Abstracts tagged "osteoporosis"

Abstract Number: 1325 • ACR Convergence 2021
Osteoporosis in Psoriatic Arthritis
Sara M. Rojas Herrera¹, Ignacio Braña Abascal¹, Maria Priego Fernanddez-Martos¹, Delia Fernandez Lozano¹, Lara M. Chaves Chaparro¹, Raul Veroz Gonzalez¹, Juan J. Aznar Sanchez² and Eugenio Chamizo Carmona¹, ¹Hospital de Mérida, Mérida, Spain, ²Hospital de Mérida, Merida, Spain
Background/Purpose: Osteoporosis (OP) is a frequently underestimated comorbidity in immune-mediated inflammatory diseases (IMIDs). Its association with IMIDs is worse characterized in Psoriatic Arthritis (PsA) than…
Abstract Number: 0445 • ACR Convergence 2021
Safety and Efficacy of Denosumab vs Risedronate in Patients with Glucocorticoid-Induced Osteoporosis and Rheumatoid Arthritis
Jonathan Adachi¹, Arkadi Chines², Shuang Huang², Kenneth Saag³, Willem Lems⁴ and Piet Geusens⁵, ¹McMaster University/St. Joseph's Healthcare, Hamilton, ON, Canada, ²Amgen Inc., Thousand Oaks, CA, ³University of Alabama at Birmingham, Birmingham, AL, ⁴VUmc, Amsterdam, Netherlands, ⁵Maastricht University, Genk, Belgium
Background/Purpose: Denosumab (DMAb) is approved for the treatment of glucocorticoid (GC)–induced osteoporosis (GiOP). In a phase 3, international, active-controlled, double-blind, double-dummy study, treatment with DMAb…
Abstract Number: 0446 • ACR Convergence 2021
Clinical Characteristics, Including History of Myocardial Infarction and Stroke, Among US PMO Women Initiating Treatment with Romosozumab and Other Anti-osteoporosis Therapies
Jay Lin¹, Carrie Nielson¹, Mary Oates¹, Cynthia Deignan² and Zhigang Yu¹, ¹Amgen Inc., Thousand Oaks, CA, ²Amgen, Inc., Agoura Hills, CA
Background/Purpose: This study is an ongoing USFDA post-marketing requirement (2020-2024) to assess the impact of boxed warning on romosozumab (romo) treatment and the feasibility of…
Abstract Number: 0447 • ACR Convergence 2021
Bone Anabolic Effects of a Novel Orally-Available Small Molecule SIK2/SIK3 Inhibitor
Cheng-Chia Tang¹, Shiv Verma¹, Steve De Vos², David Amantini³, Philippe Clement-Lacroix³, Nicolas Desroy³, Antonio Speziale⁴, Daniel Brooks⁵, Mary Bouxsein⁵, Janaina da Silva Martins¹, Yingshe Zhao⁶, Henry Kronenberg¹ and Marc Wein¹, ¹MGH Endocrine Unit, Boston, MA, ²Galapagos NV, Mechelen, Belgium, ³Galapagos SASU, Romainville, France, ⁴Galapagos GmbH, Basel, Switzerland, ⁵Beth Israel Deaconess Medical Center, Boston, MA, ⁶MGH Endocrine Unnit, Boston, MA
Background/Purpose: Orally-available bone anabolic agents represent a major unmet medical need for patients with osteoporosis. Widespread use of parathyroid hormone (PTH)-based osteo-anabolic therapies is limited…
Abstract Number: 0448 • ACR Convergence 2021
Bone Microarchitecture Assessed by 3D High-resolution Peripheral Quantitative Computed Tomography (HR-pQCT) as Predictor of Incident Fracture in Rheumatic Disease Patients on Long-term Glucocorticoid- a Five-year Longitudinal Study
ho SO¹, Xerox Lau¹, Vivian Hung¹, Steve Pang², Shirley Ying³, Kitty Kwok⁴, Ka Lai Lee⁵, Jolly Lee⁶, Jack Lee¹, James Griffith¹, Ling Qin¹ and Lai-Shan Tam⁷, ¹The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Kwong Wah Hospital, Hong Kong, Hong Kong, ³Prince Margaret Hospital, Hong Kong, Hong Kong, ⁴Queen Elizabeth Hospital, Hong Kong, Hong Kong, ⁵Pamela Youde Nethersole Eastern Hospital, Hong Kong, Hong Kong, ⁶Tai Po Hospital, Hong Kong, Hong Kong, ⁷Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China (People's Republic)
