatology, St Vincent's University Hospital and Conway Institute, University College Dublin, Ireland, Dublin, Ireland, ⁷University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁸Royal Prince Alfred Hospital Medical Centre, Sydney, Australia, ⁹North District Hospital, Hong Kong, China, ¹⁰Medical Affairs, Amgen Inc, Thousand Oaks, CA, ¹¹Rheumatology, Royal National Hospital, Bath, Great Britain, ¹²Swedish Medical Center and University of Washington School of Medicine, Seattle, WA, ¹³Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁴University of Ottawa, Ottawa, ON, Canada, ¹⁵Stanford University School of Medicine, Palo Alto, CA, ¹⁶Royal National Hospital for Rheumatic Diseases and University of Bath, Bath, United Kingdom, ¹⁷University of Oxford, Oxford, United Kingdom, ¹⁸Medicine/Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: A psoriatic arthritis (PsA) core domain set to be measured in randomized controlled trials (RCT) and longitudinal observational studies (LOS) was developed by Group…
Abstract Number: 1805 • 2017 ACR/ARHP Annual Meeting
Construct Validity of RAPID3 for Measurement of Disease Activity in Psoriatic Arthritis
Jessica A. Walsh¹, Christine Willinger², M. Elaine Husni³, Soumya M. Reddy⁴, Jose U. Scher⁵ and Alexis Ogdie⁶, ¹Division of Rheumatology, University of Utah, Salt Lake City, UT, ²University of Pennsylvania, Philadelphia, PA, ³Cleveland Clinic, Cleveland, OH, ⁴Department of Medicine, Division of Rheumatology *contributed equally, New York University School of Medicine, New York, NY, ⁵New York University School of Medicine, New York, NY, ⁶Medicine/Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: The Routine Assessment of Patient Index Data (RAPID3) was developed and validated for rheumatoid arthritis (RA). Little data exist on the use of RAPID3…
Abstract Number: 2039 • 2017 ACR/ARHP Annual Meeting
Validity of the Wpai-SHP in Psoriatic Arthritis and Estimation of the Minimally Important Difference
William Tillett^1,2, Gavin Shaddick³, Bashaar Boyce⁴ and Neil J. McHugh⁵, ¹Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ²Royal National Hospital for Rheumatic Diseases and University of Bath, Bath, United Kingdom, ³Centre for Data Science and Statistics, University of Exeter, Bath, United Kingdom, ⁴Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ⁵Royal National Hospital for Rheumatic Diseases, Bath, UK, Bath, United Kingdom
Background/Purpose: Participation, including work disability, is an important patient centred outcome and is in the middle ring of the Outcome Measures in Rheumatology (OMERACT) psoriatic…
Abstract Number: 2245 • 2017 ACR/ARHP Annual Meeting
The Effects of Structural Damage on Functional Disability in Psoriatic Arthritis
Andreas Kerschbaumer¹, Gabriela Supp¹, Josef S. Smolen^1,2 and Daniel Aletaha¹, ¹Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, ²2nd Department of Medicine, Hietzing Hospital, Vienna, Austria
Background/Purpose: Functional outcomes are central in patients with chronic inflammatory musculoskeletal diseases. In a secondary data analysis of the GO-REVEAL trial we investigated if structural…
Abstract Number: 2971 • 2017 ACR/ARHP Annual Meeting
What Do Reduced 28 Joint Counts Miss in Patients with Psoriatic Arthritis?
