ACR Meeting Abstracts

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Abstracts tagged "osteoporosis and treatment"

  • Abstract Number: 1039 • 2018 ACR/ARHP Annual Meeting

    Tenofovir Induces Osteopenia and Dipyridamole, an Inhibitor of the Ent-1 Nucleoside Transporter, Reverses the Osteopenic Effect of Tenofovir In Vivo

    Francisco Miguel Conesa-Buendia1, Patricia Llamas2, Tuere Wilder3, Raquel Largo4, Gabriel Herrero-Beaumont4, Bruce N. Cronstein5 and Aranzazu Mediero6, 1Bone and Joint Research Unit, IIS-Fundacion Jimenez Diaz- UAM, Madrid, Spain, 2Bone and Joint Research Unit, IIS-Fundacion Jimenez Díaz-UAM, Madrid, Spain, 3Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 4Bone and Joint Research Unit, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, 5Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY, 6Joint and Bone Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain

    Background/Purpose: Osteopenia and fragility fractures have been associated with HIV infection. Tenofovir, one of the most commonly used antivirals in HIV, also leads to increases…
  • Abstract Number: 2808 • 2018 ACR/ARHP Annual Meeting

    T-Score As an Indicator of Fracture Risk on Therapy: Evidence from Romosozumab Vs Alendronate Treatment in the Active-Controlled Fracture Study in Postmenopausal Women with Osteoporosis at High Risk Trial

    Felicia Cosman1, E. Michael Lewiecki2, Peter R Ebeling3, Eric Hesse4, Nicola Napoli5, Daria B Crittenden6, Maria Rojeski6, Wenjing Yang6, Cesar Libanati7 and Serge Ferrari8, 1Columbia University, New York, NY, 2New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, 3Monash University, Melbourne, Australia, 4University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 5Campus Bio-Medico University of Rome, Rome, Italy, 6Amgen Inc., Thousand Oaks, CA, 7UCB Pharma, Brussels, Belgium, 8Geneva University Hospital, Geneva, Switzerland

    Background/Purpose: BMD is a strong predictor of fracture risk in untreated patients. Recent evidence suggests that BMD achieved during treatment also reflects fracture risk; thus,…
  • Abstract Number: 321 • 2016 ACR/ARHP Annual Meeting

    Results of a Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of Romosozumab in Men with Osteoporosis

    EM Lewiecki1, S Horlait2, T Blicharski3, S Goemaere4, K Lippuner5, P Meisner6, PD Miller7, A Miyauchi8, J Maddox9, NS Daizadeh9 and A Grauer9, 1New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, 2Amgen Ltd., Uxbridge, United Kingdom, 3Medical University of Lublin, Lublin, Poland, 4Ghent University Hospital, Gent, Belgium, 5Bern University Hospital, Bern, Switzerland, 6UCB Pharma, Brussels, Belgium, 7Colorado Center for Bone Research, Lakewood, CO, 8Miyauchi Medical Center, Osaka, Japan, 9Amgen Inc., Thousand Oaks, CA

    Background/Purpose: Treatment with romosozumab (Romo) has been shown to rapidly increase BMD in postmenopausal women with low BMD through a dual effect on bone, increasing…
  • Abstract Number: 323 • 2016 ACR/ARHP Annual Meeting

    Effect of 10 Years of Denosumab Treatment on Bone Histology and Histomorphometry in the Freedom Extension Study

    David W Dempster1,2, NS Daizadeh3, A Fahrleitner-Pammer4, Jens-Erik Beck Jensen5, DL Kendler6, Ivo Valter7, Rachel B Wagman3, Susan Yue3 and Jacques P Brown8, 1Columbia University, New York, NY, 2Helen Hayes Hospital, West Haverstraw, NY, 3Amgen Inc., Thousand Oaks, CA, 4Medical University, Graz, Austria, 5Hvidovre University Hospital, Hvidovre, Denmark, 6University of British Columbia, Vancouver, BC, Canada, 7Center for Clinical and Basic Research, Tallinn, Estonia, 8Centre Hospitalier de l'Université Laval (CHUL), Quebec City, QC, Canada

    Background/Purpose: Denosumab (DMAb) has been associated with low incidence of spine and non-spine, including hip, fractures through 10 years of treatment (Bone ASBMR 2015). Questions…
  • Abstract Number: 336 • 2016 ACR/ARHP Annual Meeting