Background/Purpose: Impaired bone quality and strength estimated by high resolution peripheral quantitative computer tomography (HR-pQCT) in patients with rheumatic diseases on long-term glucocorticoid (LTGC) therapy…
Abstract Number: 0653 • ACR Convergence 2021
Adherence to the 2015 ACR Guidelines for the Management of Polymyalgia Rheumatica and Screening for Osteoporosis at a Tertiary Care Medical Center
Padmini Parameswaran¹ and Michael Lucke², ¹Allegheny Health Network Medical Education Consortium, Pittsburgh, PA, ²Allegheny Health Network, Pittsburgh, PA
Background/Purpose: Since the first description of polymyalgia rheumatica (PMR) in the early 1950s, the ideal dose and duration of glucocorticoid therapy has varied. In 2015,…
Abstract Number: 1135 • ACR Convergence 2021
Osteoporosis Assessment and Outcomes in Candidates for Liver Transplantation in a Tertiary Center
Cristina Rodríguez-Alvear¹, MARIANO ANDRES¹, Maria-Luisa Peral-Garrido², Irene Calabuig³, Ernesto Tovar-Sugrañes¹, Mari-Carmen López-González¹, Pilar Bernabeu¹, Agustín Martínez-Sanchis¹, Ximo Esteve¹, Paloma Vela¹, Cayetano Miralles¹ and Maria Vega Jovani Casano⁴, ¹Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain, ²Hospital General Universitario de Alicante-ISABIAL, Novelda, Spain, ³Hospital General Universitario de Alicante, Alicante, Spain, ⁴National Health system, Alicante, Spain
Background/Purpose: A rapid loss of bone mass and an increase in fractures have been described in the first six months after liver transplantation. This phenomenon…
Abstract Number: 1137 • ACR Convergence 2021
REMS Technology for the Assessment of Bone Health in a Male Population
Delia Ciardo¹, Paola Pisani¹, Fiorella Anna Lombardi¹, Marco Di Paola¹, Roberto Franchini¹, Maurizio Muratore², Francesco Conversano¹ and Sergio Casciaro¹, ¹National Research Council, Institute of Clinical Physiology, Lecce, Italy, Lecce, Italy, ²Vito Fazzi Hospital, ASL-LE, O.U. of Rheumatology, Lecce, Italy, Lecce, Italy
Background/Purpose: This study aimed to evaluate the diagnostic accuracy of the ultrasound-based densitometric technology called Radiofrequency Echographic Multi Spectrometry (REMS) in the diagnosis of osteoporosis…
Abstract Number: 1138 • ACR Convergence 2021
Assessing Trends in Dual Energy X-Ray Absorptiometry (DXA) Utilization Among Medical Providers in the United States
Timothy Edgil¹, Kenneth Saag², Jeffrey Curtis³ and Maria I. Danila², ¹Division of General Internal Medicine, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The twenty first century has seen falling reimbursement rates for dual energy X-ray absorptiometry (DXA) testing coupled with a rising elderly population in the…
Abstract Number: 1139 • ACR Convergence 2021
Fracture Liaison Service Outcomes at a Southern California County Hospital Highlights Need for Health System Improvements
Muntarin Karim¹, lorien ahn², Jordan Thompson¹, Christina Downey³, Lorena Salto⁴ and Karina Torralba⁵, ¹Loma Linda University, Redlands, CA, ²loma linda university medical center, Loma Linda, CA, ³Loma Linda University Medical Center, Redlands, CA, ⁴Loma Linda University Health, Loma Linda, CA, ⁵Division of Rheumatology, Department of Medicine, Loma Linda University Healthcare, Loma Linda, CA
Background/Purpose: Osteoporosis causes significant morbidity and mortality in the elderly. Despite the benefits of treatment, < 25% of elderly patients who fracture receive treatment. A…
Abstract Number: 1140 • ACR Convergence 2021
Fracture Risk in DXA-Appropriate Patients on Glucocorticoids: Is Everyone Tested According to Screening Guidelines?
