Abstracts tagged "Osteoblasts"

Abstract Number: 1990 • 2019 ACR/ARP Annual Meeting
Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor
Aranzazu Mediero¹, Patricia Llamas-Granda ², Bruce Cronstein ³, Raquel Largo ⁴ and Gabriel Herrero-Beaumont ⁴, ¹IIS-FUNDACION JIMENEZ DIAZ, Madrid, Spain, ²IIS-FUNDACION JIMENEX DIAZ, Madrid, Spain, ³Department of Medicine, Division of Rheumatology NYUSoM, NYC, ⁴IIS-Fundación Jiménez Díaz, Madrid, Madrid, Spain
Background/Purpose: Semaphorins (Sema) are a family of proteins associated with neuronal development and guidance. Sema4D/CD100 was first identified as a regulator of immune response in…
Abstract Number: 2218 • 2019 ACR/ARP Annual Meeting
1,25D3 Promotes Mineralization of Osteoblasts by Activating C/EBPβ-DKK1 Axis
Sungsin Jo¹, Subin Yoon ¹, Seoung Wan Nam ², Jae-Hyuk Yang ³, Il-hoon Sung ⁴ and Tae-Hwan Kim ¹, ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ²Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea, ³Department of Orthopedic Surgery, Hanyang University Medical Center, Guri Hospital,, Guri, Republic of Korea, ⁴Division of Orthopedics, Hanyang University Hospital for Rheumatic Diseases, Seoul, Seoul-t'ukpyolsi, Republic of Korea
Background/Purpose: 1,25-Dihydroxyvitamin D3 (1,25D3) has a positive therapeutic effect on osteoporosis by activating osteoblasts. Bone formation is a dynamic and sequential process that comprises osteoblasts…
Abstract Number: 1025 • 2018 ACR/ARHP Annual Meeting
MiR-146a a Key Player in Bone Metabolism
Victoria Saferding¹, Melanie Hofmann¹, Julia S. Brunner², Mihaela Militaru¹, Antonia Puchner¹, Silvia Hayer³, Gernot Schabbauer⁴, Melanie Timmen⁵, Richard Stange⁵, Josef S. Smolen⁶ and Stephan Blüml⁷, ¹Medical University of Vienna, Austria, Vienna, Austria, ²Vascular Biology and Thrombosis research, Medical University of Vienna, Austria, Vienna, Austria, ³Waehringer Guertel 18-20 A-A09, Medical University of Vienna, Austria, Vienna, Austria, ⁴Vascular Biology and Thrombosis research, Medical University of Vienna, Vienna, Austria, ⁵Institute for Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁶Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, ⁷Division of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria
Background/Purpose: Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis…
Abstract Number: 1038 • 2018 ACR/ARHP Annual Meeting
Tenofovir, a Nucleoside Analog Reverse Transcriptase Inhibitor for Treatment of HIV, Promotes Osteoclast Differentiation and Decreases Osteoblast Formation By a Mechanism Depending on ATP Release and Adenosine
Francisco Miguel Conesa-Buendia¹, Patricia Llamas², Raquel Largo³, Gabriel Herrero-Beaumont³, Bruce N. Cronstein⁴ and Aranzazu Mediero⁵, ¹Bone and Joint Research Unit, IIS-Fundacion Jimenez Diaz- UAM, Madrid, Spain, ²Bone and Joint Research Unit, IIS-Fundacion Jimenez Díaz-UAM, Madrid, Spain, ³Bone and Joint Research Unit, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, ⁴Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY, ⁵Joint and Bone Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain
Background/Purpose: Human Immunodeficiency Virus (HIV) infection devastates the immune system but also affects tissues and organs such as kidney, liver, central nervous system, heart and…
Abstract Number: 68 • 2017 ACR/ARHP Annual Meeting
Tankyrase/Wnt Inhibitor Upregulates Osteoclastogenesis and Osteoblastogenesis Via SH3BP2
Shunichi Fujita¹, Tomoyuki Mukai¹, Takafumi Mito¹, Shoko Kodama¹, Akiko Nagasu¹, Mizuho Kittaka², Yasuyoshi Ueki³ and Yoshitaka Morita¹, ¹Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, ²Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Missouri-Kansas City, MO, MO, ³Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Missouri-Kansas City, MO
Background/Purpose: Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Since tankyrase inhibitors increase Axin protein, a negative regulator…
Abstract Number: 959 • 2017 ACR/ARHP Annual Meeting
A Disintegrin and Metalloprotease -17 Is Overexpressed on Rheumatoid Arthritis Osteoblasts and Is Regulated with TNF-α Stimulation
Hidekazu Furuya, Takeo Isozaki, Shinichiro Nishimi, Airi Nishimi, Takahiro Tokunaga, Kuninobu Wakabayashi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan
Background/Purpose: A disintegrin and metalloprotease family proteins (ADAMs) have been reported to be involved in a number of inflammatory conditions. We have previously reported a…
Abstract Number: 63 • 2017 ACR/ARHP Annual Meeting
MiR-146a a Key Player in Bone Metabolism
Victoria Saferding¹, Melanie Hofmann¹, Julia S. Brunner², Antonia Puchner¹, Melanie Timmen³, Richard Stange³, Josef S. Smolen⁴ and Stephan Blüml⁴, ¹Medical University of Vienna, Austria, Vienna, Austria, ²Vascular Biology and Thrombosis research, Medical University of Vienna, Austria, Vienna, Austria, ³Institute for Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁴Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria
