ACR Meeting Abstracts

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Abstracts tagged "Osteoblasts"

  • Abstract Number: 1990 • 2019 ACR/ARP Annual Meeting

    Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor

    Aranzazu Mediero1, Patricia Llamas-Granda 2, Bruce Cronstein 3, Raquel Largo 4 and Gabriel Herrero-Beaumont 4, 1IIS-FUNDACION JIMENEZ DIAZ, Madrid, Spain, 2IIS-FUNDACION JIMENEX DIAZ, Madrid, Spain, 3Department of Medicine, Division of Rheumatology NYUSoM, NYC, 4IIS-Fundación Jiménez Díaz, Madrid, Madrid, Spain

    Background/Purpose: Semaphorins (Sema) are a family of proteins associated with neuronal development and guidance. Sema4D/CD100 was first identified as a regulator of immune response in…
  • Abstract Number: 2218 • 2019 ACR/ARP Annual Meeting

    1,25D3 Promotes Mineralization of Osteoblasts by Activating C/EBPβ-DKK1 Axis

    Sungsin Jo1, Subin Yoon 1, Seoung Wan Nam 2, Jae-Hyuk Yang 3, Il-hoon Sung 4 and Tae-Hwan Kim 1, 1Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, 2Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea, 3Department of Orthopedic Surgery, Hanyang University Medical Center, Guri Hospital,, Guri, Republic of Korea, 4Division of Orthopedics, Hanyang University Hospital for Rheumatic Diseases, Seoul, Seoul-t'ukpyolsi, Republic of Korea

    Background/Purpose: 1,25-Dihydroxyvitamin D3 (1,25D3) has a positive therapeutic effect on osteoporosis by activating osteoblasts. Bone formation is a dynamic and sequential process that comprises osteoblasts…
  • Abstract Number: 1025 • 2018 ACR/ARHP Annual Meeting

    MiR-146a a Key Player in Bone Metabolism

    Victoria Saferding1, Melanie Hofmann1, Julia S. Brunner2, Mihaela Militaru1, Antonia Puchner1, Silvia Hayer3, Gernot Schabbauer4, Melanie Timmen5, Richard Stange5, Josef S. Smolen6 and Stephan Blüml7, 1Medical University of Vienna, Austria, Vienna, Austria, 2Vascular Biology and Thrombosis research, Medical University of Vienna, Austria, Vienna, Austria, 3Waehringer Guertel 18-20 A-A09, Medical University of Vienna, Austria, Vienna, Austria, 4Vascular Biology and Thrombosis research, Medical University of Vienna, Vienna, Austria, 5Institute for Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, 6Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, 7Division of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria

    Background/Purpose: Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis…
  • Abstract Number: 1038 • 2018 ACR/ARHP Annual Meeting

    Tenofovir, a Nucleoside Analog Reverse Transcriptase Inhibitor for Treatment of HIV, Promotes Osteoclast Differentiation and Decreases Osteoblast Formation By a Mechanism Depending on ATP Release and Adenosine

    Francisco Miguel Conesa-Buendia1, Patricia Llamas2, Raquel Largo3, Gabriel Herrero-Beaumont3, Bruce N. Cronstein4 and Aranzazu Mediero5, 1Bone and Joint Research Unit, IIS-Fundacion Jimenez Diaz- UAM, Madrid, Spain, 2Bone and Joint Research Unit, IIS-Fundacion Jimenez Díaz-UAM, Madrid, Spain, 3Bone and Joint Research Unit, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, 4Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY, 5Joint and Bone Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain

    Background/Purpose: Human Immunodeficiency Virus (HIV) infection devastates the immune system but also affects tissues and organs such as kidney, liver, central nervous system, heart and…
  • Abstract Number: 63 • 2017 ACR/ARHP Annual Meeting

    MiR-146a a Key Player in Bone Metabolism

    Victoria Saferding1, Melanie Hofmann1, Julia S. Brunner2, Antonia Puchner1, Melanie Timmen3, Richard Stange3, Josef S. Smolen4 and Stephan Blüml4, 1Medical University of Vienna, Austria, Vienna, Austria, 2Vascular Biology and Thrombosis research, Medical University of Vienna, Austria, Vienna, Austria, 3Institute for Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, 4Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria

    Background/Purpose: Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis…
  • Abstract Number: 68 • 2017 ACR/ARHP Annual Meeting

    Tankyrase/Wnt Inhibitor Upregulates Osteoclastogenesis and Osteoblastogenesis Via SH3BP2

    Shunichi Fujita1, Tomoyuki Mukai1, Takafumi Mito1, Shoko Kodama1, Akiko Nagasu1, Mizuho Kittaka2, Yasuyoshi Ueki3 and Yoshitaka Morita1, 1Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, 2Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Missouri-Kansas City, MO, MO, 3Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Missouri-Kansas City, MO

    Background/Purpose: Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Since tankyrase inhibitors increase Axin protein, a negative regulator…
  • Abstract Number: 959 • 2017 ACR/ARHP Annual Meeting

    A Disintegrin and Metalloprotease -17 Is Overexpressed on Rheumatoid Arthritis Osteoblasts and Is Regulated with TNF-α Stimulation

    Hidekazu Furuya, Takeo Isozaki, Shinichiro Nishimi, Airi Nishimi, Takahiro Tokunaga, Kuninobu Wakabayashi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: A disintegrin and metalloprotease family proteins (ADAMs) have been reported to be involved in a number of inflammatory conditions. We have previously reported a…
  • Abstract Number: 1661 • 2016 ACR/ARHP Annual Meeting

