Abstracts tagged "osteoclasts and rheumatoid arthritis (RA)"

Abstract Number: 39 • 2012 ACR/ARHP Annual Meeting
SDF-1 Induces Osteoclastogenesis in Rheumatoid Arthritis by Upregulating of RANKL Expression in Synovial Fibroblasts and CD4+ T Cells
Hae-Rim Kim¹, Kyoung-Woon Kim², Bo-Mi Kim¹, Mi La Cho³ and Sang-Heon Lee⁴, ¹Division of Rheumatology, Konkuk University School of Medicine, Seoul, South Korea, ²Conversant Research Consortium in Immunologic disease, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ³Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ⁴Dept of Internal Medicine, Konkuk University Hospital, Seoul, South Korea
Background/Purpose: Stromal cell-derived factor (SDF)-1 is involved in bone destructive process in rheumatoid arthritis (RA) and bony metastasis in malignancy, through inducing angiogenesis, producing matrix-degrading…
Abstract Number: 2666 • 2012 ACR/ARHP Annual Meeting
A Link Between B Cells and Bone Erosion in RA: RANKL Production by Memory B Cells
Nida Meednu¹, Teresa Owen², Hengwei Zhang³, Christopher A. Cistrone¹, Lianping Xing⁴ and Jennifer H. Anolik⁵, ¹Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ²Allergy, Immununolgy and Rheumatology,, University of Rochester, Rochester, NY, ³Pathology and Laboratory Medicine, University of Rochester, Rochester, NY, ⁴Pathology & Lab Medicine, University of Rochester, Rochester, NY, ⁵Medicine- Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disorder that often leads to joint damage. Several lines of evidence suggests the role of B cells…

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