Abstracts tagged "osteoclastogenesis and signal transduction"

Abstract Number: 215 • ACR/ARHP Annual Meeting 2015
Calcium Hydroxyapatite Crystals Inhibit Interleukin-6- and Interferon-γ –Induced Anti-Osteoclastogenic Signaling in Human Osteoclast Precursors
Geraldine M. McCarthy¹, Clare C. Cunningham², Emma M. Corr³ and Aisling Dunne³, ¹University College Dublin, Dublin, Ireland, ²School of Biochemistry and Immunology, Trinity College Dublin, Dubln, Ireland, ³School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Background/Purpose: Intra-articular calcium hydroxyapatite (HA) crystals are present in the majority of osteoarthritic (OA) joints. They activate macrophages, synovial fibroblasts and articular chondrocytes, resulting in…
Abstract Number: 2204 • ACR/ARHP Annual Meeting 2015
Tankyrase Regulates Osteoclastogenesis Via SH3BP2 Expression
Tomoyuki Mukai, Shunichi Fujita, Takafumi Mito, Akiko Nagasu, Yumi Sasae, Hiroyasu Hirano and Yoshitaka Morita, Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan
Background/Purpose: SH3BP2, an adaptor protein, is dominantly expressed in immune cells including macrophages and regulates intracellular signaling pathways. Gain-of-function mutations in SH3BP2 cause human genetic…