osteoclasts and rheumatoid arthritis Archives

Abstract Number: 1074 • ACR/ARHP Annual Meeting 2017
High Cholesterol Levels By ApoE Defenciency Reduce Bone Destruction in Murine Antigen-Induced Arthritis Via Inhibition of Osteoclastogenesis
Giuliana Ascone¹, Irene Di Ceglie¹, Arjen B. Blom¹, Birgitte Walgreen², Annet W. Sloetjes¹, Peter M. van der Kraan¹, Ernst Lindhout³, Mike Martens³ and Peter L. van Lent⁴, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental, Radboud university medical center, Nijmegen, Netherlands, ³Future Diagnostics Solutions (FDs), Wijchen, Netherlands, ⁴Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by immune complex- deposition in the synovium, leading to increased bone destruction. In RA, joint…
Abstract Number: 1335 • ACR/ARHP Annual Meeting 2017
p62/SQSTM1 Modulates Bone Erosions in a Murine Model of Rheumatoid Arthritis
Adelheid Korb-Pap¹, Anja Römer-Hillmann¹, Marianne Heitzmann¹, Masaru Kato², Kerstin Klein², Caroline Ospelt², Steffen Gay³, Susanne Buergis⁴, Thomas Pap¹, Thomas Weide⁵, André Gessner⁴ and Hermann Pavenstädt⁵, ¹Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ²Center of Experimental Rheumatology, University Hospital Zürich, Zurich, Switzerland, ³Center of Experimental Rheumatology, University Hospital Zürich, Zürich, Switzerland, ⁴Department of Immunology, University Erlangen, Erlangen, Germany, ⁵Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany
Background/Purpose: Rheumatoid arthritis (RA) is characterised by massive bone erosions leading to irreversible joint destructions. In this context, the multi-adapter protein p62/SQSTM1 is of interest…
Abstract Number: 1128 • ACR/ARHP Annual Meeting 2016
Anti-Fractalkine Monoclonal Antibody Inhibits Cartilage Destruction and Bone Erosion in Collagen-Induced Arthritis Model
Kana Hoshino¹, Masayoshi Ohkuro², Wataru Ikeda¹, Tomoya Nakatani¹, Yoshikazu Kuboi³, Naoto Ishii¹, Toshihiko Yamauchi¹, Nobuyuki Yasuda¹ and Toshio Imai¹, ¹KAN Research Institute Inc., Chuo-ku, Kobe-shi, Japan, ²Research Project Promotion Group, EA Pharma Co., Ltd., Kawasaki-ku, Kawasaki-shi, Japan, ³Medicine Creation. Neuro Business Group, Eisai Co., Ltd., Tsukuba-shi, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction. In the previous Phase 1/2 clinical study, E6011, a novel humanized anti-fractalkine (FKN)…
Abstract Number: 1493 • ACR/ARHP Annual Meeting 2014
A Phase 1 Study of FPA008, an Anti-Colony Stimulating Factor 1 Receptor (anti-CSF1R) Antibody in Healthy Volunteers and Subjects with Rheumatoid Arthritis (RA): Preliminary Results
Julie Hambleton¹, Lei Zhou¹, Seema Rogers¹, Sjoerd van Marle², Thijs van Iersel², James Zanghi¹, Emma Masteller¹, Kevin Baker¹ and Brian Wong¹, ¹Five Prime Therapeutics, South San Francisco, CA, ²PRA Health Sciences, Groningen, Netherlands
Background/Purpose Activation of CSF1R via IL34 or CSF1 results in activation, differentiation, and survival of monocytes, macrophages and osteoclasts. CSF1R activation produces inflammatory cytokines responsible…
Abstract Number: 26 • ACR/ARHP Annual Meeting 2014
Functional Osteoclasts Differentiate Spontaneously from the Rheumatoid Joint
Stinne Greisen¹, Halldór Bjarki Einarsson², Malene Hvid³, Ellen Margrethe Hauge^4,5, Bent Deleuran^3,6 and Tue Kragstrup⁷, ¹Dept of Biomedicine, Aarhus University, Aarhus, Denmark, ²Dept. of Biomedicine, Aarhus University, Aarhus, Denmark, ³Department of Biomedicine, Aarhus University, Aarhus, Denmark, ⁴Dept. of Anatomi, Aarhus University, Aarhus, Denmark, ⁵Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁶Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁷Aarhus University, Aarhus, Denmark
Functional osteoclasts differentiate spontaneously from the rheumatoid joint Background/Purpose Osteoimmunology is a field of emerging interest in which bone formation and resorption are understood in…
Abstract Number: 1152 • ACR/ARHP Annual Meeting 2013
Ligation Of TLR5 Promotes Myeloid Cell Infiltration and Differentiation Into Mature Osteoclasts In RA Patients and Experimental Arthritis
Seung-jae Kim¹, Zhenlong Chen¹, Nathan D. Chamberlain¹, Michael V. Volin², Suncica Volkov¹, William Swedler³, Shiva Arami⁴, Anjali Mehta⁵, Nadera J. Sweiss⁶ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ³Section of Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁴Medicine - Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁵University of Illinois at Chicago, Chicago, IL, ⁶internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of this study was to examine the importance of TLR5 ligation in the pathogenesis of rheumatoid arthritis (RA) and experimental arthritis. Methods:…
Abstract Number: 2072 • ACR/ARHP Annual Meeting 2012
Bone Formation and Resorption Are Both Increased in Autoimmune Arthritis
Kresten K. Keller¹, Jesper Skovhus Thomsen², Kristian Stengaard-Pedersen¹, Frederik Dagnæs-Hansen³, Jens R. Nyengaard⁴ and Ellen-Margrethe Hauge¹, ¹Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ²Institute of Anatomy, Aarhus University, ³Institute of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark, ⁴Stereology and Electron Microscopy Laboratory, Centre for Stochastic Geometry and Advanced Bioimaging. Aarhus University hospital, Aarhus, Denmark
Background/Purpose: Bone destruction in the joints of patients with rheumatoid arthritis (RA) is the result of a combination of osteoclastic bone resorption and osteoblastic bone…

Abstracts tagged "osteoclasts and rheumatoid arthritis"

High Cholesterol Levels By ApoE Defenciency Reduce Bone Destruction in Murine Antigen-Induced Arthritis Via Inhibition of Osteoclastogenesis

p62/SQSTM1 Modulates Bone Erosions in a Murine Model of Rheumatoid Arthritis

Anti-Fractalkine Monoclonal Antibody Inhibits Cartilage Destruction and Bone Erosion in Collagen-Induced Arthritis Model

A Phase 1 Study of FPA008, an Anti-Colony Stimulating Factor 1 Receptor (anti-CSF1R) Antibody in Healthy Volunteers and Subjects with Rheumatoid Arthritis (RA): Preliminary Results

Functional Osteoclasts Differentiate Spontaneously from the Rheumatoid Joint

Ligation Of TLR5 Promotes Myeloid Cell Infiltration and Differentiation Into Mature Osteoclasts In RA Patients and Experimental Arthritis

Bone Formation and Resorption Are Both Increased in Autoimmune Arthritis