ACR Meeting Abstracts

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Abstracts tagged "osteoclasts"

  • Abstract Number: 1915 • 2014 ACR/ARHP Annual Meeting

    IL-17 Gene Transfer induces Myeloid Precursor Cells That Initiate Epidermal Hyperplasia Independently of IL-23R+/CD4+ and γδ T Cells

    Erika Suzuki1, Ritu Sarin2, Emanual Maverakis1 and Iannis E. Adamopoulos2, 1University of California at Davis, Sacramento, CA, 2Internal Medicine, University of California at Davis, Sacramento, CA

    Background/Purpose: IL-17 is elevated in both the lesional skin and arthritic joints of psoriatic arthritis (PsA) patients. Although the IL-23/IL-17 axis has been linked with…
  • Abstract Number: 1890 • 2014 ACR/ARHP Annual Meeting

    Consistent Inhibition of Bone Destruction By Denosumab in Important Subgroups of Japanese Patients with Rheumatoid Arthritis

    Naoki Ishiguro1, Yoshiya Tanaka2, Hisashi Yamanaka3, Toshiyuki Yoneda4, Takeshi Ohira5, Naoki Okubo6, Harry K. Genant7, Desiree van der Heijde8 and Tsutomu Takeuchi9, 1Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 3Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan, 4Indiana University School of Medicine, Indianapolis, IN, 5Daiich Sankyo Co. Ltd, Tokyo, Japan, 61-2-58, Hiromachi, Daiichi Sankyo Co. Ltd, Tokyo, Japan, 7University of California, San Francisco, CCBR-Synarc, Newark, Tiburon, CA, 8Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 9Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose Denosumab is a fully human monoclonal antibody (IgG2 subclass) that binds specifically to RANKL, inhibits osteoclast-induced bone resorption by preventing the binding of RANKL…
  • Abstract Number: 38 • 2014 ACR/ARHP Annual Meeting

    Angiopoietin-like 4 Is over-Expressed in Rheumatoid Arthritis: A Potential Role in Pathological Bone Resorption

    Catherine Swales1, Nick Athanasou2 and Helen Knowles3, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Botnar Research Centre, Oxford, United Kingdom, 2Nuffield Orthopaedic Centre, Department of Pathology, Oxford, United Kingdom, 3Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Oxford, United Kingdom

    Background/Purpose In contrast to normal synovial tissue, rheumatoid synovium is hypoxic, and expresses the hypoxia-inducible transcription factors HIF-1α and HIF-2α which allow the transcription of…
  • Abstract Number: 2730 • 2013 ACR/ARHP Annual Meeting

    Netrin1 Is a Critical Autocrine Factor For Osteoclast Differentiation

    Aranzazu Mediero1, Bhama Ramkhelawon2, Kathryn Moore2, P. Edward Purdue3, Steven R. Goldring4 and Bruce N. Cronstein5, 1Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, 2Leon H. Charney Division of Cardiology, Department of Medicine,, NYU School of Medicine, New York, NY, 3Research, Hospital for Special Surgery, New York, NY, 4Hospital for Special Surgery, New York, NY, 5Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: Netrins have been extensively studied for their role in axonal guidance during neural development. In addition, netrins are chemopulsants for a variety of non-neuronal…
  • Abstract Number: 2236 • 2013 ACR/ARHP Annual Meeting

    Articular Inflammation Is Protected By Fat-1 During The Acute Phase Of Arthritis In Mice

    Sang-Il Lee1, Yun-Hong Cheon2, Ji-Min Kim3 and Won Seok Lee2, 1Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, 2Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea

    Background/Purpose: Omega-3 polyunsaturated fatty acids (n-3 PUFA) are well known to exert anti-inflammatory effects. The Fat-1 transgenic (Fat-1 TG) mice are capable of producing n-3…
  • Abstract Number: 1833 • 2013 ACR/ARHP Annual Meeting

    Combination Of TNF and IL-6 Induces Osteoclast-Like Cells With Bone-Resorption Activity Both In Vitro and In Vivo

