ACR Meeting Abstracts

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Abstracts tagged "osteoclastogenesis and rheumatoid arthritis"

  • Abstract Number: 961 • 2017 ACR/ARHP Annual Meeting

    Adalimumab Reduces CXCR4 Expression during Inflammatory Arthritis and in Fibroblast-like Synoviocytes and Osteoclasts Under Chronic TNF Exposure

    Bohdan P. Harvey1, Li Li1, Mark Konrad1, Heather Knight1, Susan Westmoreland2, Melanie Ruzek1 and Zehra Kaymakcalan1, 1AbbVie Bioresearch Center, Worcester, MA, 2AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA

    Background/Purpose: The CXCL12/CXCR4 chemokine axis has been implicated in the pathogenesis of RA. The expression of this chemokine and receptor has been shown to be…
  • Abstract Number: 1320 • 2017 ACR/ARHP Annual Meeting

    TAS5315, a Novel Bruton’s Tyrosine Kinase Inhibitor, Ameliorates Inflammation and Bone Erosion in Murine Model for Rheumatoid Arthritis

    Yohei Yoshiga1, Fumihito Hosoi1, Satoru Iguchi1, Ryuusuke Kaneko2, Yoshinori Nakachi1, Daichi Akasaka2, Kenji Tanaka2, Kazuhiko Yonekura2, Teruhiro Utsugi2, Eiji Sasaki2 and Yoshikazu Iwasawa2, 1TAIHO PHARMACEUTICAL CO., LTD., TSUKUBA, Japan, 2TAIHO PHARMACEUTICAL CO., LTD., Tsukuba, Japan

    Background/Purpose: The erosions of bone and cartilage are a cardinal feature of rheumatoid arthritis (RA) and associated with disease severity and poor functional outcome. Although…
  • Abstract Number: 1510 • 2014 ACR/ARHP Annual Meeting

    Blockade of TLR5 Ligation Is a Novel Strategy for RA Therapy  

    Seung-jae Kim1, Zhenlong Chen1, Abdul Essani2, Michael Volin3, Suncica Volkov1, William Swedler4, Shiva Arami2, Nadera J. Sweiss5 and Shiva Shahrara1, 1Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, 2University of Illinois at Chicago, Chicago, IL, 3Microbiology & Immunology, Midwestern University, Downers Grove, IL, 4Section of Rheumatology, University of Illinois at Chicago, Chicago, IL, 5internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL

    Background/Purpose: TLR5 expression is highly elevated in RA and CIA lining and sublining macrophages and endothelial cells compared to non-arthritic controls. Additionally, expression of TLR5…
  • Abstract Number: 39 • 2014 ACR/ARHP Annual Meeting

    Human CD14+ Monocytes Stimulated with a Combination of TNFα and IL-6 Differentiate into Osteoclast-like Cells with Bone-Resorption Activity

    Kazuhiro Yokota1, Kojiro Sato2, Yoshimi Aizaki2, Yuji Akiyama2 and Toshihide Mimura2, 1Department of Rheumatology & Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 2Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose Proinflammatory cytokines play an important role in bone destruction in rheumatoid arthritis (RA), as inferred by the efficacy of biologics. Previously, we reported that…
  • Abstract Number: 332 • 2012 ACR/ARHP Annual Meeting

    Blockade of CTGF Restores Aberrant Ostoclastgenesis in Collagen Induced Arthritis (CIA) Mice Through Inhibition of Th-17 Differentiation

    Kazuhisa Nozawa1, Maki Fujishiro2, Ayako Yamaguchi1, Mikiko Kawasaki2, Shouzou Ichinose2, Mitsuaki Yanagida2, Kazuhisa Iwabuchi2, Keigo Ikeda3, Shinji Morimoto4, Megumi Morioka5, Yoshinari Takasaki6 and Iwao Sekigawa3, 1Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 2Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan, 3Internal Medicine 2, Juntendo University Urayasu Hospital, Tomioka, Urayasu, Chiba, Japan, 4Juntendo University Urayasu Hospital, Tokyo, Japan, 5Nihon Nosan Corporation, Nihon Nosan Corporation, Kanagawa, Japan, 6Internal Medicine and Rheumatology,, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Our previous study demonstrated changes in the profiles of serum protein biomarkers in infliximab-treated rheumatoid arthritis (RA) patients using a novel approach to proteomic…
  • Abstract Number: 32 • 2012 ACR/ARHP Annual Meeting

    Development of a Quantitative Model of Endotoxin-Induced Calvarial Bone Erosion Utilizing Micro-Computed Tomography and Pax-It Imaging Analysis Software

    Diane Thome, Donald Souza, Aruna Behera, Jie Zheng, Jennifer Swantek and Gerald H. Nabozny, Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT

    Background/Purpose: To facilitate an understanding of the biological factors involved in inflammation- mediated bone loss, in vitro systems and murine models of bone loss, such…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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