ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "osteoclastogenesis and osteoclasts"

  • Abstract Number: 846 • 2018 ACR/ARHP Annual Meeting

    CD14 Deficiency Dampens Osteoclastogenesis and Alters Bone Remodeling in a Murine Model of Osteoarthritis

    Cheng Zhou1,2, Vu Nguyen2,3, Ryan Smalley2, Nisha Sambamurthy1,2, George R. Dodge2,4 and Carla Scanzello1,2, 1Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 2Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, 3University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 4Department of Orthopaedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

    Background/Purpose: Pathogenesis of osteoarthritis (OA) is accompanied by chronic inflammation evidenced by macrophage infiltration into the joint. CD14, is expressed by monocyte/macrophage lineage cells, and…
  • Abstract Number: 1570 • 2017 ACR/ARHP Annual Meeting

    Monocytes from Male Patients with Ankylosing Spondylitis Display Decreased Osteoclastogenesis and Decreased RANKL/OPG Ratio

    Valéria F. Caparbo1, Carla G.S. Saad1, Julio C. B. Moraes2, Artur J de Brum-Fernandes3 and Rosa M R Pereira4, 1Rheumatology Division, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil, 2Rheumatology Division, Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Brazil, 3Rheumatology Division, Université de Sherbrooke, Rheumatology Division, Canada, Sherbrooke, QC, Canada, 4Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

    Background/Purpose: Ankylosing Spondylitis (AS) is a chronic inflammatory disease characterized by new bone growth that leads to syndesmophyte formation and subsequent vertebral ankyloses, although AS…
  • Abstract Number: 1097 • 2016 ACR/ARHP Annual Meeting

    Tankyrase Regulates Osteoclastogenesis Via SH3BP2

    Shunichi Fujita, Tomoyuki Mukai, Takafumi Mito, Shoko Kodama, Akiko Nagasu, Hiroyasu Hirano and Yoshitaka Morita, Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan

    Background/Purpose: Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Axin, a regulatory protein of Wnt/β-catenin signaling, is one…
  • Abstract Number: 1442 • 2016 ACR/ARHP Annual Meeting

    Suppression of Acute Arthritis By N-Methyl-3,4-Dichloropropionaniline (N-MeDCPA), a Reversible Orai Calcium Channel Inhibitor

    John Barnett1, Lisa Robinson2, Jonathan Soboloff3, Rosana Schafer4, Ida Holaskova5, Meenal Elliott1, Michelle Witt2, Raphael Hirsch6 and Harry Blair7, 1Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, 2Pathology, West Virginia University, Morgantown, WV, 3Dept of Medical Genetics and Molecular Biochemistry, Temple University, Philadelphia, PA, 4Dept Micro, Immun & Cell Biol, West Virginia University, Morgantown, WV, 5West Virginia University, Morgantown, WV, 6Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, 7pathology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose:  Bone maintenance is a balance between the removal of old bone by osteoclasts (OCL) and the production of new bone by osteoblasts. In the…
  • Abstract Number: 2203 • 2015 ACR/ARHP Annual Meeting

    Loss of Wdfy3 Leads to Enhanced Osteoclastogenesis Via NF-κB Activation

    Dennis J. Wu1,2, Ran Gu2, Ritu Sarin2, Regina Zavodovskaya3, Chia-Pei Chen4, Konstantinos Zarbalis5,6 and Iannis E. Adamopoulos1,2,6, 1Graduate Group in Immunology, University of California, Davis, Davis, CA, 2Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, Davis, CA, 3Department of Anatomy, Physiology and Cell Biology, University of California, Davis, Davis, CA, 4Department of Statistics, University of California, Davis, Davis, CA, 5Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, 6Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children, Northern California, Sacramento, CA

    Background/Purpose: Autophagy and phagocytosis are conserved cellular functions involved in the protein degradation process in immunity. Recently, autophagy-related proteins were shown to regulate osteoclast mediated…
  • Abstract Number: 33 • 2014 ACR/ARHP Annual Meeting

    Stimulation of the Adenosine a2A receptor (A2AR) Regulates the Expression of Netrin1 and Their Receptors (Unc5b, DCC) and Inhibits Osteoclast Differentiation and Inflammatory Bone Destruction

    Aranzazu Mediero1, Bhama Ramkhelawon2, Miguel Perez-Aso3, Kathryn Moore2 and Bruce N. Cronstein4, 1Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, 2Leon H. Charney Division of Cardiology, Department of Medicine,, NYU School of Medicine, New York, NY, 3545 1st Ave., New York University, New York City, NY, 4NYU School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose A variety of molecules mediate communication between osteoclasts and osteoblasts during bone remodeling. Netrin1 is a member of the family of axonal guidance proteins,…
  • Abstract Number: 25 • 2014 ACR/ARHP Annual Meeting

    DC-STAMP Modulates Osteoblast Differentiation and Regulates Bone Repair

    Yahui Grace Chiu1, Tzong-Ren Sheu2, Jinbo Li3, Dongge Li1, Michael Thullen2, Brendan Boyce4, Edward Puzas2 and Christopher T. Ritchlin5, 1Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 2Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 3Pathology, University of Rochester, Rochester, NY, 4Pathology, University of Rochester, Rocehster, NY, 5Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY

    Background/Purpose Patients with osteoporosis and the elderly have an increased risk of bone fracture. Currently, no biomarker is available to assess bone healing status in…
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