Abstracts tagged "osteonecrosis and therapeutic targeting"

Abstract Number: 34 • 2014 ACR/ARHP Annual Meeting
Pro-Nerve Growth Factor (ProNGF) Stimulates Bone Growth By Stimulating Osteoblasts and Inhibiting Osteoclast Differentiation, an Explanation for Anti-NGF-Mediated Osteonecrosis; Prongf Is a Novel Therapeutic Target for Treatment of Osteonecrosis and Charcot’s Arthropathy
Aranzazu Mediero¹, Barbara Hempstead² and Bruce N. Cronstein³, ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, ³NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Neurotrophins (Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF)) are initially synthesized as pro-neurotrophins (proNGF and proBDNF), which are hydrolyzed to produce the…

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Abstracts tagged "osteonecrosis and therapeutic targeting"

Pro-Nerve Growth Factor (ProNGF) Stimulates Bone Growth By Stimulating Osteoblasts and Inhibiting Osteoclast Differentiation, an Explanation for Anti-NGF-Mediated Osteonecrosis; Prongf Is a Novel Therapeutic Target for Treatment of Osteonecrosis and Charcot’s Arthropathy