ACR Meeting Abstracts
Abstract Number: 68 • ACR/ARHP Annual Meeting 2017
Shunichi Fujita1, Tomoyuki Mukai1, Takafumi Mito1, Shoko Kodama1, Akiko Nagasu1, Mizuho Kittaka2, Yasuyoshi Ueki3 and Yoshitaka Morita1, 1Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, 2Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Missouri-Kansas City, MO, MO, 3Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Missouri-Kansas City, MO
Background/Purpose: Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Since tankyrase inhibitors increase Axin protein, a negative regulator…