    The Risk of Subsequent Osteoporotic Fractures Is Decreased in Patients Experiencing Fracture While on Denosumab

    DL Kendler1, A Chines2, ML Brandi3, S Papapoulos4, EM Lewiecki5, J-Y Reginster6, C Roux7, M Munoz Torres8, A Wang2 and HG Bone9, 1University of British Columbia, Vancouver, BC, Canada, 2Amgen Inc., Thousand Oaks, CA, 3University of Florence, Florence, Italy, 4Leiden University Medical Center, Leiden, Netherlands, 5New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, 6University of Liège, Liège, Belgium, 7Paris Descartes University, Paris, France, 8Hospital Universitario San Cecilio, Granada, Spain, 9Michigan Bone and Mineral Clinic, Detroit, MI

    Background/Purpose:  Osteoporosis is a common, progressive condition leading to increased bone fragility and susceptibility to fracture.  Although osteoporosis therapy decreases fracture risk, fractures while on…
  • Abstract Number: 337 • 2016 ACR/ARHP Annual Meeting

    Denosumab Treatment for 10 Years in Postmenopausal Women with Osteoporosis Was Associated with Substantially Lower Fracture Incidence Relative to Their Baseline FRAX-Predicted Probability

    E Siris1, N Pannacciulli2, PD Miller3, EM Lewiecki4, R Chapurlat5, E Jódar-Gimeno6, NS Daizadeh2, RB Wagman2 and JA Kanis7, 1Columbia University Medical Center, New York, NY, 2Amgen Inc., Thousand Oaks, CA, 3Colorado Center for Bone Research, Lakewood, CO, 4New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, 5Hôpital Edouard Herriot, Lyon, France, 6Hospital Universitario Quirónsalud Madrid, Madrid, Spain, 7University of Sheffield, Sheffield, United Kingdom

    Background/Purpose:  Denosumab is approved for treating postmenopausal women with osteoporosis at high risk for fracture.  The placebo-controlled FREEDOM trial and its active-treatment Extension investigated the…
  • Abstract Number: 1023 • 2016 ACR/ARHP Annual Meeting

    Fracture Risk Reduction with Romosozumab: Results of a Phase 3 Study in Postmenopausal Women with Osteoporosis

    F Cosman1, DB Crittenden2, JD Adachi3, N Binkley4, E Czerwinski5, S Ferrari6, LC Hofbauer7, E Lau8, EM Lewiecki9, A Miyauchi10, CAF Zerbini11, CE Milmont2, L Chen2, J Maddox2, PD Meisner12, C Libanati12 and A Grauer2, 1Helen Hayes Hospital, West Haverstraw, and Columbia University, New York, NY, 2Amgen Inc., Thousand Oaks, CA, 3McMaster University, Hamilton, ON, Canada, 4University of Wisconsin–Madison Osteoporosis Clinical Center and Research Program, Madison, WI, 5Krakow Medical Center, Krakow, Poland, 6Geneva University Hospital, Geneva, Switzerland, 7Division of Endocrinology, Diabetes, and Bone Diseases, TU Dresden Medical Center, Dresden, Germany, 8Center for Clinical and Basic Research, Hong Kong, China, 9New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, 10Miyauchi Medical Center, Osaka, Japan, 11Centro Paulista de Investigação Clinica, São Paulo, Brazil, 12UCB Pharma, Brussels, Belgium

    Background/Purpose:  Romosozumab (Romo) is an investigational bone-forming monoclonal antibody that binds sclerostin and has a dual effect, increasing bone formation and decreasing bone resorption. Here,…
  • Abstract Number: 1024 • 2016 ACR/ARHP Annual Meeting

    Superior Gains in Bone Mineral Density and Estimated Strength at the Hip for Romosozumab Compared with Teriparatide in Women with Postmenopausal Osteoporosis Transitioning from Bisphosphonate Therapy: Results of a Phase 3, Open-Label Clinical Trial

