Abstracts tagged "osteoblast"

Abstract Number: 0027 • ACR Convergence 2024
Cation Channel TRPC1 Regulates Mesenchymal Stem Cell Differentiation and Bone Formation
Jyoti Yadav¹, Shivmurat Yadav², Jeremy Houser¹, Marta Onopuik³, Leonidas Tsiokas³ and Mary Beth Humphrey¹, ¹University of Oklahoma College of Medicine, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³University of Oklahoma College of Medicine, Oklahoma City
Background/Purpose: Transient receptor potential canonical 1 (TRPC1), a non-selective cation channel, is characterized by its high permeability to calcium ions (Ca2+), a vital second messenger…
Abstract Number: 0936 • ACR Convergence 2024
Schnurri-3 Inhibition Protects from NF-kB-induced Bone Loss in Inflammatory Arthritis
Priyanka Kushwaha¹, Catherine Manning², Tadatoshi Sato³, Yeon-Suk Yang³, Jae-Hyuck Shim⁴ and Ellen Gravallese⁵, ¹Department of Medicine/Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Boston, MA, ²Brigham and Women's Hospital, Dedham, MA, ³Department of Medicine/Division of Rheumatology, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, ⁴University of Massachusetts, Worcester, MA, ⁵Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA
Background/Purpose: In rheumatoid arthritis (RA), production of TNF promotes osteoclast activity and inhibits osteoblasts (OBs) and bone healing. Schnurri-3 (SHN3) is a potent suppressor of…
Abstract Number: 1710 • ACR Convergence 2024
Extl3 Involved in the Regulation of Endochondral Ossification in Axial SpA
Stéphane Hilliquin¹, OLIVIER FOGEL², Mathilde Tissier³, Chahrazad Cherifi⁴, Karim Ibrahim⁵, Judith Melki⁶, Robert Olaso⁷, Brigitte Baroukh⁵, Philippe Dieudé⁸, Lars Rogge³, Elisabetta Bianchi³, Marcio Do Cruzeiro⁹, Frederique Cornelis¹⁰, Rik Lories¹⁰, Patricia Albanese⁴, Xavier Houard¹¹, Claire Bardet⁵ and Corinne MICELI¹², ¹Département de Rhumatologie, Hôpital Cochin, Assistance publique des Hôpitaux de Paris, Université Paris-Cité, Paris, France, PARIS, France, ²AP-HP, Paris, France, ³Institut Pasteur, Université Paris Cité, Immunoregulation Unit, F-75015 Paris, France, PARIS, France, ⁴Laboratoire Gly-CREET, Université Paris-Est Créteil Val de Marne (UPEC) Faculté des sciences et technologies, Créteil, France, ⁵Université Paris Cité, Institut des maladies musculo-squelettiques, Laboratory Orofacial Pathologies, Imaging and Biotherapies URP2496 and FHU-DDS-Net, Dental School, and Plateforme d’Imagerie du Vivant (PIV), Montrouge, France,, Montrouge, France, ⁶Université Paris-Saclay, Laboratory Diseases and Hormones of the Nervous Systems, Inserm U1195, Le Kremlin Bicêtre, France, Le Kremlin Bicêtre, France, ⁷Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, Evry, Evry, France, ⁸Departement of Rheumatology, AP-HP, Bichat Hospital, Paris, France, ⁹Plateformes PDA et MouseT'IC, Institut Cochin, Université Paris Cité, Paris, France, PARIS, France, ¹⁰Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, Leuven, Belgium, ¹¹Centre de Recherche Saint-Antoine, UMR_S938 INSERM /Sorbonne Université, Paris, France, Paris, France, ¹²Université de Paris Cité, APHP, Paris, France
Background/Purpose: Spondyloarthritis (SpA) is an inflammatory rheumatic disease characterized, in its axial form, by lesions affecting the spine and/or sacroiliac joints (SIJ). Severe forms of…
Abstract Number: 2567 • ACR Convergence 2024
Gene Expression in Osteonecrosis of the Femoral Head: A Region-matched RNA-sequencing Study
Lucy Eunju Lee¹, Seung Hwan Lee², Miri Kim², Jieun Kim², Joo Sung Shim², Eun Gyel Shin², Tae Sung Lee², Hyuck Min Kwon², Young Han Lee², Hun-Mu Yang², Kwan Kyu Park² and Jason Jungsik Song², ¹Yonsei University, Seoul, South Korea, ²Yonsei University College of Medicine, Seoul, Republic of Korea
Background/Purpose: Osteonecrosis of the femoral head (ONFH) is linked to diverse risk factors like glucocorticoid use and excessive alcohol consumption. Various cells may influence bone…
Abstract Number: 1788 • ACR Convergence 2023
The Emerging Mechanism of TNF&IL-17A/WNT5a/ROR2 Axis in Pathological Bone Formation of Ankylosing Spondylitis
Sungsin Jo¹, Seung Hoon Lee¹, Chanhyeok Jeon¹, Sung Hoon Choi², Ye-Soo Park³ and Tae-Hwan Kim⁴, ¹Hanyang University Institute for Rheumatology Research, Seoul, South Korea, ²Hanyang University Seoul Hospital, Seoul, South Korea, ³Hanyang University College of Medicine, Guri, South Korea, ⁴Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: Enthesitis is one of the most distinctive features and signs of ectopic bone formation in ankylosing spondylitis (AS). The Wnt/β-catenin pathway and Th17 cells…
Abstract Number: 2014 • ACR Convergence 2023
The Role of Orosomucoid 2 in the Regulation of Bone Remodeling by Inhibiting Osteoclastogenesis and Promoting Osteogenesis
