Abstracts tagged "osteoblasts and rheumatoid arthritis (RA)"

Abstract Number: 917 • ACR/ARHP Annual Meeting 2016
B Cells Inhibit Osteoblast Differentiation in Inflammatory Arthritis
Wen Sun^1,2, Nida Meednu³, Alex Rosenberg¹, Javier Rangel-Moreno⁴, Victor Wang³, Teresa Owen¹, Hengwei Zhang⁵, Brendan Boyce¹, Jennifer H. Anolik¹ and Lianping Xing¹, ¹University of Rochester Medical Center, Rochester, NY, ²Nanjing Medical University, Nanjing, China, ³Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁴Allergy, Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁵Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is frequently associated with bone loss due to imbalanced bone resorption and formation. B cell depletion therapy (BCDT) attenuates bone erosion…
Abstract Number: 2085 • ACR/ARHP Annual Meeting 2012
T Cell-Mediated Murine Antigen-Induced Arthritis Is Resistant to Transgenic Disruption of Glucocorticoid Signaling in Osteoblasts and Osteocytes in Vivo
Cornelia M. Spies¹, Edgar Wiebe¹, Jinwen W. Tu², Aiqing Li², Timo Gaber¹, Dörte Huscher¹, Markus J. Seibel², Hong Zhou² and Frank Buttgereit³, ¹Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ²Bone Research Program, ANZAC Research Institute, The University of Sydney, Concord, Australia, ³Charité - Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: The role of endogenous glucocorticoids (GC) in, and their contribution to the susceptibility and severity of rheumatoid arthritis remains inconclusive. We previously demonstrated that…