Andreas Kerschbaumer¹, Josef S. Smolen^1,2 and Daniel Aletaha¹, ¹Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, ²2nd Department of Medicine, Hietzing Hospital, Vienna, Austria
Background/Purpose: Clinical joint assessment by the rheumatologist is a key examination of patients with psoriatic arthritis (PSA). A clinically swollen joint is predicting subsequent joint…
Abstract Number: 2742 • 2016 ACR/ARHP Annual Meeting
How Are Enthesitis, Dactylitis and Nail Involvement Measured and Reported in Recent Clinical Trials of Psoriatic Arthritis (PsA)? a Systematic Literature Review
Sofia Ramiro¹, Josef Smolen², RBM Landewé³, Désirée van der Heijde⁴ and Laure Gossec⁵, ¹Leiden University Medical Center, Leiden, Netherlands, ²Internal Medicine III, Div. of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Paris 06 University and AP-HP, Hôpital Pitié Salpêtrière, Paris, France
Background/Purpose: Enthesitis, dactylitis and nail involvement are part of the core set of domains to be reported in trials of PsA. However, no specific instruments…
Abstract Number: 549 • 2014 ACR/ARHP Annual Meeting
Reliability and Construct Validity of the Psoriasis Symptom Inventory in Subjects with Psoriatic Arthritis
Philip J. Mease¹, Mark C. Genovese², Alex Mutebi³, Hilary Wilson⁴, Dennis Revicki⁴, Ngozi Erondu⁵, Ajay Nirula⁵, JingYuan Feng⁵ and Hema Viswanathan⁶, ¹Swedish Medical Center and University of Washington, Seattle, WA, ²Division of Rheumatology, Stanford University Medical Center, Palo Alto, CA, ³Global Health Economics, Amgen Inc, Thousand Oaks, CA, ⁴Outcomes Research, Evidera, Bethesda, MD, ⁵Amgen Inc, Thousand Oaks, CA, ⁶Amgen Inc, Amgen Inc, Thousand Oaks, CA
Background/Purpose: The Psoriasis Symptom Inventory (PSI) is an 8-item patient-reported outcome measure of psoriasis symptom severity. Data from a Phase 2 study of Brodalumab in…
Abstract Number: 347 • 2013 ACR/ARHP Annual Meeting
Factors Explaining The Discrepancy Between Patient and Physician Global Assessment Of Disease Activity In Psoriatic Arthritis
Lihi Eder¹, Arane Thavaneswaran¹, Vinod Chandran², Richard J. Cook³ and Dafna D. Gladman², ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada
Background/Purpose: Patients and physicians often perceive the extent of disease activity differently. We aimed to assess the factors contributing to the variability in scoring of…
Abstract Number: 1833 • 2012 ACR/ARHP Annual Meeting
Healthcare Costs in Psoriatic Arthritis Patients Newly Initiated On a Biologic Disease-Modifying Anti-Rheumatic Drug or Methotrexate
Frank Zhang¹, Robert Hiscock² and Jeffrey R. Curtis³, ¹Pricing and Market Access, I&I, Celgene Corporation, Warren, NJ, ²Analysis Group, Inc., Montreal, QC, Canada, ³Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Several treatment options are available for psoriatic arthritis (PsA) patients (pts). The healthcare cost associated with the management of PsA pts varies depending on…
Abstract Number: 535 • 2012 ACR/ARHP Annual Meeting
Reduced Joint Counts Misclassify Psoriatic Arthritis Patients with Oligoarthritis and Miss Significant Active Disease
Laura C. Coates¹, Oliver FitzGerald², Dafna D. Gladman³, Neil J. McHugh⁴, Philip J. Mease⁵, Vibeke Strand⁶, Philip S. Helliwell⁷ and GRAPPA Composite Exercise (GRACE) collaboration⁸, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Dept of Rheumatology, St. Vincent's Univ Hospital, Dublin, Ireland, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ⁵Rheumatology Research, Swedish Medical Center, Seattle, WA, ⁶Adjunct, Division of Immunology / Rheumatology, Stanford University, Portola Valley, CA, ⁷PsAID taskforce, EULAR, Zurich, Switzerland, ⁸Leeds
Background/Purpose: Despite recommendations to use full joint counts to assess patients with PsA, reduced joint counts designed for RA are often used for reporting outcomes…

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