CHONG HYUK CHUNG¹, Myeung-Su Lee¹ and Chang-hoon Lee², ¹Wonkwang University Hospital, Iksan, South Korea, ²Wonkwang University Hospital, Iksan Jeonbuk, South Korea
Background/Purpose: Orosomucoid (ORM) is one of the acute phase reactant protein family and is expressed in hepatocytes and secreted into plasma under stress conditions such…
Abstract Number: 0073 • ACR Convergence 2023
PD-1hi Cells Are Highly Present in the Rheumatoid Joint, and Express Regulatory Capacities
Sofie Rask¹, Christian Andersen², Malene Hvid¹, Kim Ravnskjær², Bent Deleuran¹ and Stinne Greisen³, ¹Aarhus University, Aarhus, Denmark, ²University of Southern Denmark, Odense, Denmark, ³Aarhus University/Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: Programmed death 1 (PD-1) is an immune checkpoint receptor expressed by activated T cells, and of major importance in maintaining peripheral tolerance. Expression of…
Abstract Number: 0846 • ACR Convergence 2023
Preosteoclast Plays a Pathogenic Role in Syndesmophyte Formation of Ankylosing Spondylitis Through the Secreted PDGFB – GRB2/ERK/RUNX2 Pathway
Yulong Tang¹, Qingmei Liu¹, Kunhai Tang¹, Chengchun Geng¹, Jiangnan Xie¹, Jiucun Wang², Qi Zhu³ and Jing Liu¹, ¹Fudan University, Shanghai, China, ²Shanghai, Shanghai, China, ³Guanghua Integrative Medicine Hospital, Shanghai, China
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease that mainly affects the sacroiliac joint and spine. However, the real mechanisms of immune cells acting…
Abstract Number: 1304 • ACR Convergence 2022
Glucocorticoids Affect Bone Mass and Strength by Inhibiting Osteoprogenitor Cell Maturation
Thomas Ambrosi¹, Mathew Murphy¹, Charles KF Chan¹ and Nancy Lane², ¹Stanford University, Stanford, CA, ²University of California Davis, Hillsborough, CA
Background/Purpose: Glucocorticoid (GC) induced osteoporosis remains a significant health issue. While GCs are known to reduce bone formation and bone mass, patients treated with GCs…
Abstract Number: 0447 • ACR Convergence 2021
Bone Anabolic Effects of a Novel Orally-Available Small Molecule SIK2/SIK3 Inhibitor
Cheng-Chia Tang¹, Shiv Verma¹, Steve De Vos², David Amantini³, Philippe Clement-Lacroix³, Nicolas Desroy³, Antonio Speziale⁴, Daniel Brooks⁵, Mary Bouxsein⁵, Janaina da Silva Martins¹, Yingshe Zhao⁶, Henry Kronenberg¹ and Marc Wein¹, ¹MGH Endocrine Unit, Boston, MA, ²Galapagos NV, Mechelen, Belgium, ³Galapagos SASU, Romainville, France, ⁴Galapagos GmbH, Basel, Switzerland, ⁵Beth Israel Deaconess Medical Center, Boston, MA, ⁶MGH Endocrine Unnit, Boston, MA
Background/Purpose: Orally-available bone anabolic agents represent a major unmet medical need for patients with osteoporosis. Widespread use of parathyroid hormone (PTH)-based osteo-anabolic therapies is limited…
Abstract Number: 0117 • ACR Convergence 2020
Development of an In Vitro Trabecular Human Bone Model to Recapitulate Features of Glucocorticoid-induced Osteoporosis
Annemarie Lang¹, Karoline Diesing¹, Alexandra Damerau¹, Moritz Pfeiffenberger¹, Timo Gaber¹ and Frank Buttgereit², ¹Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, ²Charité University Medicine, Berlin, Germany
Background/Purpose: The bone matrix consists of inorganic and organic components and a variety of specialized cells such as osteoblasts, osteocytes and osteoclasts. The bone-forming osteoblasts…
Abstract Number: 0966 • ACR Convergence 2020
Decoupling Inflammation and Bone Loss in Rheumatoid Arthritis via Schnurri-3
Zheni Stavre¹, JungMin Kim², Jae-Hyuck Shim² and Ellen Gravallese³, ¹University of Massachusetts Medical School-Rheumatology Division, Worcester, MA, ²University of Massachusetts Medical School, Worcester, MA, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to local and systemic bone loss. TNF is a key mediator of bone loss,…
Abstract Number: 1528 • ACR Convergence 2020
Filgotinib Inhibits Monocyte Differentiation and Pro Inflammatoly Cytokine Production in Osteoblasts
Takeo Isozaki¹, Yuzo Ikari¹ and Tsuyoshi Kasama², ¹Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan, ²Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Koutou-ku Tokyo, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction. Filgotinib is a selective small molecule inhibitor of JAK 1…
Abstract Number: 1943 • 2019 ACR/ARP Annual Meeting
The Emerging Regulatory Function of microRNA146a in Bone Biology and Osteoporosis
Victoria Saferding¹, Melanie Hofmann ², Julia S. Brunner ², Mihaela F. Militaru ², Antonia Puchner ², Silvia Hayer ², Melanie Timmen ³, Richard Stange ³, Josef Smolen ² and Stephan Blüml ⁴, ¹Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ²Medical University of Vienna, Vienna, Austria, ³University Hospital Muenster, Muenster, Germany, ⁴Medical University of Vienna, Vienna
Background/Purpose: Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis…

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