Abstracts tagged "osteoclasts and tumor necrosis factor (TNF)"

Abstract Number: 1986 • 2018 ACR/ARHP Annual Meeting
Adalimumab:TNF Complexes Are Cleared More Efficiently By Human Osteoclasts Than Those with Etanercept through Fcg-Receptor Binding and Internalization
Bohdan P. Harvey, Joel Cohen-Solal and Zehra Kaymakcalan, Biologics, AbbVie Bioresearch Center, Worcester, MA
Background/Purpose: TNF-alpha (TNFa) has been shown to contribute to osteoclastogenesis (OCgenesis) independently and in conjunction with M-CSF or RANKL, two key cytokines involved in osteoclast…
Abstract Number: 2232 • 2013 ACR/ARHP Annual Meeting
Neutralization of Angiopoietin-2 Enhances the Efficacy of Anti-Tumor Necrosis Factor-Alpha Treatment in a Mouse Model of Rheumatoid Arthritis by Decreasing Cellular Infiltration into the Joint and Protecting Bone
Brian Naiman, Sean Turman, William Iverson, Ronald Herbst, Tomas Mustelin and Jane Connor, Respiration, Inflammation and Autoimmunity, MedImmune, LLC, Gaithersburg, MD
Background/Purpose: It has recently been established that >75% of patients on methotrexate and a biologic do not achieve complete remission based on the new definition…

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