    B Langdahl1, C Libanati2, DB Crittenden3, MA Bolognese4, JP Brown5, NS Daizadeh3, K Engelke6, HK Genant7, S Goemaere8, Lars Hyldstrup9, E Jodar-Gimeno10, TM Keaveny11, D Kendler12, P Lakatos13, J Maddox3, J Malouf14, FE Massari15, JF Molina16, MR Ulla17 and A Grauer3, 1Aarhus University Hospital, Aarhus, Denmark, 2UCB Pharma, Brussels, Belgium, 3Amgen Inc., Thousand Oaks, CA, 4Bethesda Health Research Center, Bethesda, MD, 5Laval University and CHU de Québec (CHUL) Research Centre, Quebec City, QC, Canada, 6BioClinica Inc., Hamburg, Germany, 7Department of Radiology, University of California San Francisco, San Francisco, CA, 8Ghent University Hospital, Gent, Belgium, 9Hvidovre University Hospital, Hvidovre, Denmark, 10Servicio de Endocrinología, Hospital Universitario Quirón, Madrid, Spain, 11University of California at Berkeley, Berkeley, CA, 12University of British Columbia, Vancouver, BC, Canada, 13Department of Medicine, Semmelweis University, Budapest, Hungary, 14Universitat Autònoma de Barcelona, Barcelona, Spain, 15Instituto de Investigaciones Metabólicas, Buenos Aires, Argentina, 16Reumalab Centro Integral de Reumatologia, Medellin, Colombia, 17Instituto Latinoamericano de Investigaciones Médicas, Córdoba, Argentina

    Background/Purpose:  STRUCTURE was a phase 3, open-label study evaluating the effect of romosozumab or teriparatide for 12 months in women with postmenopausal osteoporosis transitioning from…
  • Abstract Number: 1028 • 2016 ACR/ARHP Annual Meeting

    Discontinuation of Denosumab and Associated Vertebral Fracture Incidence: Analysis from a Phase 3 Placebo-Controlled Study of Denosumab and Its Open-Label Extension

    Jacques P Brown1, S Ferrari2, N Gilchrist3, Jens-Erik Beck Jensen4, N Pannacciulli5, Chris Recknor6, Christian Roux7, Shawna Smith5, Ove Törring8, Ivo Valter9, Rachel B Wagman5, A Wang5 and SR Cummings10, 1Centre Hospitalier de l'Université Laval (CHUL), Quebec City, QC, Canada, 2Geneva University Hospital, Geneva, Switzerland, 3The Princess Margaret Hospital, Christchurch, New Zealand, 4Hvidovre University Hospital, Hvidovre, Denmark, 5Amgen Inc., Thousand Oaks, CA, 6United Osteoporosis Centers, Gainesville, GA, 7Paris Descartes University, Paris, France, 8Karolinska Institutet Sodersjukhuset, Stockholm, Sweden, 9Center for Clinical and Basic Research, Tallinn, Estonia, 10SFCC, CPMC Research Institute & UCSF, San Francisco, CA

    Background/Purpose: Denosumab (DMAb) treatment has been shown to decrease fracture (Fx) risk. Unlike bisphosphonates, DMAb is a monoclonal antibody against RANKL. Discontinuation is characterized by…
  • Abstract Number: 125 • 2015 ACR/ARHP Annual Meeting

    Implementation of a Bone Health Team Markedly Improves Osteoporosis Screening, Diagnosis and Treatment Initiation Rates Compared to Standard Primary Care Practice

    Karla L. Miller1,2, Marissa P. Grotzke1, Phillip Lawrence3, Yanina Rosenblum4, Richard Nelson5,6, Joanne Lafleur7,8 and Grant W. Cannon1, 1Internal Medicine, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, UT, 2Internal Medicine-Division of Rheumatology, University of Utah School of Medicine, SLC, UT, 3Pharmacology, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 4Veterans Affairs Salt Lake City Health Care System, Salt Lake City, UT, 5Epidemiology, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, UT, 6Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, UT, 7Pharmacology, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, UT, 8University of Utah College of Pharmacy, Salt Lake City, UT

    Background/Purpose:  Despite the availability of effective therapies for fracture prevention, osteoporosis screening and treatment rates in practice are low.   Fracture liaison services are effective at…
  • Abstract Number: 2255 • 2014 ACR/ARHP Annual Meeting

    Vertebral Cortical Bone Mass and Structure Significantly Improved with Romosozumab Compared with Teriparatide: HR-QCT Analyses of Postmenopausal Women with Low BMD from a Phase 2 Study

    T Damm1, C Libanati2, J Peña1, G Campbell1, R Barkmann1, DA Hanley3, S Goemaere4, MA Bolognese5, C Recknor6, C Mautalen7, YC Yang2 and CC Glüer1, 1Christian-Albrechts-Universität zu Kiel, Kiel, Germany, 2Amgen Inc., Thousand Oaks, CA, 3University of Calgary, Calgary, AB, Canada, 4Ghent University Hospital, Ghent, Belgium, 5Bethesda Health Research Center, Bethesda, MD, 6United Osteoporosis Centers, Gainesville, GA, 7Centro de Osteopatias Medicas, Buenos Aires, Argentina

