osteophytosis and synovitis Archives

Abstract Number: 771 • ACR/ARHP Annual Meeting 2013
The S100A9 Inhibitor Paquinimod (ABR-215757) Reduces Synovial Activation, Osteophyte Formation and Cartilage Damage In Experimental Osteoarthritis
Rik Schelbergen¹, Arjen B. Blom¹, Tomas Leanderson², Helena Eriksson³, Wim B. van den Berg⁴ and Peter L.E.M. van Lent¹, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Immunology Group, Lund University, Lund, Sweden, ³BioScience, Active Biotech AB, Lund, Sweden, ⁴Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Synovial activation is present in a large subset of osteoarthritis (OA) patients and it is thought to play an important role in the development…
Abstract Number: 46 • ACR/ARHP Annual Meeting 2013
Alarmins S100A8/A9 Regulate Osteophyte Formation In Experimental Osteoarthritis With High Synovial Activation
Rik Schelbergen¹, Arjen B. Blom¹, Wouter de Munter¹, Annet W. Sloetjes², Thomas Vogl³, Johannes Roth⁴, Wim B. van den Berg⁵ and Peter L.E.M. van Lent¹, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ³Institute of Immunology, University of Muenster, Muenster, Germany, ⁴Immunology, Institute of Immunology University of Muenster, Muenster, Germany, ⁵Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Osteophytes are cartilage capped, bony outgrowths that limit joint movement and originate from the periosteum or from ligaments during osteoarthritis (OA). There is increasing…

Abstracts tagged "osteophytosis and synovitis"

The S100A9 Inhibitor Paquinimod (ABR-215757) Reduces Synovial Activation, Osteophyte Formation and Cartilage Damage In Experimental Osteoarthritis

Alarmins S100A8/A9 Regulate Osteophyte Formation In Experimental Osteoarthritis With High Synovial Activation