Abstracts tagged "osteoblasts and rheumatic disease"

Abstract Number: 49 • 2017 ACR/ARHP Annual Meeting
G Protein-Coupled Receptor Kinase 3 Modulates Mesenchymal Stem Cell Proliferation and Differentiation through Sphingosine-1-Phosphate Receptor Regulation
Jaime M. Brozowski¹, Roman G. Timoshchenko², D. Stephen Serafin², Jessica Koontz², Brittney Allyn², Amanda M. Eudy³, Taylor Harris⁴, David Abraham⁴, Clinton T. Rubin⁵, Janet Rubin⁶, Nancy Allbritton⁴, Matthew J. Billard² and Teresa K. Tarrant⁷, ¹Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC, ⁴Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Biomedical Engineering, Stony Brook University, Stony Brook, NY, ⁶General endocrinology, metabolic bone diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁷Rheumatology and Immunology, Duke University, Durham, NC
Background/Purpose: Mesenchymal stem cells are multipotent stromal cells that can differentiate into tissue-specific lineages, such as osteocytes and chondrocytes. Their multipotency has made them an…

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