    Background/Purpose : Understanding the effect of therapies in the vertebral compartments is relevant to bone biology and clinical practice. We developed an improved technique using…
  • Abstract Number: 234 • 2014 ACR/ARHP Annual Meeting

    The Decrease in Prescription of Anti-Osteoporotic Drugs Has No Impact on Hip Fracture Incidence

    Karine Briot1, Milka Maravic2 and Christian Roux3, 1Cochin Hospital, Paris Descartes University, Paris, France, 2Hopital Leopold Bellan, Paris, France, 3Paris Descartes University, Cochin Hospital, Paris, France

    Background/Purpose Controversies exist about the change in hip fracture incidence among countries. In France, we previously showed that the incidence of hip fractures decreased in…
  • Abstract Number: 49 • 2014 ACR/ARHP Annual Meeting

    Long-Term Oral Bisphosphonate Use for Osteoporosis Among Older Women – US and Canadian Perspective

    Nicole C. Wright1, Wilson Smith2, Amy H. Warriner3, Jeff Foster4, Ruth McConnell5, Huifeng Yun6, Mary H Melton7, Jeffrey R. Curtis4 and Kenneth G. Saag8, 1Epidemiology, The University of Alabama at Birmingham, Birmingham, AL, 2Clinical Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3Endocrinology, Diabetes, and Metabolism, The University of Alabama at Birmingham, Birmingham, AL, 4The University of Alabama at Birmingham, Birmingham, AL, 5University of Alabama at Birmingham, Birmingham, AL, 6Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, 7Medicine, The University of Alabama at Birmingham, Birmingham, AL, 8Immunology & Rheumatology, The University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Bisphosphonates (BPs) have been widely used for the treatment and prevention of osteoporosis for two decades. Although new parenteral preparations have been introduced, oral…
  • Abstract Number: 48 • 2014 ACR/ARHP Annual Meeting

    Osteoporotic Women at High Risk for Fractures Despite Two Years of Oral Bisphosphonate Therapy: Analysis Using the Canadian Multicentre Osteoporosis Study

    Jonathan D. Adachi1, David Goltzman2, Ankita Modi3, Jackson Tang4, Chun-Po S. Fan4 and Jessica Weaver3, 1Division of Rheumatology, McMaster University, Hamilton, ON, Canada, 2McGill University, Montreal, QC, Canada, 3Global Health Outcomes, Merck & Co., Inc., Whitehouse Station, NJ, 4Asclepius Analytics, New York, NY

    Background/Purpose Individuals with osteoporosis (OP) have an increased susceptibility to fractures. Prevention and treatment of postmenopausal OP is critical to decreasing the risk of non-traumatic…
  • Abstract Number: 1219 • 2013 ACR/ARHP Annual Meeting

    Phase 3 Fracture Trial Of Odanacatib For Osteoporosis – Baseline Characteristics and Study Design

    Socrates Papapoulos1, Henry G. Bone2, David W. Dempster3, John Eisman4, Susan Greenspan5, Michael McClung6, Toshitaka Nakamura7, Joseph Shih8, Albert Leung9, Arthur Santora10, N. Verbruggen11 and Antonio Lombardi12, 1Leiden University Medical Center, Leiden, Netherlands, 2Michigan Bone and Mineral Clinic, Detroit, MI, 3Regional Bone Center, Helen Hayes Hospital, West Haverstraw, NY, 4The Garvan Institute of Medical Research, Sydney, Australia, 5University of Pittsburgh, Pittsburgh, PA, 6Oregon Osteoporosis Center, Portland, OR, 7University of Occupational & Environmental Health, Fukuoaka, Japan, 8Robert Wood Johnson Medical School, Piscataway, NJ, 9Clinical Research, Merck Sharp and Dohme Corp., Rahway, NJ, 10Merck Sharp & Dohme Corp., Whitehouse Station, NJ, 11MSD Belgium, Brussels, Belgium, 12Merck Sharp and Dohme Corp., Rahway, NJ

    Background/Purpose: Odanacatib is a selective and reversible inhibitor of cathepsin K; a collagenase secreted by osteoclasts, and is currently being evaluated for the treatment of…
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