Abstracts tagged "osteoclastogenesis and phospholipase"

Abstract Number: 1822 • ACR/ARHP Annual Meeting 2013
Oleanolic Acid Acetate Inhibits Osteoclast Differentiation By Downregulating Phospholipase Cγ² –calcium ion oscillation-Nuclear Factor Of Activated T Cell c1 Signaling, and Suppresses Bone Loss In Mice
Chang-Hoon Lee¹, Myeung Su Lee¹, Won Seok Lee², Wan-Hee Yoo³, Ju-Young Kim⁴, Jae-Min Oh⁴ and Yong-Geun Jeong⁵, ¹Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, ²Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ³Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ⁴Department of Anatomy, School of Medicine, Wonkwang University, Iksan, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Changwon Fatima Hospital, Changwon, South Korea
Background/Purpose: we first isolated oleanolic acid acetate (OAA), a triterpenoid compound, from Vigna angularis(azuki bean) to discover anti-bone resorptive agents. Many studies have identified and…