Abstracts tagged "osteoblasts and osteoclasts"

Abstract Number: 47 • 2017 ACR/ARHP Annual Meeting
Claudin-11 Regulates Bone Homeostasis Via Bidirectional EphB4-EphrinB2 Signaling
Jong Min Baek¹, Chong Hyuk Chung², Ju-Young Kim³, Wan-Hee Yoo⁴, Yunjung Choi⁵, Changhoon Lee⁶ and Myeung Su Lee⁷, ¹Department of Anatomy, School of Medicine, Wonkwang University, Iksan, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Wonkwnag University Hospital, Wonkwang University Hospital, IKSAN, Korea, Republic of (South), ³Imaging Science-based Lung and Bone Diseases Research Center, Wonkwang University, IKSAN, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, Korea, Republic of (South), ⁵Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Hospital, jeonju, Korea, Republic of (South), ⁶Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), ⁷Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Chonbuk, Korea, Republic of (South)
Background/Purpose: Claudins (Cldns) are well-established components of tight junctions (TJs) that play a pivotal role in the modulation of paracellular permeability. Several studies have explored…
Abstract Number: 1105 • 2016 ACR/ARHP Annual Meeting
Bone Metabolism in Rheumatic Diseases May be Affected By Free Fatty Acids
Klaus W. Frommer¹, Andreas Schäffler², Uwe Lange³, Stefan Rehart⁴, Jürgen Steinmeyer⁵, Markus Rickert⁶, Ulf Müller-Ladner⁷ and Elena Neumann¹, ¹Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ²Department of Internal Medicine III, Endocrinology, Diabetes, Metabolism, Justus-Liebig-University of Giessen, Bad Nauheim, Germany, ³Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁴Orthopedic & Trauma Surgery, Agaplesion Markus-Hospital, Frankfurt, Frankfurt, Germany, ⁵Dept Orthopedics and Experimental Orthopedics, University Hospital of Giessen and Marburg, Giessen, Germany, ⁶Dept of Orthopedics and Orthopedic Surgery, University Hospital of Giessen and Marburg, Gießen, Germany, ⁷Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Obesity is associated with an increased risk of osteoarthritis also in non-weight bearing joints and increased amounts of visceral fat are associated with lower…
Abstract Number: 2084 • 2015 ACR/ARHP Annual Meeting
Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Modulates Bone Resorption in Inflammatory Arthritis and Fracture Repair
Yahui Grace Chiu¹, Tzong-Ren Sheu², Jinbo Li³, Dongge Li⁴, Michael Thullen², Brendan Boyce⁵, Christopher T. Ritchlin⁶ and Javier Rangel-Moreno⁷, ¹Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, ²Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ³Pathology, University of Rochester, Rochester, NY, ⁴Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁵University of Rochester, Rochester, NY, ⁶Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY, ⁷Allergy, Immunology & Rheumatology, University of Rochester, Rochester, NY
Background/Purpose: Osteoclasts (OC) direct pathologic bone resorption in osteoporosis and inflammatory arthritis. We previously demonstrated that DC-STAMP (Dendritic Cell-Specific Transmembrane protein), a 7-pass transmembrane protein,…
Abstract Number: 2087 • 2015 ACR/ARHP Annual Meeting
Defective Circadian Control in Mesenchymal Cells Reduces Adult Bone Mass
Julia F. Charles¹ and Joerg Ermann², ¹Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Genetic disruption of the circadian molecular clock in mice is a powerful tool to dissect the role of circadian rhythms in health and disease.…
Abstract Number: 22 • 2014 ACR/ARHP Annual Meeting
Adenosine a_2A Receptor (A2AR) Stimulation Inhibits Osteoclast Differentiation and Promotes Osteoblast Formation By Regulation of Axon Guidance Proteins
Aranzazu Mediero¹, Miguel Perez-Aso² and Bruce N. Cronstein³, ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²545 1st Ave., New York University, New York City, NY, ³NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Semaphorins (Sema), axonal guidance proteins, play a role in communication between osteoclast and osteoblast. Thus, sema4D, secreted by osteoclasts, binds to its receptor PlexinB1…
Abstract Number: 1830 • 2013 ACR/ARHP Annual Meeting
Adenosine A_2A Receptor (A2AR) Diminishes Wear Particle (UHMWPE)-Mediated Osteolysis, Increases Bone Formation and Regulates Expression Of Axonal Guidance Proteins (AGP) By Macrophages, Osteoclasts (OC) and Osteoblasts (OB)
Aranzazu Mediero¹, Tuere Wilder², Miguel Perez-Aso³ and Bruce N. Cronstein⁴, ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Medicine, division of Translational Medicine, NYU School of Medicine, New York, NY, ³Department of Translational Medicine, New York University School of Medicine, New York, NY, ⁴Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Communication between OC and OB is critical for maintenance of bone homeostasis; both OC and OB release regulatory messengers. Among these signaling molecules are…
Abstract Number: 2516 • 2012 ACR/ARHP Annual Meeting
Adenosine Receptors Stimulate Bone Regeneration by Targeting Osteoclasts
Aranzazu Mediero¹, Tuere Wilder² and Bruce N. Cronstein³, ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Medicine, division of Translational Medicine, NYU School of Medicine, New York, NY, ³Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Various types of orthopedic procedures, including spinal fusion and repair of bone defects due to trauma, infection or metastatic disease, require formation of new…
Abstract Number: 16 • 2012 ACR/ARHP Annual Meeting
Adenosine A_2A Receptor Diminishes Bone Destruction At Inflamed Sites, in Part, Via Downregulating Semaphorin4D-PlexinB1 Communication Between Osteoclasts and Osteoblasts
Aranzazu Mediero¹ and Bruce N. Cronstein², ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Communication between osteoclasts and osteoblasts is essential for bone homeostasis. Semaphorin4D (Sema4D), expressed on the surface of and secreted by osteoclasts, macrophages and T…

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