Background/Purpose: Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis…
Abstract Number: 1661 • 2016 ACR/ARHP Annual Meeting
Toll-like Receptor 4 Induced IL-20 and IL-24 Stimulate Osteoblast Mineralization and Are Increased in Spondyloarthritis
Tue Wenzel Kragstrup^1,2, Morten Nørgaard Andersen³, Berit Schiøttz-Christensen⁴, Anne Grethe Jurik⁵, Malene Hvid⁶ and Bent Deleuran¹, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Aarhus University, Aarhus, Denmark, ⁴Hospital Lillebaelt, Middelfart, Denmark, ⁵Aarhus University Hospital, Aarhus, Denmark, ⁶Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Background/Purpose: The pathogenesis of spondyloarthritis (SpA) involves activation of the innate immune system, inflammation and new bone formation. The innate immune system is activated through…
Abstract Number: 1035 • 2015 ACR/ARHP Annual Meeting
Synovium-Derived microRNAs Inhibit Bone Formation in Rheumatoid Arthritis
Ellen M. Gravallese¹, Yukiko Maeda², Nicholas H Farina³, Paul Fanning⁴ and Jane Lian³, ¹Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA, ²Medicine, University of Massachusetts Medical School, Worcester, MA, ³Department of Biochemistry, University of Vermont, Burlington, VT, ⁴Department of Orthopedics, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Articular bone erosion in rheumatoid arthritis (RA) is a consequence of synovial inflammation that leads to disability for patients. Cells within the synovium secrete…
Abstract Number: 2205 • 2015 ACR/ARHP Annual Meeting
Inhibition of Dickkopf1 Dampens Anti Osteogenic Effect of Fibroblast-like Synoviocytes
Eiji Sugiyama, Yusuke Yoshida and Satoshi Yamasaki, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: Fibroblast-Like Synoviocytes (FLS) play important roles in RA progression. Previous studies have revealed importance of FLS in osteoclast activation, however, the roles of…
Abstract Number: 2215 • 2015 ACR/ARHP Annual Meeting
Ticagrelor Regulates Osteoblast and Osteoclast Function and Promotes Bone Formation in Vivo By Increasing Adenosine Levels
Aranzazu Mediero¹, Tuere Wilder², Carl Whatling³ and Bruce Cronstein⁴, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, ³CVMD Innovative Medicine Unit, Translational Sciences, AstraZeneca R&D, Mölndal, Sweden, ⁴Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY
Background/Purpose: The antiplatelet drugs Ticagrelor and clopidogrel are P2Y12 antagonists but ticagrelor also inhibits cellular adenosine uptake via ENT1 and thereby increases extracellular adenosine levels.…
Abstract Number: 3170 • 2015 ACR/ARHP Annual Meeting
Peripheral Osteoblastogenesis in Rheumatoid Arthritis Is Enhanced after TNF Blocker Treatment, Irrespective of Systemic Inflammation
Mie Jin Lim¹, Won Park², Seong-Ryul Kwon², Kyong-Hee Jung² and Min Jung Son³, ¹Division of Rheumatology, Department of Internal Medicine,, Inha University Hospital, Incheon, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea, ³Inha University Hospital, Incheon, South Korea
Background/Purpose: We investigated osteoclastogenesis and osteoblastogenesis in peripheral blood before and 6 months after TNF blocker treatment in seropositive RA patients. Methods: Seventeen seropositive…
Abstract Number: 2820 • 2014 ACR/ARHP Annual Meeting
Dual Role for B Cells in Promoting Bone Erosion in Rheumatoid Arthritis Via Effects on Osteoclast and Osteoblast Differentiation
Nida Meednu¹, Hengwei Zhang², Teresa Owen³, Lianping Xing⁴ and Jennifer H. Anolik⁵, ¹Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ²Pathology and Laboratory Medicine, University of Rochester, Rochester, NY, ³Rheumatology, University of Rochester, Rochester, NY, ⁴Pathology & Lab Medicine, University of Rochester, Rochester, NY, ⁵Medicine- Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY
Background/Purpose Rheumatoid arthritis (RA) is a systemic autoimmune disease that often leads to joint damage, a process mediated by an imbalance between bone resorption and…
Abstract Number: 1001 • 2014 ACR/ARHP Annual Meeting
Fibroblast-like Synoviocytes Inhibit Wnt Signaling Pathway By Secreting Dockcop-1
Satoshi Yamasaki and Eiji Sugiyama, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: There is evidence of osteoclast activation in the inflamed joints of patients with rheumatoid arthritis (RA). Studies that focus on osteoblasts are not sufficient…
Abstract Number: 609 • 2014 ACR/ARHP Annual Meeting
Induced Pluripotent Stem Cells (iPSCs) As a Tool for Unraveling the Role of Different Cell Types in the Disease Process of Spondyloarthritis Pathogenesis
Gerlinde Layh-Schmitt¹, Shjia Lu², Fatemeh Navid², Massimo Gadina² and Robert A. Colbert², ¹10 Center Drive., NIAMS/NIH, Bethesda, MD, ²NIAMS/NIH, Bethesda, MD
Background/Purpose: Many genetic factors and cell types contribute to the axial inflammation, trabecular bone loss, and aberrant bone formation that result in ankylosing spondylitis. The…

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