Alexandra Chop¹, Rajesh Kupuraju¹, Ruchi Patel¹, Kristen Salava¹, Madhuri Duggirala¹, Aparna Baburaj¹, Andrea Berger², Jason Brown¹ and David Bulbin³, ¹Geisinger Medical Center, Danville, PA, ²Department of Population Health Sciences, Geisinger Medical Center, Danville, PA, ³Geisinger Health System, Danville, PA
Background/Purpose: Glucocorticoids are commonly prescribed for a multitude of indications, yet have many side effects, one of which is glucocorticoid induced osteoporosis (GIOP). The 2017…
Abstract Number: 1141 • ACR Convergence 2021
Factors Associated with Fragility Fracture in Patients with Systemic Mastocytosis: Data from an Inception Cohort in a Single Centre
Karen Carpio Astudillo¹, Filip Skrabski², ISABEL CASTREJON³, Jose Maria Alvaro-Gracia², Alicia Garcia Prieto² and Teresa González⁴, ¹Hospital General Universitario Gregorio Maraon, Madrid, Spain, ²Hospital General Universitario Gregorio Marañón, Madrid, Spain, ³Pfizer Spain, Chicago, ⁴H Gregorio Maraon, Madrid, Spain
Background/Purpose: Systemic Mastocytosis (SM) is a very rare disease (0,5 -1 per 10000 in adults). Most common manifestations are skin related or anaphylaxis, however almost…
Abstract Number: 1143 • ACR Convergence 2021
Predictors of Engagement in Bone Health Care Among Rural Veterans at Risk for Osteoporosis
Karla Miller¹, Kimberly McCoy², Christopher Richards², Aaron Seaman³ and Samantha Solimeo⁴, ¹Department of Internal Medicine, Rheumatology Section, Veterans Affairs Salt Lake City Health Care System; Division of Rheumatology, University of Utah School of Medicine, Salt Lake City, UT, ²VA Office of Rural Health, Veterans Rural Health Resource Center-Iowa City; Comprehensive Access & Delivery Research and Evaluation, Department of Veterans Affairs, CADRE, Iowa City VA HCS, Iowa City, IA, ³VA Office of Rural Health, Veterans Rural Health Resource Center-Iowa City (VRHRC-IC); Division of Genera l Internal Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, ⁴VA Office of Rural Health, Veterans Rural Health Resource Center-Iowa City; Comprehensive Access & Delivery Research and Evaluation; and Primary Care Analytics Team Iowa City (PCAT-IC), Department of Veterans Affairs, CADRE, Iowa City VA HCS Division of General Internal Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: A virtual bone health team (BHT) model was implemented to identify, screen, and treat rural Veterans at risk for osteoporosis. This study was conducted…
Abstract Number: 1145 • ACR Convergence 2021
Prevalence of and Risk Factors for Vertebral Fractures and Low Bone Mass Density Among Women Aging with HIV in Peru
Diego Cabrera¹, Mijahil P. Cornejo², Rebecca Slotkin³, Yvett Pinedo⁴, Wei Yu⁵, Wenmin Guan⁵, Patricia J. Garcia⁶ and Evelyn Hsieh⁷, ¹Yale School of Medicine, Lima, Peru, ²Grunenthal peruana, Lima, Peru, ³Yale New Haven Hospital, New Haven, CT, ⁴Hospital Nacional Arzobispo Loayza, Lima, Peru, ⁵Department of Radiology, Chinese Academy of Medicine Sciences and Peking Union Medical College Hospital, Beijing, China (People's Republic), ⁶Universidad Peruana Cayetano Heredia, Lima, Peru, ⁷Yale School of Medicine, New Haven, CT
Background/Purpose: Few studies in Latin America and the Caribbean have evaluated osteoporosis and fracture epidemiology among populations at increased risk for secondary osteoporosis, such as…
Abstract Number: 0117 • ACR Convergence 2020
Development of an In Vitro Trabecular Human Bone Model to Recapitulate Features of Glucocorticoid-induced Osteoporosis
Annemarie Lang¹, Karoline Diesing¹, Alexandra Damerau¹, Moritz Pfeiffenberger¹, Timo Gaber¹ and Frank Buttgereit², ¹Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, ²Charité University Medicine, Berlin, Germany
Background/Purpose: The bone matrix consists of inorganic and organic components and a variety of specialized cells such as osteoblasts, osteocytes and osteoclasts. The bone-forming osteoblasts…

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