Abstracts tagged "osteoblasts and osteoclastogenesis"

Abstract Number: 1098 • ACR/ARHP Annual Meeting 2016
ZCCHC6/TUT7 Negatively Regulates Osterix Activity and Influences Osteoblast-Mediated Regulation of Osteoclastogenesis
Gregory Sondag¹, Mohammad Khan¹, Mohammad Ansari², Nazar Hussein^1,3, Sara Haynie¹, Fayez Safadi¹ and Tariq M. Haqqi¹, ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ³School of Biomedical Sciences, Kent State University, Kent, OH
Background/Purpose: Mechanisms associated with intrinsic mRNA regulation are important players in development and disease processes. The terminal uridylyl transferases (TUT) are a family of enzymes…
Abstract Number: 1965 • ACR/ARHP Annual Meeting 2012
Adenosine Regulates Bone Metabolism Via A₁, A_2A and A_2B Receptors in Bone Marrow Cells From Normal and Patients with Multiple Myeloma
Wenjie He¹, Amitabha Mazumder² and Bruce N. Cronstein³, ¹Dept of Med, Div of Rheum, NYU, New York, NY, ²NYU Cancer Center, New York, NY, ³Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Multiple myeloma is a haematologic malignancy that is characterized by osteolytic bone lesions, wherein coupled bone remodeling is disrupted with increased osteoclast activation and…
Abstract Number: 45 • ACR/ARHP Annual Meeting 2012
The Effects of Apremilast On Osteoclasts, Osteoblasts, and Osteocytes
Mary Adams and Peter Schafer, Department of Translational Development, Celgene Corporation, Summit, NJ
Background/Purpose: Apremilast (APR), a small molecule specific inhibitor of phosphodiesterase 4, works intracellularly to modulate pro- and anti-inflammatory mediator production in both immune and non-immune…