    Toll-like Receptor 4 Induced IL-20 and IL-24 Stimulate Osteoblast Mineralization and Are Increased in Spondyloarthritis

    Tue Wenzel Kragstrup1,2, Morten Nørgaard Andersen3, Berit Schiøttz-Christensen4, Anne Grethe Jurik5, Malene Hvid6 and Bent Deleuran1, 1Department of Biomedicine, Aarhus University, Aarhus, Denmark, 2Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 3Aarhus University, Aarhus, Denmark, 4Hospital Lillebaelt, Middelfart, Denmark, 5Aarhus University Hospital, Aarhus, Denmark, 6Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

    Background/Purpose: The pathogenesis of spondyloarthritis (SpA) involves activation of the innate immune system, inflammation and new bone formation. The innate immune system is activated through…
  • Abstract Number: 1035 • 2015 ACR/ARHP Annual Meeting

    Synovium-Derived microRNAs Inhibit Bone Formation in Rheumatoid Arthritis

    Ellen M. Gravallese1, Yukiko Maeda2, Nicholas H Farina3, Paul Fanning4 and Jane Lian3, 1Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA, 2Medicine, University of Massachusetts Medical School, Worcester, MA, 3Department of Biochemistry, University of Vermont, Burlington, VT, 4Department of Orthopedics, University of Massachusetts Medical School, Worcester, MA

    Background/Purpose: Articular bone erosion in rheumatoid arthritis (RA) is a consequence of synovial inflammation that leads to disability for patients. Cells within the synovium secrete…
  • Abstract Number: 2205 • 2015 ACR/ARHP Annual Meeting

    Inhibition of Dickkopf1 Dampens Anti Osteogenic Effect of Fibroblast-like Synoviocytes

    Eiji Sugiyama, Yusuke Yoshida and Satoshi Yamasaki, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan

    Background/Purpose:   Fibroblast-Like Synoviocytes (FLS) play important roles in RA progression. Previous studies have revealed importance of FLS in osteoclast activation, however, the roles of…
  • Abstract Number: 2215 • 2015 ACR/ARHP Annual Meeting

    Ticagrelor Regulates Osteoblast and Osteoclast Function and Promotes Bone Formation in Vivo By Increasing Adenosine Levels 

    Aranzazu Mediero1, Tuere Wilder2, Carl Whatling3 and Bruce Cronstein4, 1Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, 2Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, 3CVMD Innovative Medicine Unit, Translational Sciences, AstraZeneca R&D, Mölndal, Sweden, 4Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY

    Background/Purpose: The antiplatelet drugs Ticagrelor and clopidogrel are P2Y12 antagonists but ticagrelor also inhibits cellular adenosine uptake via ENT1 and thereby increases extracellular adenosine levels.…
  • Abstract Number: 3170 • 2015 ACR/ARHP Annual Meeting

    Peripheral Osteoblastogenesis in Rheumatoid Arthritis Is Enhanced after TNF Blocker Treatment, Irrespective of Systemic Inflammation

    Mie Jin Lim1, Won Park2, Seong-Ryul Kwon2, Kyong-Hee Jung2 and Min Jung Son3, 1Division of Rheumatology, Department of Internal Medicine,, Inha University Hospital, Incheon, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea, 3Inha University Hospital, Incheon, South Korea

    Background/Purpose: We investigated osteoclastogenesis and osteoblastogenesis in peripheral blood before and 6 months after TNF blocker treatment in seropositive RA patients. Methods:            Seventeen seropositive…
  • Abstract Number: 19 • 2014 ACR/ARHP Annual Meeting

    Adenosine Receptors Stimulate Bone Regeneration

    Aranzazu Mediero1, Tuere Wilder2 and Bruce N. Cronstein3, 1Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, 2Medicine, division of Translational Medicine, NYU School of Medicine, New York, NY, 3NYU School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose Such orthopedic procedures as spinal fusion and repair of bone defects due to trauma, infection or metastatic disease, require formation of new bone. Adenosine,…
  • Abstract Number: 25 • 2014 ACR/ARHP Annual Meeting

    DC-STAMP Modulates Osteoblast Differentiation and Regulates Bone Repair

    Yahui Grace Chiu1, Tzong-Ren Sheu2, Jinbo Li3, Dongge Li1, Michael Thullen2, Brendan Boyce4, Edward Puzas2 and Christopher T. Ritchlin5, 1Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 2Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 3Pathology, University of Rochester, Rochester, NY, 4Pathology, University of Rochester, Rocehster, NY, 5Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY

    Background/Purpose Patients with osteoporosis and the elderly have an increased risk of bone fracture. Currently, no biomarker is available to assess bone healing status in…
  • Abstract Number: 2820 • 2014 ACR/ARHP Annual Meeting

    Dual Role for B Cells in Promoting Bone Erosion in Rheumatoid Arthritis Via Effects on Osteoclast and Osteoblast Differentiation

    Nida Meednu1, Hengwei Zhang2, Teresa Owen3, Lianping Xing4 and Jennifer H. Anolik5, 1Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 2Pathology and Laboratory Medicine, University of Rochester, Rochester, NY, 3Rheumatology, University of Rochester, Rochester, NY, 4Pathology & Lab Medicine, University of Rochester, Rochester, NY, 5Medicine- Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY

    Background/Purpose Rheumatoid arthritis (RA) is a systemic autoimmune disease that often leads to joint damage, a process mediated by an imbalance between bone resorption and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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