    Kazuhiro Yokota, Kojiro Sato and Toshihide Mimura, Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose: Although TNF inhibitors suppress bone destruction in patients with rheumatoid arthritis (RA), TNFα stimulation alone does not directly induce osteoclasts, bone-resorbing cells. With the…
  • Abstract Number: 955 • 2013 ACR/ARHP Annual Meeting

    Myeloid Deletion Of SIRT1 Aggravates Serum Transfer Arthritis But Ameliorate Collagen-Induced Arthritis

    Sang-Il Lee1, Yun-Hong Cheon2, Won Seok Lee2 and Ji-Min Kim3, 1Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, 2Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea

    Background/Purpose: SIRT1 plays a pivotal role in regulating the inflammatory response. Thus, we assessed the role of SIRT1 in K/BxN serum transfer arthritis as a…
  • Abstract Number: 307 • 2013 ACR/ARHP Annual Meeting

    Abnormal Imaging and Increased Osteoclast Precursors In a Psoriasis Cohort Are Associated with New Onset of Psoriatic Arthritis

    Ralf G. Thiele1, Yahui Grace Chiu1, Francisco A. Tausk2, Bethany A. Marston1, Gregory Dieudonne3, Vaseem Chengazi3, Michelle Smith1, Sharon Moorehead1, Rick Barrett1 and Christopher T. Ritchlin1, 1Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 2Dermatology, University of Rochester, Rochester, NY, 3Radiology, University of Rochester, Rochester, NY

    Background/Purpose: Psoriasis (Ps) precedes joint inflammation by about 10 years in patients who develop psoriatic arthritis (PsA). Several studies have documented abnormal musculoskeletal imaging findings…
  • Abstract Number: 2616 • 2012 ACR/ARHP Annual Meeting

    The Transition From Psoriasis (Ps) to Psoriatic Arthritis (PsA) Is Associated with Elevated Circulating Osteoclast Precursors (OCP) and Increased Expression of DC-STAMP

    Ya-Hui Chiu1, Edward M. Schwarz2, Dafna D. Gladman3, Sharon Moorehead4, Michelle Smith4, Rick Barrett4 and Christopher T. Ritchlin4, 1Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, 2Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 3Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, 4Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY

    Background/Purpose: Approximately 20% of psoriasis (Ps) patients (pts) develop psoriatic arthritis (PsA). Early diagnosis and therapy of PsA can limit bone and joint damage; however,…
  • Abstract Number: 1207 • 2012 ACR/ARHP Annual Meeting

    Impact of Anti Tumor Necrosis Factor-Alpha Therapy in Rheumatoid Arthritis On Osteoclast Activation and B Cells

    Ezinma Ezealah1, Jennifer Hossler1, Jamie Biear1, Christopher A. Cistrone1, Teresa Owen1, Nida Meednu1, Kelly Callahan1, Arumugam Palanichamy1, Ignacio Sanz2, Allen P. Anandarajah1, Ralf G. Thiele1, Darren Tabechian3, R. John Looney1 and Jennifer H. Anolik1, 1Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 2Rheumatology, Emory University, Atlanta, GA, 3Allergy/Immun/Rheumatology, Univ of Rochester Schl of Med, Rochester, NY

    Background/Purpose:  Serum receptor activator of NFkB ligand (RANKL) and its natural decoy receptor, osteoprotegerin (OPG), play key roles in osteoclast activation. In a group of…
  • Abstract Number: 21 • 2012 ACR/ARHP Annual Meeting

    IL-32 and IL-17 Interact and Aggravate Osteoclastogenesis in Rheumatoid Arthritis

    Bo Young Yoon1, Young-Mee Moon2, Yang-Mi Her2, Hye Jwa Oh2, Jae-Seon Lee2, Kyoung-Woon Kim3, Seon-Yeong Lee2, Yun-Ju Woo2, Kyung-Su Park2, Sung-Hwan Park4, Ho-Youn Kim2 and Mi-La Cho2, 1Inje University Ilsan Paik Hospital, Goyang, South Korea, 2Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, 3Conversant Research Consortium in Immunologic disease, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, 4Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea

    Background/Purpose: Interleukin (IL)-32 and IL-17 play critical roles in pro-inflammatory responses and are highly expressed in the synovium of patients with rheumatoid arthritis (RA). We…
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